Human Bone Morphogenetic Protein-2 Use for Maxillary Reconstruction in Cleft Lip and Palate Patients

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCANAN JR., Lady Wilson
dc.contributor.authorFREITAS, Renato da Silva
dc.contributor.authorALONSO, Nivaldo
dc.contributor.authorTANIKAWA, Daniela Yukie Sakai
dc.contributor.authorROCHA, Diogenes Laercio
dc.contributor.authorCOELHO, Julio Cezar Uili
dc.date.accessioned2013-07-30T14:39:07Z
dc.date.available2013-07-30T14:39:07Z
dc.date.issued2012
dc.description.abstractBackground: The conventional methods of maxillary alveolar reconstruction in patient with cleft are the periosteoplasty and autologous bone grafting. As an important alternative of bone substitution, there is the recombinant human bone morphogenetic protein-2 (rhBMP-2). This study compares the rhBMP-2 with periosteoplasty and autologous bone grafting. Methods: Patients with cleft and alveolar defect were divided into 3 groups of 6 patients who underwent to autologous iliac crest bone grafting, resorbable collagen sponge with rhBMP2, and periosteoplasty, respectively. The analysis was performed through computed tomographic scan preoperatively and at months 3, 6, and 12 postoperatively. The variables analyzed were the alveolar defect volume, formed bone volume, bone formation rate, maxillary height repair rate, and the formed bone density mean. Results: The formed bone volume was similar comparing the bone graft and BMP groups at 1-year postoperative analysis (P = 0.58). Both of them had the formed bone volume significantly larger than the periosteoplasty group at 3 and 6 months postoperatively. In this last group, the 1-year follow-up was canceled because the bone formation was insufficient. The bone formation rate, the maxillary height repair rate, and the mean of density of the formed bone were similar in the bone graft and BMP groups at 1-year follow-up with P values of 0.93, 0.90, and 0.81, respectively. Conclusions: The amount of formed bone in the periosteoplasty group was insufficient. There was no difference among the bone graft and rhBMP-2 therapy considering the parameters analyzed.
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF CRANIOFACIAL SURGERY, v.23, n.6, p.1627-1633, 2012
dc.identifier.doi10.1097/SCS.0b013e31825c75ba
dc.identifier.issn1049-2275
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/354
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofJournal of Craniofacial Surgery
dc.rightsrestrictedAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectBone morphogenetic protein
dc.subjectcleft lip and palate
dc.subjectalveolar bone grafting
dc.subject.otheralveolar clefts
dc.subject.otherunilateral clefts
dc.subject.otherradiographic outcomes
dc.subject.othergingivoperiosteoplasty
dc.subject.othergrowth
dc.subject.othergrafts
dc.subject.otherperiosteoplasty
dc.subject.otherdefects
dc.subject.othersuccess
dc.subject.otherrepair
dc.subject.wosSurgery
dc.titleHuman Bone Morphogenetic Protein-2 Use for Maxillary Reconstruction in Cleft Lip and Palate Patients
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCANAN JR., Lady Wilson:Assistance Ctr Cleft Lip & Palate CAIF, BR-81050000 Curitiba, Parana, Brazil
hcfmusp.author.externalFREITAS, Renato da Silva:Assistance Ctr Cleft Lip & Palate CAIF, BR-81050000 Curitiba, Parana, Brazil
hcfmusp.author.externalCOELHO, Julio Cezar Uili:Univ Fed Parana, BR-80060000 Curitiba, Parana, Brazil
hcfmusp.citation.scopus57
hcfmusp.contributor.author-fmusphcNIVALDO ALONSO
hcfmusp.contributor.author-fmusphcDANIELA YUKIE SAKAI TANIKAWA
hcfmusp.contributor.author-fmusphcDIOGENES LAERCIO ROCHA
hcfmusp.description.beginpage1627
hcfmusp.description.endpage1633
hcfmusp.description.issue6
hcfmusp.description.volume23
hcfmusp.lim.ref2012
hcfmusp.origemWOS
hcfmusp.origem.pubmed23147291
hcfmusp.origem.scopus2-s2.0-84873316613
hcfmusp.origem.wosWOS:000311889300064
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
