Recombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardiovirus

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOSTA, Antonio Charlys da
dc.contributor.authorLUCHS, Adriana
dc.contributor.authorMILAGRES, Flavio Augusto de Padua
dc.contributor.authorKOMNINAKIS, Shirley Vasconcelos
dc.contributor.authorGILL, Danielle Elise
dc.contributor.authorLOBATO, Marcia Cristina Alves Brito Sayao
dc.contributor.authorBRUSTULIN, Rafael
dc.contributor.authorCHAGAS, Rogerio Togisaki das
dc.contributor.authorABRAO, Maria de Fatima Neves dos Santos
dc.contributor.authorSOARES, Cassia Vitoria de Deus Alves
dc.contributor.authorDENG, Xutao
dc.contributor.authorSABINO, Ester Cerdeira
dc.contributor.authorDELWART, Eric
dc.contributor.authorLEAL, Elcio
dc.date.accessioned2019-01-17T13:33:14Z
dc.date.available2019-01-17T13:33:14Z
dc.date.issued2018
dc.description.abstractHere we report the nearly full-length genome of a recombinant Saffold virus strain (SAFV-BR-193) isolated from a child with acute gastroenteritis. Evolutionary analysis performed using all available near-full length Saffold picornavirus genomes showed that the breakpoint found in the Brazilian strain (SAFV-BR-193) is indeed a recombination hotspot. Notably, this hotspot is located just one nucleotide after the ribosomal frameshift GGUUUUU motif in the SAFV genome. Empirical studies will be necessary to determine if this motif also affects the binding affinity of RNA-dependent RNA-polymerase (RdRp) and therefore increases the changes of RdRp swap between molecules during the synthesis of viral genomes.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFAPESP [2015/12944-9, 2016/01735-2, 2017/00021-9]
dc.description.sponsorshipCNPq [400354/2016-0]
dc.identifier.citationVIRUSES-BASEL, v.10, n.10, article ID 520, 12p, 2018
dc.identifier.doi10.3390/v10100520
dc.identifier.issn1999-4915
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29949
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofViruses-Basel
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectsaffold viruseng
dc.subjectcardioviruseng
dc.subjectviromeeng
dc.subjectpicornaviruseng
dc.subjectribosomal frameshiftingeng
dc.subjectGGUUUUU motifeng
dc.subjectRNA-dependent RNA-polymeraseeng
dc.subject.otherinfectionseng
dc.subject.otherchildreneng
dc.subject.otherviruseseng
dc.subject.wosVirologyeng
dc.titleRecombination Located over 2A-2B Junction Ribosome Frameshifting Region of Saffold Cardioviruseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalLUCHS, Adriana:Adolfo Lutz Inst, Virol Ctr, Enter Dis Lab, BR-01246000 Sao Paulo, Brazil
hcfmusp.author.externalKOMNINAKIS, Shirley Vasconcelos:ABC, Fac Med, Postgrad Program Hlth Sci, BR-09060870 Santo Andre, Brazil; Univ Fed Sao Paulo, Retrovirol Lab, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalLOBATO, Marcia Cristina Alves Brito Sayao:Secretary Hlth Tocantins, BR-77453000 Tocantins, Brazil; Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalBRUSTULIN, Rafael:Secretary Hlth Tocantins, BR-77453000 Tocantins, Brazil; Fed Univ Tocantins, Inst Biol Sci, BR-77001090 Tocantins, Brazil; Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalCHAGAS, Rogerio Togisaki das:Secretary Hlth Tocantins, BR-77453000 Tocantins, Brazil; Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalABRAO, Maria de Fatima Neves dos Santos:Secretary Hlth Tocantins, BR-77453000 Tocantins, Brazil; Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalSOARES, Cassia Vitoria de Deus Alves:Secretary Hlth Tocantins, BR-77453000 Tocantins, Brazil; Publ Hlth Lab Tocantins State LACEN TO, BR-77016330 Tocantins, Brazil
hcfmusp.author.externalDENG, Xutao:Blood Syst Res Inst, San Francisco, CA 94143 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.author.externalDELWART, Eric:Blood Syst Res Inst, San Francisco, CA 94143 USA; Univ Calif San Francisco, Dept Lab Med, San Francisco, CA 94143 USA
hcfmusp.author.externalLEAL, Elcio:Fed Univ Para, Inst Biol Sci, BR-66075000 Belem, Para, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcANTONIO CHARLYS DA COSTA
hcfmusp.contributor.author-fmusphcFLAVIO AUGUSTO DE PADUA MILAGRES
hcfmusp.contributor.author-fmusphcDANIELLE ELISE GILL
hcfmusp.contributor.author-fmusphcESTER CERDEIRA SABINO
hcfmusp.description.articlenumber520
hcfmusp.description.issue10
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.pubmed30249971
hcfmusp.origem.scopus2-s2.0-85054152952
hcfmusp.origem.wosWOS:000448821200008
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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