Peritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patients

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPINTO NETO, Nelson Inacio
dc.contributor.authorMURARI, Ariene Soares de Pinho
dc.contributor.authorOYAMA, Lila Missae
dc.contributor.authorOTOCH, Jose Pinhata
dc.contributor.authorALCANTARA, Paulo Sergio Martins
dc.contributor.authorTOKESHI, Flavio
dc.contributor.authorFIGUEREDO, Raquel Galvao
dc.contributor.authorALVES, Michele Joana
dc.contributor.authorLIMA, Joanna Darck Carola Correia
dc.contributor.authorMATOS-NETO, Emidio Marques de
dc.contributor.authorSEELAENDER, Marilia
dc.contributor.authorNASCIMENTO, Claudia Maria Oller do
dc.date.accessioned2019-01-17T13:27:32Z
dc.date.available2019-01-17T13:27:32Z
dc.date.issued2018
dc.description.abstractBackground Cancer cachexia (CC) is a multifactorial syndrome, often irreversible, that affects patients with cancer influenced, in part, by the inflammatory condition. Peritumoural adipose tissue produces adipokines and angiogenic, apoptotic, and growth factors; given the possible crosstalk between the peritumoural adipose tissue and tumour, these may play an important role in cancer biology and carcinogenesis. Methods Results The aim of this study was to evaluate the factors produced by peritumoural adipose tissue in a cohort of 16 colorectal cancer patients with either weight-stable cancer (WSC; n = 7) or CC (n = 9). The study was approved by the Ethics Research Committee (972.914). Samples of peritumoural adipose tissue were analysed for concentrations of TNF-alpha, IL-1 beta, STAT-1, STAT-3, RANTES, IL-1Ra, IP-10, IL-15, MCP-1, IFN-alpha, GCSF, FADD, and TGF-beta. The cytokines and proteins were measured using Multiplex. Correlations between the proteins and cytokines were evaluated. TNF-alpha, STAT-1, and FADD, a factor involved in apoptosis, were significantly higher in CC group than in the WSC group. In the peritumoural adipose tissue of the CC group, RANTES showed a significant positive correlation with IL-1Ra and IP-10 and a negative correlation with IFN-alpha; and GCSF showed significant negative correlations with IL-1Ra, IP-10, IL-15, and MCP-1 and a positive correlation with IFN-alpha. In the peritumoural adipose tissue of the WSC group, no significant correlations were detected between RANTES, GCSF, IL-3, FADD, and STAT-1 and the cytokines/chemokines analysed. Conclusions These results indicated that inflammatory and tumorigenic pathways were altered in peritumoural adipose tissue in CC. Furthermore, inflammatory cytokines were correlated with growth factors in the peritumoural adipose tissue of cachectic patients, suggesting that inflammatory cytokines modulated the proliferative environment closely linked to the tumour.eng
dc.description.indexMEDLINEeng
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/50079-0]
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico, Tecnologico (CNPq)
dc.description.sponsorshipCoordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES)
dc.description.sponsorshipCNPq
dc.identifier.citationJOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE, v.9, n.6, p.1101-1108, 2018
dc.identifier.doi10.1002/jcsm.12345
dc.identifier.issn2190-6009
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29788
dc.language.isoeng
dc.publisherWILEYeng
dc.relation.ispartofJournal of Cachexia Sarcopenia and Muscle
dc.rightsopenAccesseng
dc.rights.holderCopyright WILEYeng