hcfmusp.relation.referenceAamodt A, 1999, J BONE JOINT SURG BR, V81B, P143, DOI 10.1302/0301-620X.81B1.8880
hcfmusp.relation.referenceABYHOLM FE, 1981, SCAND J PLAST RECONS, V15, P15
hcfmusp.relation.referenceAlonso N, 2010, TISSUE ENG PART C-ME, V16, P1183, DOI 10.1089/ten.TEC.2009.0824
hcfmusp.relation.referenceBoyne P J, 1997, Int J Periodontics Restorative Dent, V17, P11
hcfmusp.relation.referenceBOYNE PJ, 1972, J ORAL SURG, V30, P87
hcfmusp.relation.referenceBoyne PJ, 1998, BRIT J ORAL MAX SURG, V36, P84, DOI 10.1016/S0266-4356(98)90173-5
hcfmusp.relation.referenceBOYNE PJ, 1974, J DENT RES, V53, P821, DOI 10.1177/00220345740530040901
hcfmusp.relation.referenceCarstens MH, 2005, J CRANIOFAC SURG, V16, P1023, DOI 10.1097/01.scs.0000186310.10957.2b
hcfmusp.relation.referenceChin M, 2005, J CRANIOFAC SURG, V16, P778, DOI 10.1097/01.scs.0000166802.49021.01
hcfmusp.relation.referenceCho YR, 2004, CLIN PLAST SURG, V31, P377, DOI 10.1016/j.cps.2004.03.001
hcfmusp.relation.referenceDickinson BP, 2008, PLAST RECONSTR SURG, V121, P209, DOI 10.1097/01.prs.0000293870.64781.12
hcfmusp.relation.referenceEinhorn TA, 2003, J BONE JOINT SURG AM, V85A, P82
hcfmusp.relation.referenceENEMARK H, 1987, J ORAL MAXIL SURG, V45, P913, DOI 10.1016/0278-2391(87)90439-3
hcfmusp.relation.referenceFallucco MA, 2009, J CRANIOFAC SURG, V20, P1759, DOI 10.1097/SCS.0b013e3181b5d08e
hcfmusp.relation.referenceFeichtinger M, 2006, J CRANIO MAXILL SURG, V34, P144, DOI 10.1016/j.jcms.2005.11.005
hcfmusp.relation.referenceHellquist R, 1982, Swed Dent J Suppl, V15, P79
hcfmusp.relation.referenceHELLQUIST R, 1983, CLEFT PALATE J, V20, P277
hcfmusp.relation.referenceHELLQUIST R, 1976, SCAND J PLAST RECONS, V10, P197
hcfmusp.relation.referenceHerford AS, 2007, J ORAL MAXIL SURG, V65, P2136, DOI 10.1016/j.jams.2007.06.670
hcfmusp.relation.referenceHonma K, 1999, J ORAL MAXIL SURG, V57, P1209, DOI 10.1016/S0278-2391(99)90488-3
hcfmusp.relation.referenceKORTEBEIN MJ, 1991, J ORAL MAXIL SURG, V49, P493, DOI 10.1016/0278-2391(91)90172-I
hcfmusp.relation.referenceMatic DB, 2008, PLAST RECONSTR SURG, V121, P1343, DOI 10.1097/01.prs.0000304604.89450.ae
hcfmusp.relation.referenceMatic DB, 2008, PLAST RECONSTR SURG, V122, P863, DOI 10.1097/PRS.0b013e3181811a6d
hcfmusp.relation.referenceMeazzini MC, 2008, SCAND J PLAST RECONS, V42, P290, DOI 10.1080/02844310802091628
hcfmusp.relation.referenceModolin M, 1996, TREATMENT OF CLEFT L, P13
hcfmusp.relation.referenceOberoi S, 2009, CLEFT PALATE-CRAN J, V46, P503, DOI 10.1597/08-153.1
hcfmusp.relation.referencePfeifer TM, 2002, CLEFT PALATE-CRAN J, V39, P26, DOI 10.1597/1545-1569(2002)039<0026:NMAGVA>2.0.CO;2
hcfmusp.relation.referenceRoss R B, 1987, Cleft Palate J, V24, P5
hcfmusp.relation.referenceSalyer KE, 2009, J CRANIOFAC SURG, V20, P1765, DOI 10.1097/SCS.0b013e3181b5d0af
hcfmusp.relation.referenceSantiago PE, 1998, CLEFT PALATE-CRAN J, V35, P77, DOI 10.1597/1545-1569(1998)035<0077:RNFABG>2.3.CO;2
hcfmusp.relation.referenceSato Y, 2008, PLAST RECONSTR SURG, V121, P1356, DOI 10.1097/01.prs.0000302461.56820.c9
hcfmusp.relation.referenceSchliephake H, 2002, INT J ORAL MAX SURG, V31, P469, DOI 10.1054/ijom.2002.0244
hcfmusp.relation.referenceSEMB G, 1988, CLEFT PALATE J, V25, P288
hcfmusp.relation.referenceSkoog T, 1965, Cleft Palate J, V2, P332
hcfmusp.relation.referenceURIST MR, 1965, SCIENCE, V150, P893, DOI 10.1126/science.150.3698.893
hcfmusp.scopus.lastupdate2024-05-10
relation.isAuthorOfPublication15477aea-4408-4b6d-8c22-510df29a2dce
relation.isAuthorOfPublication9910369e-8356-48e6-8d2d-267ffee52598
relation.isAuthorOfPublication446df010-e58d-4722-a2c4-34e475e1fbc7
relation.isAuthorOfPublication.latestForDiscovery15477aea-4408-4b6d-8c22-510df29a2dce
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_ALONSO_Human_Bone_Morphogenetic_Protein_2_Use_for_Maxillary_2012_eng.pdf
Tamanho:
512 KB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - LIM/04