Effects of early exercise on cardiac function and lipid metabolism pathway in heart failure

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUZA, Sergio Luiz Borges de
dc.contributor.authorMOTA, Gustavo Augusto Ferreira
dc.contributor.authorSILVA, Vitor Loureiro da
dc.contributor.authorVILEIGAS, Danielle Fernandes
dc.contributor.authorSANT'ANA, Paula Grippa
dc.contributor.authorGREGOLIN, Cristina Schmitt
dc.contributor.authorFIGUEIRA, Rebeca Lopes
dc.contributor.authorBATAH, Sabrina Setembre
dc.contributor.authorFABRO, Alexandre Todorovic
dc.contributor.authorMURATA, Gilson Masahiro
dc.contributor.authorBAZAN, Silmeia Garcia Zanati
dc.contributor.authorOKOSHI, Marina Politi
dc.contributor.authorCICOGNA, Antonio Carlos
dc.date.accessioned2024-02-15T14:39:38Z
dc.date.available2024-02-15T14:39:38Z
dc.date.issued2023
dc.description.abstractWe employed an early training exercise program, immediately after recovery from surgery, and before severe cardiac hypertrophy, to study the underlying mechanism involved with the amelioration of cardiac dysfunction in aortic stenosis (AS) rats. As ET induces angiogenesis and oxygen support, we aimed to verify the effect of exercise on myocardial lipid metabolism disturbance. Wistar rats were divided into Sham, trained Sham (ShamT), AS and trained AS (AST). The exercise consisted of 5-week sessions of treadmill running for 16 weeks. Statistical analysis was conducted by anova or Kruskal-Wallis test and Goodman test. A global correlation between variables was also performed using a two-tailed Pearson's correlation test. AST rats displayed a higher functional capacity and a lower cardiac remodelling and dysfunction when compared to AS, as well as the myocardial capillary rarefaction was prevented. Regarding metabolic properties, immunoblotting and enzymatic assay raised beneficial effects of exercise on fatty acid transport and oxidation pathways. The correlation assessment indicated a positive correlation between variables of angiogenesis and FA utilisation, as well as between metabolism and echocardiographic parameters. In conclusion, early exercise improves exercise tolerance and attenuates cardiac structural and functional remodelling. In parallel, exercise attenuated myocardial capillary and lipid metabolism derangement in rats with aortic stenosis-induced heart failure.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico [305399/2015-2, 310284/2019-8, 421058/2018-8, 442822/2014-6]
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo [2015/16934/8]
dc.description.sponsorshipPROPe
dc.description.sponsorshipPro-Reitoria de Pesquisa, Unesp
dc.description.sponsorshipUniversidade Estadual Paulista
dc.identifier.citationJOURNAL OF CELLULAR AND MOLECULAR MEDICINE, v.27, n.19, p.2956-2969, 2023
dc.identifier.doi10.1111/jcmm.17908
dc.identifier.eissn1582-4934
dc.identifier.issn1582-1838
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57871
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Cellular and Molecular Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectangiogenesiseng
dc.subjectaortic stenosiseng
dc.subjectfatty acid oxidationeng
dc.subjectphysical exerciseeng
dc.subjectpressure overloadeng
dc.subjectSIRT1eng
dc.subject.otherfailing hearteng
dc.subject.othercontractile dysfunctioneng
dc.subject.otherreceptor-alphaeng
dc.subject.otherhypertrophyeng
dc.subject.otherangiogenesiseng
dc.subject.otherexpressioneng
dc.subject.othercontributeseng
dc.subject.otherdisruptioneng
dc.subject.othertransitioneng
dc.subject.otherregulatoreng
dc.subject.wosCell Biologyeng
dc.subject.wosMedicine, Research & Experimentaleng