dc.subjectPeritumoural adipose tissueeng
dc.subjectCancer cachexiaeng
dc.subjectCytokineseng
dc.subjectApoptosiseng
dc.subject.otherfactor g-csfeng
dc.subject.otherbreast-cancereng
dc.subject.othertnf-alphaeng
dc.subject.othercellseng
dc.subject.otherangiogenesiseng
dc.subject.othermacrophageseng
dc.subject.otherprogressioneng
dc.subject.otherendocrineeng
dc.subject.otherstat1eng
dc.subject.otherfaddeng
dc.subject.wosGeriatrics & Gerontologyeng
dc.subject.wosMedicine, General & Internaleng
dc.titlePeritumoural adipose tissue pro-inflammatory cytokines are associated with tumoural growth factors in cancer cachexia patientseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalPINTO NETO, Nelson Inacio:Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, Brazil
hcfmusp.author.externalOYAMA, Lila Missae:Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, Brazil
hcfmusp.author.externalFIGUEREDO, Raquel Galvao:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalALVES, Michele Joana:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalLIMA, Joanna Darck Carola Correia:Univ Sao Paulo, Inst Biomed Sci, Canc Metab Res Grp, Sao Paulo, Brazil
hcfmusp.author.externalMATOS-NETO, Emidio Marques de:Univ Fed Piaui, Dept Phys Educ, Piaui, Brazil
hcfmusp.author.externalNASCIMENTO, Claudia Maria Oller do:Univ Fed Sao Paulo, Dept Fisiol, Escola Paulista Med, Sao Paulo, Brazil
hcfmusp.citation.scopus24
hcfmusp.contributor.author-fmusphcARIENE MURARI SOARES DE PINHO
hcfmusp.contributor.author-fmusphcJOSE PINHATA OTOCH
hcfmusp.contributor.author-fmusphcPAULO SERGIO MARTINS DE ALCANTARA
hcfmusp.contributor.author-fmusphcFLAVIO TOKESHI
hcfmusp.contributor.author-fmusphcMARILIA CERQUEIRA LEITE SEELAENDER
hcfmusp.description.beginpage1101
hcfmusp.description.endpage1108
hcfmusp.description.issue6
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed30284380
hcfmusp.origem.scopus2-s2.0-85054319121
hcfmusp.origem.wosWOS:000450338100009
hcfmusp.publisher.cityHOBOKENeng
hcfmusp.publisher.countryUSAeng
hcfmusp.relation.referenceAmor S, 2016, INT J COLORECTAL DIS, V31, P365, DOI 10.1007/s00384-015-2420-6eng
hcfmusp.relation.referenceBatista ML, 2013, CYTOKINE, V61, P532, DOI 10.1016/j.cyto.2012.10.023eng
hcfmusp.relation.referenceBatista ML, 2012, J ENDOCRINOL, V215, P363, DOI 10.1530/JOE-12-0307eng
hcfmusp.relation.referenceBatista ML, 2016, J CACHEXIA SARCOPENI, V7, P37, DOI 10.1002/jcsm.12037eng
hcfmusp.relation.referenceBochet L, 2013, CANCER RES, V73, P5657, DOI 10.1158/0008-5472.CAN-13-0530eng
hcfmusp.relation.referenceCamargo RG, 2015, NUTRIENTS, V7, P4465, DOI 10.3390/nu7064465eng
hcfmusp.relation.referenceCho U, 2018, MOL CARCINOGEN, V57, P235, DOI 10.1002/mc.22750eng
hcfmusp.relation.referencede Matos-Neto EM, 2015, FRONT IMMUNOL, V6, DOI 10.3389/fimmu.2015.00629eng
hcfmusp.relation.referenceDewangan J, 2018, LIFE SCI, V193, P9, DOI 10.1016/j.lfs.2017.11.045eng
hcfmusp.relation.referenceDuckett CS, 2002, J CLIN INVEST, V109, P579, DOI 10.1172/JCI200215197eng
hcfmusp.relation.referenceEvans WJ, 2008, CLIN NUTR, V27, P793, DOI 10.1016/j.clnu.2008.06.013eng
hcfmusp.relation.referenceGiovannucci E, 1996, CANCER CAUSE CONTROL, V7, P253, DOI 10.1007/BF00051301eng
hcfmusp.relation.referenceGrivennikov SI, 2011, ANN RHEUM DIS, V70, pI104, DOI 10.1136/ard.2010.140145eng
hcfmusp.relation.referenceGuzik TJ, 2017, CARDIOVASC RES, V113, P1009, DOI 10.1093/cvr/cvx108eng
