Association between psoriasis and coronary calcium score

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSTANIAK, Henrique L.
dc.contributor.authorBITTENCOURT, Marcio Sommer
dc.contributor.authorSANTOS, Itamar de Souza
dc.contributor.authorSHAROVSKY, Rodolfo
dc.contributor.authorSABBAG, Cid
dc.contributor.authorGOULART, Alessandra C.
dc.contributor.authorLOTUFO, Paulo A.
dc.contributor.authorBENSENOR, Isabela M.
dc.date.accessioned2015-04-22T22:06:26Z
dc.date.available2015-04-22T22:06:26Z
dc.date.issued2014
dc.description.abstractBackground: Emerging data suggests that chronic inflammatory disease, such as psoriasis, may be associated to coronary artery disease (CAD). Objective: Analyze the association between psoriasis and subclinical atherosclerosis using coronary calcium score (CAC). Methods: We investigated 221 participants with psoriasis and 718 age-and sex-matched controls without prior known CAD. All participants completed a questionnaire and underwent laboratory tests and a CAC exam. Logistic regression models adjusted for Framingham risk score (FRS) and C-reactive protein (hs-CRP) were built. CAC was included in the models as a binary variable with different cut off values. Results: Body-mass index, race, hypertension, HDL, LDL and hs-CRP were significantly associated with psoriasis presence and severity. Psoriasis severity was significantly associated with CAC (p = 0.04), particularly for very high CAC (>400) (p <0.01). The OR for severe psoriasis and CAC >400 was 2.45 (95%CI: 1.26-4.75) in unadjusted models. In a model adjusted for the FRS, this association was no longer significant, but a trend was noted (p = 0.09). No significant changes in the association were noted after the inclusion of hs-CRP in the model. Conclusion: Psoriasis is associated with higher CAC values, mainly in individuals with severe psoriasis. The current findings also suggest the potential involvement of other mechanisms beyond classical cardiovascular risk factors and inflammation in this association.
dc.description.indexMEDLINE
dc.description.sponsorshipCNPq
dc.description.sponsorshipFundacao para Amparo a Pesquisa do Estado de Sao Paulo, Sao Paulo, Brazil [2011/7601-4, 2011/12256-4]
dc.description.sponsorshipBrazilian Ministry of Health (Science and Technology Department), Brasilia, Brazil [FINEP: 06 0115.00 SP]
dc.identifier.citationATHEROSCLEROSIS, v.237, n.2, p.847-852, 2014
dc.identifier.doi10.1016/j.atherosclerosis.2014.11.004
dc.identifier.eissn1879-1484
dc.identifier.issn0021-9150
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8916
dc.language.isoeng
dc.publisherELSEVIER IRELAND LTD
dc.relation.ispartofAtherosclerosis
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER IRELAND LTD
dc.subjectCoronary artery calcium
dc.subjectCardiovascular disease
dc.subjectCardiovascular risk factors
dc.subjectPsoriasis
dc.subjectSubclinical atherosclerosis
dc.subject.othersubclinical atherosclerosis
dc.subject.otherartery-disease
dc.subject.otherrisk-factors
dc.subject.otherarthritis
dc.subject.otherprevalence
dc.subject.otherhealth
dc.subject.wosPeripheral Vascular Disease
dc.titleAssociation between psoriasis and coronary calcium score
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSHAROVSKY, Rodolfo:Univ Sao Paulo, Univ Hosp, Div Internal Med, BR-05508 Sao Paulo, Brazil; Univ Sao Paulo, Univ Hosp, Ctr Clin & Epidemiol Res, BR-05508 Sao Paulo, Brazil
hcfmusp.citation.scopus39
hcfmusp.contributor.author-fmusphcHENRIQUE LANE STANIAK
hcfmusp.contributor.author-fmusphcMARCIO SOMMER BITTENCOURT
hcfmusp.contributor.author-fmusphcITAMAR DE SOUZA SANTOS
hcfmusp.contributor.author-fmusphcCID YAZIGI SABBAG
hcfmusp.contributor.author-fmusphcALESSANDRA CARVALHO GOULART
hcfmusp.contributor.author-fmusphcPAULO ANDRADE LOTUFO
hcfmusp.contributor.author-fmusphcISABELA JUDITH MARTINS BENSEñOR
hcfmusp.description.beginpage847
hcfmusp.description.endpage852
hcfmusp.description.issue2
hcfmusp.description.volume237
hcfmusp.origemWOS
hcfmusp.origem.pubmed25463132
hcfmusp.origem.scopus2-s2.0-84911123142
hcfmusp.origem.wosWOS:000346066600101
hcfmusp.publisher.cityCLARE
hcfmusp.publisher.countryIRELAND
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