dc.titleEffects of early exercise on cardiac function and lipid metabolism pathway in heart failureeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSOUZA, Sergio Luiz Borges de:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalMOTA, Gustavo Augusto Ferreira:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalSILVA, Vitor Loureiro da:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalVILEIGAS, Danielle Fernandes:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalSANT'ANA, Paula Grippa:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalGREGOLIN, Cristina Schmitt:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalFIGUEIRA, Rebeca Lopes:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalBATAH, Sabrina Setembre:Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Legal Med, Sao Paulo, Brazil
hcfmusp.author.externalFABRO, Alexandre Todorovic:Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol & Legal Med, Sao Paulo, Brazil
hcfmusp.author.externalBAZAN, Silmeia Garcia Zanati:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalOKOSHI, Marina Politi:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil
hcfmusp.author.externalCICOGNA, Antonio Carlos:Sao Paulo State Univ, Botucatu Med Sch, Dept Internal Med, Botucatu, Brazil; Sao Paulo State Univ, Unesp, Dept Internal Med, Av Prof Mario Rubens Guimaraes Montenegro,S N, BR-18618687 Botucatu, SP, Brazil
hcfmusp.citation.scopus1
hcfmusp.contributor.author-fmusphcGILSON MASAHIRO MURATA
hcfmusp.description.beginpage2956
hcfmusp.description.endpage2969
hcfmusp.description.issue19
hcfmusp.description.volume27
hcfmusp.origemWOS
hcfmusp.origem.pubmed37654004
hcfmusp.origem.scopus2-s2.0-85169307451
hcfmusp.origem.wosWOS:001062480000001
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceArany Z, 2006, P NATL ACAD SCI USA, V103, P10086, DOI 10.1073/pnas.0603615103eng
hcfmusp.relation.referenceAubert G, 2016, CIRCULATION, V133, P698, DOI 10.1161/CIRCULATIONAHA.115.017355eng
hcfmusp.relation.referenceBarger PM, 1999, AM J MED SCI, V318, P36, DOI 10.1097/00000441-199907000-00006eng
hcfmusp.relation.referenceBatista DF., 2020, OXID MED CELL LONGEV, V2020, P1eng
hcfmusp.relation.referenceBedi KC, 2016, CIRCULATION, V133, P706, DOI 10.1161/CIRCULATIONAHA.115.017545eng
hcfmusp.relation.referenceBenjamin, 2020, CIRCULATION, V141, pE33, DOI 10.1161/CIR.0000000000000746eng
hcfmusp.relation.referenceBernardo BC, 2016, CARDIOL CLIN, V34, P515, DOI 10.1016/j.ccl.2016.06.002eng
hcfmusp.relation.referenceBIEBER LL, 1972, ANAL BIOCHEM, V50, P509, DOI 10.1016/0003-2697(72)90061-9eng
hcfmusp.relation.referencede Souza SLB, 2021, J CARDIOVASC TRANSL, V14, P674, DOI 10.1007/s12265-020-09997-0eng
hcfmusp.relation.referenceBregagnollo EA, 2007, INT J CARDIOL, V117, P109, DOI 10.1016/j.ijcard.2006.06.006eng
hcfmusp.relation.referenceBrown MD, 2003, EXP PHYSIOL, V88, P645, DOI 10.1113/eph8802618eng
hcfmusp.relation.referenceBugger H, 2010, CARDIOVASC RES, V85, P376, DOI 10.1093/cvr/cvp344eng
hcfmusp.relation.referenceVieira WHD, 2018, LASER MED SCI, V33, P803, DOI 10.1007/s10103-017-2424-2eng
hcfmusp.relation.referencede Souza Sergio Luiz Borges, 2020, Cell Physiol Biochem, V54, P665, DOI 10.33594/000000247eng
hcfmusp.relation.referenceDe Tomasi LC, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0193553eng
hcfmusp.relation.referenceDobrzyn P, 2013, AM J PHYSIOL-ENDOC M, V304, pE1348, DOI 10.1152/ajpendo.00603.2012eng
hcfmusp.relation.referenceDoenst T, 2013, CIRC RES, V113, P709, DOI 10.1161/CIRCRESAHA.113.300376eng
hcfmusp.relation.referenceDoenst T, 2010, CARDIOVASC RES, V86, P461, DOI 10.1093/cvr/cvp414eng
hcfmusp.relation.referenceDuncan JG, 2008, PPAR RES, V2008, DOI 10.1155/2008/253817eng
hcfmusp.relation.referenceGogiraju R, 2015, J AM HEART ASSOC, V4, DOI 10.1161/JAHA.115.001770eng
hcfmusp.relation.referenceGómez-Marcos MA, 2016, OXID MED CELL LONGEV, V2016, DOI 10.1155/2016/9124676eng
hcfmusp.relation.referenceHein S, 2003, CIRCULATION, V107, P984, DOI 10.1161/01.CIR.0000051865.66123.B7eng
hcfmusp.relation.referenceHolloway TM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0121138eng
hcfmusp.relation.referenceHsia CCW, 2010, AM J RESP CRIT CARE, V181, P394, DOI 10.1164/rccm.200809-1522STeng
hcfmusp.relation.referenceIngwall JS, 2006, CURR HYPERTENS REP, V8, P457, DOI 10.1007/s11906-006-0023-xeng
hcfmusp.relation.referenceIzumiya Y, 2006, HYPERTENSION, V47, P887, DOI 10.1161/01.HYP.0000215207.54689.31eng