hcfmusp.relation.referenceHauner H, 2005, P NUTR SOC, V64, P163, DOI 10.1079/PNS2005428eng
hcfmusp.relation.referenceHix LM, 2013, J BIOL CHEM, V288, P11676, DOI 10.1074/jbc.M112.441402eng
hcfmusp.relation.referenceJedinak A, 2010, IMMUNOBIOLOGY, V215, P242, DOI 10.1016/j.imbio.2009.03.004eng
hcfmusp.relation.referenceKratochvill F, 2015, CELL REP, V12, P1902, DOI 10.1016/j.celrep.2015.08.033eng
hcfmusp.relation.referenceLee WM, 2001, CANCER LETT, V162, P155, DOI 10.1016/S0304-3835(00)00635-2eng
hcfmusp.relation.referenceLiang GY, 2013, WORLD J SURG ONCOL, V11, DOI 10.1186/1477-7819-11-199eng
hcfmusp.relation.referenceLysaght J, 2011, CANCER LETT, V312, P62, DOI 10.1016/j.canlet.2011.07.034eng
hcfmusp.relation.referenceMalashchenko VV, 2018, CELL IMMUNOL, V325, P23, DOI 10.1016/j.cellimm.2018.01.007eng
hcfmusp.relation.referenceMarikar FMMT, 2016, CHIN CLIN ONCOL, V5, DOI 10.21037/cco.2016.11.03eng
hcfmusp.relation.referenceMeissl K, 2017, CYTOKINE, V89, P12, DOI 10.1016/j.cyto.2015.11.011eng
hcfmusp.relation.referenceMichalaki V, 2004, BRIT J CANCER, V90, P2312, DOI 10.1038/sj.bjc.6601814eng
hcfmusp.relation.referenceNgiow SF, 2013, TRENDS IMMUNOL, V34, P548, DOI 10.1016/j.it.2013.07.004eng
hcfmusp.relation.referencePark J, 2011, ENDOCR REV, V32, P550, DOI 10.1210/er.2010-0030eng
hcfmusp.relation.referencePatel HJ, 2017, LIFE SCI, V170, P56, DOI 10.1016/j.lfs.2016.11.033eng
hcfmusp.relation.referenceShiono M, 2016, CANCER MED-US, V5, P2641, DOI 10.1002/cam4.841eng
hcfmusp.relation.referenceSiegel R, 2012, CA-CANCER J CLIN, V62, P10, DOI 10.3322/caac.20138eng
hcfmusp.relation.referenceTrayhurn P, 2005, ACTA PHYSIOL SCAND, V184, P285, DOI 10.1111/j.1365-201X.2005.01468.xeng
hcfmusp.relation.referenceTsai RK, 2010, EXP EYE RES, V90, P537, DOI 10.1016/j.exer.2010.01.004eng
hcfmusp.relation.referenceTsoli M, 2016, SEMIN CELL DEV BIOL, V54, P68, DOI 10.1016/j.semcdb.2015.10.039eng
hcfmusp.relation.referencevon Haehling S, 2017, J CACHEXIA SARCOPENI, V8, P1081, DOI 10.1002/jcsm.12261eng
hcfmusp.relation.referenceWagner M, 2012, ANGIOGENESIS, V15, P481, DOI 10.1007/s10456-012-9276-yeng
hcfmusp.relation.referenceWang N, 2014, FRONT IMMUNOL, V5, DOI 10.3389/fimmu.2014.00614eng
hcfmusp.relation.referenceWhipple Chery A, 2015, Cancer Cell Microenviron, V2, pe773eng
hcfmusp.relation.referenceZhang QX, 1997, J SURG RES, V67, P147, DOI 10.1006/jsre.1996.4983eng
hcfmusp.relation.referenceZhang R, 2017, ONCOL LETT, V13, P1899, DOI 10.3892/ol.2017.5636eng
hcfmusp.relation.referenceZhong W, 2017, ONCOTARGET, V8, P73693, DOI 10.18632/oncotarget.17793eng
hcfmusp.relation.referenceZoico E, 2017, OBESITY, V25, pS87, DOI 10.1002/oby.22008eng
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublicationa3feb585-87ff-4a59-8934-9258218aca2e
relation.isAuthorOfPublication67273b45-147c-41d9-8c3b-5bce1cc4eb7b
relation.isAuthorOfPublication3e3c88a6-e279-4219-a5ab-da7c730ff800
relation.isAuthorOfPublicatione116dc85-3984-4479-a308-6d58308af603
relation.isAuthorOfPublication869a4134-d6d4-475f-bcd8-dd1852faa808
relation.isAuthorOfPublication.latestForDiscoverya3feb585-87ff-4a59-8934-9258218aca2e
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Imagem de Miniatura
Nome:
art_PINTO NETO_Peritumoural_adipose_tissue_proinflammatory_cytokines_are_associated_with_2018.PDF
Tamanho:
217.38 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HU
Artigos e Materiais de Revistas Científicas - LIM/26
Artigos e Materiais de Revistas Científicas - ODS/03