Evaluation of an IFN-gamma Assay in the Diagnosis of Latent Tuberculosis in Patients with Psoriasis in a Highly Endemic Setting

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorLIMA, Emerson de Andrade
dc.contributor.authorLIMA, Mariana de Andrade
dc.contributor.authorLORENA, Virginia M. Barros de
dc.contributor.authorGOMES, Yara de Miranda
dc.contributor.authorLUPI, Omar
dc.contributor.authorBENARD, Gil
dc.date.accessioned2017-11-27T16:26:17Z
dc.date.available2017-11-27T16:26:17Z
dc.date.issued2011
dc.description.abstractScreening for latent tuberculosis infection is mandatory before starting anti-tumour necrosis factor treatments, but its diagnosis still poses a challenge. While studies performed in developed countries have demonstrated superior performance of T-cell based interferon-gamma release assay (IGRA) compared with the tuberculin skin test, there is a debate about whether this holds true in tuberculosis endemic areas. The performance of an IGRA kit (T-SPOT.TB) was evaluated in 33 moderate-to-severe untreated psoriasis patients and, as controls, 30 patients with common dermatological diseases at a tuberculosis highly endemic setting. The frequency of positive tuberculin skin test responses and induration size in controls were higher than in psoriasis patients (53% vs. 18% and 9.3 +/- 1.4 vs. 2.6 +/- 0.7 mm, respectively, p<0.001). In contrast, the frequency of positive response and mean number of spots elicited with the T-SPOT.TB test were not significantly different between patients and controls (47% vs. 43% and 14.7 +/- 3.2 vs. 20.5 +/- 3.1 spots/well, respectively). The two tests presented good agreement in the control, but not the psoriasis group (kappa values of 0.625 and 0.375, respectively). Thus, in a highly tuberculosis-endemic setting the T-SPOT.TB test was superior to the tuberculin skin test in diagnosing latent tuberculosis infection in psoriasis, probably because the immune dysregulation of psoriasis shows a lower interference in the in vitro test.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa de Sao Paulo [2008/57608-2]
dc.identifier.citationACTA DERMATO-VENEREOLOGICA, v.91, n.6, p.694-697, 2011
dc.identifier.doi10.2340/00015555-1151
dc.identifier.issn0001-5555
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/22940
dc.language.isoeng
dc.publisherACTA DERMATO-VENEREOLOGICA
dc.relation.ispartofActa Dermato-Venereologica
dc.rightsopenAccess
dc.rights.holderCopyright ACTA DERMATO-VENEREOLOGICA
dc.subjectpsoriasis
dc.subjectTNF
dc.subjecttuberculin skin test
dc.subjectlatent tuberculosis infection
dc.subjectinterferon-gamma release assay
dc.subjectELISPOT
dc.subject.otherskin-test
dc.subject.othermycobacterium-tuberculosis
dc.subject.otherrheumatoid-arthritis
dc.subject.otherblood-tests
dc.subject.otherinfection
dc.subject.otherinterferon
dc.subject.othertherapy
dc.subject.otherpopulation
dc.subject.otherexposure
dc.subject.othergambia
dc.subject.wosDermatology
dc.titleEvaluation of an IFN-gamma Assay in the Diagnosis of Latent Tuberculosis in Patients with Psoriasis in a Highly Endemic Setting
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalLIMA, Emerson de Andrade:Fed Univ State Pernambuco, Clin Hosp, Psoriasis Outpatient Serv, Recife, PE, Brazil
hcfmusp.author.externalLIMA, Mariana de Andrade:Fed Univ State Pernambuco, Clin Hosp, Psoriasis Outpatient Serv, Recife, PE, Brazil