hcfmusp.relation.referenceKolwicz SC, 2018, FRONT CARDIOVASC MED, V5, DOI 10.3389/fcvm.2018.00066eng
hcfmusp.relation.referenceLachance D, 2014, BMC CARDIOVASC DISOR, V14, DOI 10.1186/1471-2261-14-190eng
hcfmusp.relation.referenceLaPier TLK, 2001, PHYS THER, V81, P1006, DOI 10.1093/ptj/81.4.1006eng
hcfmusp.relation.referenceMiyachi M, 2009, HYPERTENSION, V53, P701, DOI 10.1161/HYPERTENSIONAHA.108.127290eng
hcfmusp.relation.referenceMoraes-Teixeira JD, 2010, EXP MOL PATHOL, V89, P351, DOI 10.1016/j.yexmp.2010.08.004eng
hcfmusp.relation.referenceMota Gustavo Augusto Ferreira, 2020, Cell Physiol Biochem, V54, P719, DOI 10.33594/000000251eng
hcfmusp.relation.referenceNakamura M, 2018, NAT REV CARDIOL, V15, P387, DOI 10.1038/s41569-018-0007-yeng
hcfmusp.relation.referenceNeubauer S, 2007, NEW ENGL J MED, V356, P1140, DOI 10.1056/NEJMra063052eng
hcfmusp.relation.referenceNiemi H, 2014, EUR J CLIN INVEST, V44, P989, DOI 10.1111/eci.12333eng
hcfmusp.relation.referenceOka S, 2015, CIRC-HEART FAIL, V8, P1123, DOI 10.1161/CIRCHEARTFAILURE.115.002216eng
hcfmusp.relation.referenceOka S, 2011, CELL METAB, V14, P598, DOI 10.1016/j.cmet.2011.10.001eng
hcfmusp.relation.referenceOka T, 2014, CIRC RES, V114, P565, DOI 10.1161/CIRCRESAHA.114.300507eng
hcfmusp.relation.referenceOsorio JC, 2002, CIRCULATION, V106, P606, DOI 10.1161/01.CIR.0000023531.22727.C1eng
hcfmusp.relation.referencePagan LU, 2021, FRONT PHYSIOL, V12, DOI 10.3389/fphys.2021.675778eng
hcfmusp.relation.referencePagan LU, 2015, CELL PHYSIOL BIOCHEM, V36, P61, DOI 10.1159/000374053eng
hcfmusp.relation.referencePonikowski P, 2016, EUR HEART J, V37, P2129, DOI 10.1093/eurheartj/ehw128eng
hcfmusp.relation.referenceReyes DRA, 2019, J CELL MOL MED, V23, P1235, DOI 10.1111/jcmm.14025eng
hcfmusp.relation.referenceRohde LEP, 2018, Arq Bras Cardiol, V111, P436, DOI [10.5935/abc.20180190, DOI 10.5935/ABC.20180190]eng
hcfmusp.relation.referencede Campos DHS, 2014, ARQ BRAS CARDIOL, V103, P330, DOI 10.5935/abc.20140135eng
hcfmusp.relation.referenceSant'Ana PG, 2023, INT J MOL SCI, V24, DOI 10.3390/ijms24076201eng
hcfmusp.relation.referenceSant'Ana Paula Grippa, 2018, Pathophysiology, V25, P373, DOI 10.1016/j.pathophys.2018.07.001eng
hcfmusp.relation.referenceShangguan RA, 2023, MOL BIOL REP, DOI 10.1007/s11033-022-08205-3eng
hcfmusp.relation.referenceShiojima I, 2005, J CLIN INVEST, V115, P2108, DOI 10.1172/JCI24682eng
hcfmusp.relation.referenceSilva MG, 2022, BIOLOGY-BASEL, V11, DOI 10.3390/biology11121750eng
hcfmusp.relation.referenceSmeets PJH, 2008, PHYSIOL GENOMICS, V36, P15, DOI 10.1152/physiolgenomics.90296.2008eng
hcfmusp.relation.referenceSouza RWA, 2014, PLOS ONE, V9, DOI 10.1371/journal.pone.0110020eng
hcfmusp.relation.referenceStolen T, 2020, SCAND CARDIOVASC J, V54, P84, DOI 10.1080/14017431.2019.1658893eng
hcfmusp.relation.referenceStrom CC, 2005, FEBS J, V272, P2684, DOI 10.1111/j.1742-4658.2005.04684.xeng
hcfmusp.relation.referencede Souza PAT, 2015, HISTOL HISTOPATHOL, V30, P801, DOI 10.14670/HH-11-581eng
hcfmusp.relation.referenceVileigas DF, 2021, J NUTR BIOCHEM, V92, DOI 10.1016/j.jnutbio.2021.108625eng
hcfmusp.relation.referenceWarren JS, 2017, AM J PHYSIOL-HEART C, V313, pH584, DOI 10.1152/ajpheart.00103.2017eng
hcfmusp.relation.referenceWeeks KL, 2012, CIRC-HEART FAIL, V5, P523, DOI 10.1161/CIRCHEARTFAILURE.112.966622eng
hcfmusp.relation.referenceWhite FC, 1998, J APPL PHYSIOL, V85, P1160, DOI 10.1152/jappl.1998.85.3.1160eng
hcfmusp.relation.referenceWisloff U, 2007, CIRCULATION, V115, P3086, DOI 10.1161/CIRCULATIONAHA.106.675041eng
hcfmusp.scopus.lastupdate2024-04-12
relation.isAuthorOfPublication55d2b9de-aad9-46f5-ae81-7d6247bcaafb
relation.isAuthorOfPublication.latestForDiscovery55d2b9de-aad9-46f5-ae81-7d6247bcaafb
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_SOUZA_Effects_of_early_exercise_on_cardiac_function_and_2023.PDF
Tamanho:
3.4 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - LIM/29
Artigos e Materiais de Revistas Científicas - ODS/03