25-Hydroxyvitamin D and TSH as Risk Factors or Prognostic Markers in Thyroid Carcinoma
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Citações na Scopus
24
Tipo de produção
article
Data de publicação
2016
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Editora
PUBLIC LIBRARY SCIENCE
Citação
PLOS ONE, v.11, n.10, article ID e0164550, 12p, 2016
Resumo
Objective The increasing incidence of thyroid nodules demands identification of risk factors for malignant disease. Several studies suggested the association of higher TSH levels with cancer, but influence of 25-hydroxyvitamin D (25OHD) is controversial. This study aimed to identify the relationship of thyroid cancer with higher TSH levels and hypovitaminosis D and to evaluate their influence on prognostic characteristics of papillary thyroid carcinomas (PTC). Methods We retrospectively evaluated 433 patients submitted to thyroidectomy for thyroid nodules. Patients were categorized according to quartiles of TSH and 25OHD levels. Clinicopathological features were analyzed. Results Subjects with thyroid carcinomas were more frequently male and younger compared to those with benign disease. Their median TSH levels were higher and adjusted odds-ratio (OR) for cancer in the highest-quartile of TSH (> 2.4 mUI/mL) was 2.36 (1.36-4.09). Although vitamin D deficiency/insufficiency was prevalent in our cohort (84%), no significant differences in 25OHD levels or quartile distribution were observed between benign and malignant cases. Among 187 patients with PTC, analyses of prognostic features revealed increased risk of lymph nodes metastases for subjects with highest-quartile TSH levels (OR = 3.7, p = 0.029). Decreased 25OHD levels were not overtly associated with poor prognosis in PTC. Conclusions In this cross-sectional cohort, higher TSH levels increased the risk of cancer in thyroid nodules and influenced its prognosis, particularly favoring lymph nodes metastases. On theother hand, no association was found between 25OHD levels and thyroid carcinoma risk or prognosis, suggesting that serum 25OHD determination may not contribute to risk assessment workup of thyroid nodules.
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Referências
- ABE E, 1981, P NATL ACAD SCI-BIOL, V78, P4990, DOI 10.1073/pnas.78.8.4990
- Ahn HY, 2016, THYROID, V26, P429, DOI 10.1089/thy.2015.0516
- Akslen LA, 1998, BRIT J CANCER, V77, P1174, DOI 10.1038/bjc.1998.195
- Bade B, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0112863
- Bauer SR, 2013, MEDICINE, V92, P123, DOI 10.1097/MD.0b013e3182943bc2
- Ben-Shoshan M, 2007, MOL CANCER THER, V6, P1433, DOI 10.1158/1535-7163.MCT-06-0677
- Bises G, 2004, J HISTOCHEM CYTOCHEM, V52, P985, DOI 10.1369/jhc.4B6271.2004
- Blutt SE, 2000, ENDOCRINOLOGY, V141, P10, DOI 10.1210/en.141.1.10
- Chailurkit LO, 2013, THYROID, V23, P25, DOI 10.1089/thy.2012.0001
- Chen W, 2007, BRIT J CANCER, V97, P123, DOI 10.1038/sj.bjc.6603834
- Chlebowski RT, 2008, J NATL CANCER I, V100, P1581, DOI 10.1093/jnci/djn360
- Chung KW, 2006, CLIN ENDOCRINOL, V65, P660, DOI 10.1111/j.1365-2265.2006.02646.x
- Cipriani C, 2014, INT J ENDOCRINOL, V2014, DOI [10.1155/2014/841248, DOI 10.1155/2014/841248]
- EISMAN JA, 1979, LANCET, V2, P1335
- Feldman D, 2014, NAT REV CANCER, V14, P342, DOI 10.1038/nrc3691
- Fiore E, 2009, ENDOCR-RELAT CANCER, V16, P1251, DOI 10.1677/ERC-09-0036
- Fraser A, 2010, PLOS ONE, V5, DOI 10.1371/journal.pone.0013882
- GARLAND CF, 1989, LANCET, V2, P1176
- Gilbert R, 2011, CANCER CAUSE CONTROL, V22, P319, DOI 10.1007/s10552-010-9706-3
