A subtest analysis of the Montreal cognitive assessment (MoCA): which subtests can best discriminate between healthy controls, mild cognitive impairment and Alzheimer's disease?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCECATO, Juliana Francisco
dc.contributor.authorMARTINELLI, Jose Eduardo
dc.contributor.authorIZBICKI, Rafael
dc.contributor.authorYASSUDA, Monica Sanches
dc.contributor.authorAPRAHAMIAN, Ivan
dc.date.accessioned2016-07-18T12:43:25Z
dc.date.available2016-07-18T12:43:25Z
dc.date.issued2016
dc.description.abstractBackground: It is necessary to continue to explore the psychometric characteristics of key cognitive screening tests such as the Montreal Cognitive Assessment (MoCA) to diagnose cognitive decline as early as possible and to attend to the growing need of clinical trials involving mild cognitive impairment (MCI) participants. The main aim of this study was to assess which MoCA subtests could best discriminate between healthy controls (HC), participants with MCI, and Alzheimer's disease (AD). Methods: Cross-sectional analysis of 136 elderly with more than four years of education. All participants were submitted to detailed clinical, laboratory, and neuroimaging evaluation. The MoCA, Mini-Mental State Examination (MMSE), the Cambridge Cognitive Examination (CAMCOG), Geriatric Depression Scale (GDS), and Functional Activities Questionnaire (FAQ) were applied to all participants. The MoCA test was not used in the diagnostic procedure. Results: Median MoCA total scores were 27, 23 and 18 for HC, MCI, and AD, respectively (p < 0.001). Word repetition, inverse digits, serial 7, phrases, verbal fluency, abstraction, and word recall discriminated between MCI and HC participants (p < 0.001). The clock drawing, the rhino naming, delayed recall of five words and orientation discriminated between patients with MCI and AD (p < 0.001). A reduced version of the MoCA with only these items did not improve accuracy between MCI and HC (p = 0.076) or MCI and AD (p = 0.119). Conclusions: Not all MoCA subtests might be fundamental to clinical diagnosis of MCI. The reduced versions of MoCA did not add diagnostic accuracy.
dc.description.indexMEDLINE
dc.identifier.citationINTERNATIONAL PSYCHOGERIATRICS, v.28, n.5, p.825-832, 2016
dc.identifier.doi10.1017/S1041610215001982
dc.identifier.eissn1741-203X
dc.identifier.issn1041-6102
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/14554
dc.language.isoeng
dc.publisherCAMBRIDGE UNIV PRESS
dc.relation.ispartofInternational Psychogeriatrics
dc.rightsrestrictedAccess
dc.rights.holderCopyright CAMBRIDGE UNIV PRESS
dc.subjectmild cognitive impairment diagnosis
dc.subjectAlzheimer's disease
dc.subjectcognitive assessment
dc.subjectcognitive testing
dc.subject.othermini-mental-state
dc.subject.otherassociation workgroups
dc.subject.otherscreening instruments
dc.subject.otherdiagnostic guidelines
dc.subject.othernational institute
dc.subject.otherolder-adults
dc.subject.othervalidation
dc.subject.otherdementia
dc.subject.otherrecommendations
dc.subject.otherpopulation
dc.subject.wosPsychology, Clinical
dc.subject.wosGeriatrics & Gerontology
dc.subject.wosGerontology
dc.subject.wosPsychiatry
dc.subject.wosPsychology
dc.titleA subtest analysis of the Montreal cognitive assessment (MoCA): which subtests can best discriminate between healthy controls, mild cognitive impairment and Alzheimer's disease?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCECATO, Juliana Francisco:Fac Med Jundiai, Dept Internal Med, Rua Francisco Telles 250, BR-13202550 Jundiai, SP, Brazil
hcfmusp.author.externalMARTINELLI, Jose Eduardo:Fac Med Jundiai, Dept Internal Med, Rua Francisco Telles 250, BR-13202550 Jundiai, SP, Brazil
hcfmusp.author.externalIZBICKI, Rafael:Univ Fed Sao Carlos, Dept Stat, BR-13560 Sao Carlos, SP, Brazil
hcfmusp.citation.scopus41
hcfmusp.contributor.author-fmusphcMONICA SANCHES YASSUDA
hcfmusp.contributor.author-fmusphcIVAN APRAHAMIAN
hcfmusp.description.beginpage825
hcfmusp.description.endpage832
hcfmusp.description.issue5
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed26620850
hcfmusp.origem.scopus2-s2.0-84948952636
hcfmusp.origem.wosWOS:000374169300014
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-04-12
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