hcfmusp.author.externalLORENA, Virginia M. Barros de:Osvaldo Cruz Fdn, Aggeu Magalhaes Res Inst, Recife, PE, Brazil
hcfmusp.author.externalGOMES, Yara de Miranda:Osvaldo Cruz Fdn, Aggeu Magalhaes Res Inst, Recife, PE, Brazil
hcfmusp.author.externalLUPI, Omar:Fed Univ State Rio Janeiro, Dept Dermatol, Rio De Janeiro, Brazil
hcfmusp.citation.scopus8
hcfmusp.contributor.author-fmusphcGIL BENARD
hcfmusp.description.beginpage694
hcfmusp.description.endpage697
hcfmusp.description.issue6
hcfmusp.description.volume91
hcfmusp.origemWOS
hcfmusp.origem.pubmed21629971
hcfmusp.origem.scopus2-s2.0-80055022400
hcfmusp.origem.wosWOS:000297889100010
hcfmusp.publisher.cityUPPSALA
hcfmusp.publisher.countrySWEDEN
hcfmusp.relation.referenceALORAINEY IO, 2009, ANN THORAC MED, V1, P5
hcfmusp.relation.referenceHill PC, 2004, CLIN INFECT DIS, V38, P966, DOI 10.1086/382362
hcfmusp.relation.referenceKang YA, 2005, JAMA-J AM MED ASSOC, V293, P2756, DOI 10.1001/jama.293.22.2756
hcfmusp.relation.referencePai M, 2005, JAMA-J AM MED ASSOC, V293, P2746, DOI 10.1001/jama.293.22.2746
hcfmusp.relation.referencede Leon DP, 2008, J RHEUMATOL, V35, P776
hcfmusp.relation.referenceEwer K, 2003, LANCET, V361, P1168, DOI 10.1016/S0140-6736(03)12950-9
hcfmusp.relation.referenceFerrara G, 2006, LANCET, V367, P1328, DOI 10.1016/S0140-6736(06)68579-6
hcfmusp.relation.referenceLalvani A, 2003, THORAX, V58, P916, DOI 10.1136/thorax.58.11.916
hcfmusp.relation.referenceLin J, 2008, CLIN IMMUNOL, V126, P13, DOI 10.1016/j.clim.2007.08.012
hcfmusp.relation.referenceTsiouri G, 2009, DERMATOLOGY, V219, P119, DOI 10.1159/000222431
hcfmusp.relation.referenceAndersen P, 2000, LANCET, V356, P1099, DOI 10.1016/S0140-6736(00)02742-2
hcfmusp.relation.referenceMarques CDL, 2009, RHEUMATOL INT, V30, P57, DOI 10.1007/s00296-009-0910-y
hcfmusp.relation.referenceLaffitte E, 2009, BRIT J DERMATOL, V161, P797, DOI 10.1111/j.1365-2133.2009.09331.x
hcfmusp.relation.referenceMahomed H, 2006, INT J TUBERC LUNG D, V10, P310
hcfmusp.relation.referencePai M, 2006, INT J TUBERC LUNG D, V10, P942
hcfmusp.relation.referencede Leon DP, 2005, ANN RHEUM DIS, V64, P1360, DOI 10.1136/ard.2004.029041
hcfmusp.relation.referenceDogan B, 1997, INT J DERMATOL, V36, P263, DOI 10.1046/j.1365-4362.1997.00164.x
hcfmusp.relation.referenceHill PC, 2006, PLOS ONE, V1, DOI 10.1371/journal.pone.0000068
hcfmusp.relation.referenceHill PC, 2008, PLOS ONE, V3, DOI 10.1371/journal.pone.0001379
hcfmusp.relation.referenceKAPP A, 1988, J INVEST DERMATOL, V90, P511, DOI 10.1111/1523-1747.ep12461005
hcfmusp.relation.referenceKRUEGER GG, 1978, J INVEST DERMATOL, V71, P189, DOI 10.1111/1523-1747.ep12547129
hcfmusp.relation.referenceLINDHOLM L, 1978, ARCH DERMATOL RES, V263, P121, DOI 10.1007/BF00446432
hcfmusp.relation.referenceMow WS, 2004, CLIN GASTROENTEROL H, V2, P309, DOI 10.1053/S1542-3565(04)00060-6
hcfmusp.relation.referenceMURAKAMI S, 2009, TUBERCULOSIS, V89, P139
hcfmusp.relation.referenceSellam J, 2007, ANN RHEUM DIS, V66, P1610, DOI 10.1136/ard.2007.069799
hcfmusp.relation.referenceSichletidis L, 2006, INT J TUBERC LUNG D, V10, P1127
hcfmusp.relation.referenceSilva LCR, 2010, ARCH DERMATOL RES, V302, P255, DOI 10.1007/s00403-009-0982-2
hcfmusp.relation.referenceSociedade Brasileira de Pneumologia e Tisiologia, 2009, J BRAS PNEUMOL, V35, P1018
hcfmusp.relation.referenceSOUZA TNL, 1999, THESIS MED SCH U SAO
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