ASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTY

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLEITE, Chilan Bou Ghosson
dc.contributor.authorRANZONI, Lucas Verissimo
dc.contributor.authorGIGLIO, Pedro Nogueira
dc.contributor.authorBONADIO, Marcelo Batista
dc.contributor.authorMELO, Lucas Da Ponte
dc.contributor.authorDEMANGE, Marco Kawamura
dc.contributor.authorGOBBI, Riccardo Gomes
dc.date.accessioned2020-06-01T14:54:52Z
dc.date.available2020-06-01T14:54:52Z
dc.date.issued2020
dc.description.abstractObjective: To evaluate the profile of blood loss and blood transfusions after the introduction of Tranexamic acid (TXA) in a tertiary university hospital in Brazil. Methods: 173 patients were retrospectively divided into two groups: the ones who received TXA and the control group. Hemoglobin levels (Hb), drain output, transfusion rates, and thromboembolic events were measured. Results: Among the patients included in this study, 82 cases received TXA. Blood transfusion occurred in 3 cases of the TXA group (3.7%), and in 27 control group cases (29.7%; p < 0.001). The average Hb decrease was 2.7 g/dl (+/- 1.39) and the median drain output was 270 mL in the TXA group. In the control group, the values were 3.41 g/dl (+/- 1.34; p < 0.001) and 460 mL (p < 0.001), respectively. Thromboembolic events occurred in 2 TXA group cases (2.4%) and in 3 control group cases (3.3%; p > 0.999). Conclusion: TXA was effective in reducing blood transfusion rates, Hb decrease, and drain output on the 1st postoperative day without increasing thromboembolic events.eng
dc.description.indexPubMedeng
dc.identifier.citationACTA ORTOPEDICA BRASILEIRA, v.28, n.2, p.74-77, 2020
dc.identifier.doi10.1590/1413-785220202802228410
dc.identifier.eissn1809-4406
dc.identifier.issn1413-7852
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/36024
dc.language.isoeng
dc.publisherATHA COMUNICACAO & EDITORAeng
dc.relation.ispartofActa Ortopedica Brasileira
dc.rightsopenAccesseng
dc.rights.holderCopyright ATHA COMUNICACAO & EDITORAeng
dc.subjectTranexamic Acideng
dc.subjectBlood Transfusioneng
dc.subjectKnee Replacement Arthroplastyeng
dc.subject.otherblood-losseng
dc.subject.otherprophylaxiseng
dc.subject.otherstrategieseng
dc.subject.othersafeeng
dc.subject.otherhipeng
dc.subject.wosOrthopedicseng
dc.titleASSESSMENT OF THE USE OF TRANEXAMIC ACID AFTER TOTAL KNEE ARTHROPLASTYeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.citation.scopus6
hcfmusp.contributor.author-fmusphcCHILAN BOU GHOSSON LEITE
hcfmusp.contributor.author-fmusphcLUCAS VERISSIMO RANZONI
hcfmusp.contributor.author-fmusphcPEDRO NOGUEIRA GIGLIO
hcfmusp.contributor.author-fmusphcMARCELO BATISTA BONADIO
hcfmusp.contributor.author-fmusphcLUCAS DA PONTE MELO
hcfmusp.contributor.author-fmusphcMARCO KAWAMURA DEMANGE
hcfmusp.contributor.author-fmusphcRICCARDO GOMES GOBBI
hcfmusp.description.beginpage74
hcfmusp.description.endpage77
hcfmusp.description.issue2
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed32425668
hcfmusp.origem.scieloSCIELO:S1413-78522020000200074
hcfmusp.origem.scopus2-s2.0-85083792771
hcfmusp.origem.wosWOS:000528274000005
hcfmusp.publisher.citySAO PAULO SPeng
hcfmusp.publisher.countryBRAZILeng
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