First case report of monkeypox in Brazil: clinical manifestations and differential diagnosis with sexually transmitted infections

Imagem de Miniatura
Arquivos
art_LIMA_First_case_report_of_monkeypox_in_Brazil_clinical_2022.PDF (595.27 KB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2022
DOI
SciELO
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
INST MEDICINA TROPICAL SAO PAULO
Autores
LIMA, Evelyn Lepka de
BARRA, Luiz Alberto Costa
BORGES, Luciana Marques Sansao
MEDEIROS, Lucas Alberto
TOMISHIGE, Marcia Y. S.
SANTOS, Lucas de Souza Loureiro Abbud
SILVA, Anderson Jose Dias da
RODRIGUES, Camila Cristina Martini
AZEVEDO, Luiz Cesar Fernandes de
Citação
REVISTA DO INSTITUTO DE MEDICINA TROPICAL DE SAO PAULO, v.64, article ID e54, 7p, 2022
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
In 2022, an outbreak of monkeypox is being reported in non-endemic areas, with unusual clinical manifestations. The detailed clinical description of the first patient that received the diagnosis of monkeypox in Brazil is reported here, whose clinical manifestations can easily lead to misdiagnosis of sexually transmitted infections. A 41 years old male presented to an emergency room with a vesicular rash with eight days of evolution. He had traveled to Portugal and Spain and reported non-penetrative sexual involvement with three different male individuals. On the third day of symptoms, he sought medical care and received empirical treatment directed to sexually transmitted infections. As the symptoms did not improve, he sought medical attention at an infectious disease referral center presenting, on admission, an ulcerated penile lesion with central necrotic crusts, a disseminated pleomorphic skin rash and an oropharyngeal ulcer. The monkeypox diagnosis was suspected due to the characteristics of the lesions and the history of intimate contact with casual partners, and it was later confirmed by sequencing the almost complete monkeypox genome. The patient was hospitalized for pain control, which required opiate administration. He developed a secondary bacterial infection on the penile lesions, which were treated with oral antibiotics. He was discharged after 14 days, with lesions in process of re-epithelialization. Given the current outbreak, we must consider the possibility of monkeypox in patients with suggestive lesions, anywhere on the body (including the genitals), added to an epidemiological link or history of intimate contact with strangers or casual partners.
Palavras-chave
Monkeypox, Sexually transmitted diseases
URI
https://observatorio.fm.usp.br/handle/OPI/50539
Referências
  1. Adler Hugh, 2022, Lancet Infect Dis, V22, P1153, DOI 10.1016/S1473-3099(22)00228-6
  2. Antinori A, 2022, EUROSURVEILLANCE, V27, DOI 10.2807/1560-7917.ES.2022.27.22.2200421
  3. Bavarian Nordic, JYNNEOS
  4. Bragazzi NL., 2022, J MED VIROL
  5. Brasil. Agencia Nacional de Vigilancia Sanitaria, 2022, 032022 GVIMSGGTESDIR
  6. Brasil. Ministerio da Saude, 27 SVS MIN SAUD
  7. Claro IM, 2022, REV INST MED TROP SP, V64, DOI [10.1590/s1678-9946202264048, 10.1590/S1678-9946202264048]
  8. Emergent Product Development Gaithersburg, ACAM2000
  9. Gagnier JJ, 2013, DTSCH ARZTEBL INT, V110, P603, DOI [10.7453/gahmj.2013.008, 10.1186/1752-1947-7-223, 10.3238/arztebl.2013.0603, 10.1136/bcr-2013-201554]
  10. Heskin Joseph, 2022, J Infect, V85, P334, DOI 10.1016/j.jinf.2022.05.028
  11. Lee K, 2009, GLOB INST, P1
  12. McCollum AM, 2014, CLIN INFECT DIS, V58, P260, DOI 10.1093/cid/cit703
  13. O'Shea J, 2022, MMWR-MORBID MORTAL W, V71, P1023, DOI 10.15585/mmwr.mm7132e4
  14. Ogoina D, 2020, CLIN INFECT DIS, V71, pE210, DOI 10.1093/cid/ciaa143
  15. Petersen E, 2019, INFECT DIS CLIN N AM, V33, P1027, DOI 10.1016/j.idc.2019.03.001
  16. Philpott D, 2022, MMWR-MORBID MORTAL W, V71, P1018, DOI 10.15585/mmwr.mm7132e3
  17. Vranjac Alexandre, ALERTA EPIDEMIOLOGIC
  18. World Health Organization, MONK
  19. World Health Organization, PUBL HLTH ADV GAY BI
  20. World Health Organization (WHO), MULT MONK OUTBR SIT

Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/46
Artigos e Materiais de Revistas Científicas - LIM/49
Artigos e Materiais de Revistas Científicas - LIM/52