- Gissel T, 2008, J STEROID BIOCHEM, V111, P195, DOI 10.1016/j.jsbmb.2008.06.002
- Greene FL, 2002, AJCC CANC STAGING MA
- Haugen B. R., 2015, THYROID, DOI [10.1089/thy.2015.0020, DOI 10.1089/THY.2015.0020]
- Haymart MR, 2009, CLIN ENDOCRINOL, V71, P434, DOI 10.1111/j.1365-2265.2008.03489.x
- HOELTING T, 1993, BIOCHEM BIOPH RES CO, V195, P1230, DOI 10.1006/bbrc.1993.2176
- Holick MF, 2008, AM J CLIN NUTR, V87, p1080S
- Holick MF, 2011, J CLIN ENDOCR METAB, V96, P1911, DOI 10.1210/jc.2011-0385
- Hsieh TC, 1996, BIOCHEM BIOPH RES CO, V223, P141, DOI 10.1006/bbrc.1996.0859
- Hughes DT, 2011, THYROID, V21, P231, DOI 10.1089/thy.2010.0137
- Izkhakov E, 2016, J STEROID BIOCHEM, V159, P26, DOI 10.1016/j.jsbmb.2016.02.016
- Jonklaas J, 2013, THYROID, V23, P1079, DOI 10.1089/thy.2012.0548
- Jonklaas J, 2006, THYROID, V16, P1229, DOI 10.1089/thy.2006.16.1229
- Kim JR, 2014, THYROID, V24, P1618, DOI 10.1089/thy.2014.0090
- Kim SS, 2011, ENDOCRINE, V39, P259, DOI 10.1007/s12020-010-9430-5
- Kmiec P, 2015, EXP CLIN ENDOCR DIAB, V123, P386, DOI 10.1055/s-0035-1554714
- Krishnan AV, 2010, ENDOCRINOLOGY, V151, P32, DOI 10.1210/en.2009-0855
- Laney N, 2010, INT J ENDOCRINOL, V2010, DOI [10.1155/2010/805716, DOI 10.1155/2010/805716]
- Lee HJ, 2014, CANCER-AM CANCER SOC, V120, P521, DOI 10.1002/cncr.28368
- Lee JE, 2011, CANCER PREV RES, V4, P735, DOI 10.1158/1940-6207.CAPR-10-0289
- Leyssens C, 2013, ENDOCR-RELAT CANCER, V20, pR31, DOI 10.1530/ERC-12-0381
- Li MA, 2014, J CLIN ENDOCR METAB, V99, P2327, DOI 10.1210/jc.2013-4320
- McLeod DSA, 2012, J CLIN ENDOCR METAB, V97, P2682, DOI 10.1210/jc.2012-1083
- Mithal A, 2009, OSTEOPOROSIS INT, V20, P1807, DOI 10.1007/s00198-009-0954-6
- Morand Gregoire B, 2014, Front Oncol, V4, P309, DOI 10.3389/fonc.2014.00309
- Moreno J, 2005, CANCER RES, V65, P7917, DOI 10.1158/0008-5472.CAN-05-1435
- Muenstedt K, 2010, BREAST CARE, V5, P383, DOI 10.1159/000322651
- O'Grady TJ, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110886
- Palmer HG, 2001, J CELL BIOL, V154, P369, DOI 10.1083/jcb.200102028
- Peppone LJ, 2012, ANN SURG ONCOL, V19, P2590, DOI 10.1245/s10434-012-2297-3
- Pereira F, 2012, ENDOCR-RELAT CANCER, V19, pR51, DOI 10.1530/ERC-11-0388
- Ray R, 2012, ANTICANCER RES, V32, P727
- Roskies M, 2012, J OTOLARYNGOL-HEAD N, V41, P160, DOI 10.2310/7070.2011.110174
- Ross AC, 2011, J CLIN ENDOCR METAB, V96, P53, DOI 10.1210/jc.2010-2704
- Sahin M, 2013, MED ONCOL, V30, DOI 10.1007/s12032-013-0589-5
- Shin DY, 2014, ENDOCR-RELAT CANCER, V21, P715, DOI 10.1530/ERC-14-0259
- SKOWRONSKI RJ, 1993, ENDOCRINOLOGY, V132, P1952, DOI 10.1210/en.132.5.1952
- Stepien T, 2010, ARCH MED RES, V41, P190, DOI 10.1016/j.arcmed.2010.04.004
- Swami S, 2016, ENDOCR-RELAT CANCER, DOI [10.1530/ERC-15-0557, DOI 10.1530/ERC-15-0557]
- Tuohimaa P, 2004, INT J CANCER, V108, P104, DOI 10.1002/ijc.11375
- Unger MD, 2010, CLIN NUTR, V29, P784, DOI 10.1016/j.clnu.2010.06.009
- Vimaleswaran KS, 2013, PLOS MED, V10, DOI 10.1371/journal.pmed.1001383
- Wang LL, 2004, J STEROID BIOCHEM, V89-90, P127, DOI 10.1016/j.jsbmb.2004.03.091
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Artigos e Materiais de Revistas Científicas - FM/MCG
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Artigos e Materiais de Revistas Científicas - HC/ICHC
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Artigos e Materiais de Revistas Científicas - LIM/25
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Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/18
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Artigos e Materiais de Revistas Científicas - LIM/28