Deleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorOLIVEIRA, Walmar Roncalli de
dc.contributor.authorSILVA, Lana Luiza da Cruz
dc.contributor.authorFESTA NETO, Cyro
dc.contributor.authorTYRING, Stephen
dc.date.accessioned2015-10-26T16:26:49Z
dc.date.available2015-10-26T16:26:49Z
dc.date.issued2015
dc.description.abstractBackground: Epidermodysplasia verruciformis (EV) is a rare genodermatosis caused by specific human papillomavirus (HPV) types associated with the development of multiple squamous cell carcinomas (SCC). The treatment for this skin tumour may be difficult. Among the therapy options, radiotherapy (RT) should be avoided due to its deleterious effects on HPV-induced carcinogenesis. Objective: To describe 4 patients with EV who underwent radiotherapy to treat cutaneous SCC. Methods: This is a retrospective study. The evolution of cutaneous SCC after adjuvant radiotherapy in 4 patients with EV was observed. Results: This study included 4 patients with diagnosis of EV. All 4 of the patients had cutaneous SCC. They underwent surgical resection and adjuvant radiotherapy. Over a period of up to 2 years, there was aggressive tumour recurrence. Conclusion: Radiotherapy might be associated with progression of SCC in patients with EV, and it is recommended that radiotherapy should be avoided in this patient population.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF CUTANEOUS MEDICINE AND SURGERY, v.19, n.4, p.416-421, 2015
dc.identifier.doi10.1177/1203475415576859
dc.identifier.eissn1615-7109
dc.identifier.issn1203-4754
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11633
dc.language.isoeng
dc.publisherSAGE PUBLICATIONS INC
dc.relation.ispartofJournal of Cutaneous Medicine and Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright SAGE PUBLICATIONS INC
dc.subjectepidermodysplasia verruciformis
dc.subjectskin cancer
dc.subjectradiotherapy
dc.subject.otherof-the-literature
dc.subject.othercancer
dc.subject.othermodel
dc.subject.otherskin
dc.subject.wosDermatology
dc.titleDeleterious Effect of Radiation Therapy on Epidermodysplasia Verruciformis Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalTYRING, Stephen:Univ Texas Hlth Sci Ctr Houston, Houston, TX 77030 USA
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcWALMAR RONCALLI PEREIRA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcLANA LUIZA DA CRUZ SILVA
hcfmusp.contributor.author-fmusphcCYRO FESTA NETO
hcfmusp.description.beginpage416
hcfmusp.description.endpage421
hcfmusp.description.issue4
hcfmusp.description.volume19
hcfmusp.origemWOS
hcfmusp.origem.pubmed26156649
hcfmusp.origem.scopus2-s2.0-84949643307
hcfmusp.origem.wosWOS:000357736700017
hcfmusp.publisher.cityTHOUSAND OAKS
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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