Personality measures after gamma ventral capsulotomy in intractable OCD

Carregando...
Imagem de Miniatura
Citações na Scopus
9
Tipo de produção
article
Data de publicação
2018
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Indexadores
Título da Revista
ISSN da Revista
Título do Volume
Métricas da Revista
Autores
MCLAUGHLIN, Nicole C.
CANTERAS, Miguel M.
GREENBERG, Benjamin D.
NOREN, Georg
RASMUSSEN, Steven A.
Autor de Grupo de pesquisa
Editores
Coordenadores
Organizadores
Citação
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, v.81, p.161-168, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: Neurosurgeries such as gamma ventral capsulotomy (GVC) are an option for otherwise intractable obsessive-compulsive disorder (OCD) patients. In general, clinical and neuropsychological status both improve after GVC. However, its consequences on personality traits are not well-studied. The objective of this study was to investigate personality changes after one year of GVC in intractable OCD patients. Methods: The personality assessment was conducted using the Revised NEO Personality Inventory (NEO PI-R) and Cloninger's Temperament and Character Inventory (TCI) in 14 intractable OCD patients before and one year after GVC. Comparisons of personality features between treatment responders (n = 5) and non-responders (n = 9) were performed. Multiple linear regression was also used for predicting changes in clinical and global functioning variables. Results: Overall, no deleterious effect was found in personality after GVC. Responders had a reduction in neuroticism (p = 0.043) and an increase in extraversion (p = 0.043). No significant changes were observed in nonresponders. Increases in novelty seeking and self-directedness, and decreases in persistence and cooperativiness predicted OCD symptom improvement. Similary, improvement in functioning was also predicted by hgher novelty seeking and self-directedness after GVC, whereas better functioning was also associated with lower reward dependence and cooperativeness after surgery. Conclusions: The pattern of changes in personality traits after GVC was generally towards that observed in nonclinical population, and does not raise safety concerns.
Palavras-chave
Gamma ventral capsulotomy, Personality, Neuroticism, Extraversion, Radiosurgery, Obsessive-compulsive disorder
Referências
  1. American Psychiatric Association, 1994, DIAGN STAT MAN MENT
  2. American Psychiatric Association, 2013, AM J PSYCHIAT
  3. Andrade LH, 2012, PLOS ONE, V7, DOI 10.1371/journal.pone.0031879
  4. Batistuzzo MC, 2015, NEUROPSYCHOPHARMACOL, V40, P1837, DOI 10.1038/npp.2015.33
  5. BECK AT, 1988, J CONSULT CLIN PSYCH, V56, P893, DOI 10.1037//0022-006X.56.6.893
  6. BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
  7. Belotto-Silva C, 2012, J ANXIETY DISORD, V26, P25, DOI 10.1016/j.janxdis.2011.08.008
  8. Bloch MH, 2006, MOL PSYCHIATR, V11, P622, DOI 10.1038/sj.mp.4001823
  9. Castle D, 2015, AUSTRALAS PSYCHIATRY, V23, P350, DOI 10.1177/1039856215590027
  10. Cloninger CR, 2012, J AFFECT DISORDERS, V136, P758, DOI 10.1016/j.jad.2011.09.046
  11. CLONINGER CR, 1993, ARCH GEN PSYCHIAT, V50, P975
  12. Corchs F, 2008, REV BRAS PSIQUIATR, V30, P246, DOI 10.1590/S1516-44462008000300012
  13. COSTA PT, 1988, J PERS SOC PSYCHOL, V54, P853, DOI 10.1037//0022-3514.54.5.853
  14. Costa P.T., 1992, ODESSA FL PSYCHOL AS, V3, P101
  15. Deckersbach T, 2006, DEPRESS ANXIETY, V23, P133, DOI 10.1002/da.20152
  16. Gabriels L, 2003, ACTA PSYCHIAT SCAND, V107, P275, DOI 10.1034/j.1600-0447.2003.00066.x
  17. GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
  18. Greenberg BD, 2003, NEUROSURG CLIN N AM, V14, P199, DOI 10.1016/S1042-3680(03)00005-6
  19. Greenberg B. D., 2017, KAPLAN SADOCKS COMPR, P3299
  20. Guy W., 1976, ECDEU ASSESSMENT MAN, V76, P218
  21. HAY P, 1993, ACTA PSYCHIAT SCAND, V87, P197, DOI 10.1111/j.1600-0447.1993.tb03356.x
  22. Hirschtritt ME, 2017, JAMA-J AM MED ASSOC, V317, P1358, DOI 10.1001/jama.2017.2200
  23. Hoexter MQ, 2012, NEUROPSYCHOPHARMACOL, V37, P734, DOI 10.1038/npp.2011.250
  24. Husted DS, 2004, CNS SPECTRUMS, V9, P833
  25. Kampman O., 2017, CURR PSYCHIAT REP
  26. Kapogiannis D, 2013, HUM BRAIN MAPP, V34, P2829, DOI 10.1002/hbm.22108
  27. Kempe PT, 2007, ACTA PSYCHIAT SCAND, V116, P201, DOI 10.1111/j.1600-0447.2007.00997.x
  28. Kondziolka D, 2011, NEUROSURGERY, V68, P28, DOI 10.1227/NEU.0b013e3181fc5c8b
  29. Lopes AC, 2014, JAMA PSYCHIAT, V71, P1066, DOI 10.1001/jamapsychiatry.2014.1193
  30. Lopes AC, 2009, J NEUROPSYCH CLIN N, V21, P381, DOI 10.1176/appi.neuropsych.21.4.381
  31. Lyoo IK, 2003, ACTA PSYCHIAT SCAND, V107, P298, DOI 10.1034/j.1600-0447.2003.00054.x
  32. McKay D, 2015, PSYCHIAT RES, V227, P104, DOI 10.1016/j.psychres.2015.02.004
  33. MINDUS P, 1991, ACTA PSYCHIAT SCAND, V83, P283, DOI 10.1111/j.1600-0447.1991.tb05541.x
  34. Mindus P, 1999, ACTA PSYCHIAT SCAND, V99, P40, DOI 10.1111/j.1600-0447.1999.tb05383.x
  35. Pallanti S, 2006, PROG NEURO-PSYCHOPH, V30, P400, DOI 10.1016/j.pnpbp.2005.11.028
  36. Ruck C, 2008, ARCH GEN PSYCHIAT, V65, P914, DOI 10.1001/archpsyc.65.8.914
  37. Ruscio AM, 2010, MOL PSYCHIATR, V15, P53, DOI 10.1038/mp.2008.94
  38. Rylander G., 2017, FRONTAL LOBES, P691
  39. SACHDEV P, 1995, J NERV MENT DIS, V183, P408, DOI 10.1097/00005053-199506000-00010
  40. Sugiura M, 2000, NEUROIMAGE, V11, P541, DOI 10.1006/nimg.2000.0564
  41. Taub A, 2009, J NEUROPSYCH CLIN N, V21, P393, DOI 10.1176/appi.neuropsych.21.4.393
  42. Tierney TS, 2014, INT J NEUROSCI, V124, P394, DOI 10.3109/00207454.2013.852086
  43. Tiwari R., 2014, INT J SCH CONG PSYCH, V1, P106
  44. Youn T, 2002, BIOL PSYCHOL, V60, P109, DOI 10.1016/S0301-0511(02)00047-9