Exposure to wildfire-related PM2.5 and sitespecific cancer mortality in Brazil from 2010 to 2016: A retrospective study

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorYU, Pei
dc.contributor.authorXU, Rongbin
dc.contributor.authorLI, Shanshan
dc.contributor.authorYUE, Xu
dc.contributor.authorCHEN, Gongbo
dc.contributor.authorYE, Tingting
dc.contributor.authorCOELHO, Micheline S. Z. S.
dc.contributor.authorSALDIVA, Paulo H. N.
dc.contributor.authorSIM, Malcolm R.
dc.contributor.authorABRAMSON, Michael J.
dc.contributor.authorGUO, Yuming
dc.date.accessioned2023-02-23T14:57:41Z
dc.date.available2023-02-23T14:57:41Z
dc.date.issued2022
dc.description.abstractBackground Long-term exposure to fine particles <= 2.5 mu m in diameter (PM2.5) has been linked to cancer mortality. However, the effect of wildfire-related PM2.5 exposure on cancer mortality risk is unknown. This study evaluates the association between wildfire-related PM2.5 and site-specific cancer mortality in Brazil, from 2010 to 2016. Methods and findings Nationwide cancer death records were collected during 2010-2016 from the Brazilian Mortality Information System. Death records were linked with municipal-level wildfire- and nonwildfire-related PM2.5 concentrations, at a resolution of 2.0 degrees latitude by 2.5 degrees longitude. We applied a variant difference-in-differences approach with quasi-Poisson regression, adjusting for seasonal temperature and gross domestic product (GDP) per capita. Relative risks (RRs) and 95% confidence intervals (CIs) for the exposure for specific cancer sites were estimated. Attributable fractions and cancer deaths were also calculated. In total, 1,332,526 adult cancer deaths (age >= 20 years), from 5,565 Brazilian municipalities, covering 136 million adults were included. The mean annual wildfire-related PM2.5 concentration was 2.38 mu g/m(3), and the annual non-wildfire-related PM2.5 concentration was 8.20 mu g/m(3). The RR for mortality from all cancers was 1.02 (95% CI 1.01-1.03, p< 0.001) per mu g/m(3) increase of wildfire-related PM2.5 concentration, which was higher than the RR per 1-mu g/m(3) increase of non-wildfire-related PM2.5 (1.01 [95% CI 1.00-1.01], p = 0.007, with p for difference = 0.003). Wildfire-related PM2.5 was associated with mortality from cancers of the nasopharynx (1.10 [95% CI 1.04-1.16], p = 0.002), esophagus (1.05 [95% CI 1.01-1.08], p = 0.012), stomach (1.03 [95% CI 1.01-1.06], p = 0.017), colon/rectum (1.08 [95% CI 1.05-1.11], p < 0.001), larynx (1.06 [95% CI 1.02-1.11], p = 0.003), skin (1.06 [95% CI 1.001.12], p = 0.003), breast (1.04 [95% CI 1.01-1.06], p = 0.007), prostate (1.03 [95% CI 1.011.06], p = 0.019), and testis (1.10 [95% CI 1.03-1.17], p = 0.002). For all cancers combined, the attributable deaths were 37 per 100,000 population and ranged from 18/100,000 in the Northeast Region of Brazil to 71/100,000 in the Central-West Region. Study limitations included a potential lack of assessment of the joint effects of gaseous pollutants, an inability to capture the migration of residents, and an inability to adjust for some potential confounders. Conclusions Exposure to wildfire-related PM2.5 can increase the risks of cancer mcaoprttuarlietyyofourrmmeaannyincga:Infncoetr; pleaseprovidecorrectwording: sites, and the effect for wildfire-related PM2.5 was higher than for PM2.5 from non-wildfire sources.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipAustralian Research Council [DP210102076]
dc.description.sponsorshipAustralian National Health and Medical Research Council [GNT2000581]
dc.description.sponsorshipChina Scholarship Council funds [201906210065, 201806010405, 201906320051]
dc.description.sponsorshipEmerging Leader Fellowship of the Australian National Health and Medical Research Council [APP2009866, APP1163693, APP2008813]
dc.identifier.citationPLOS MEDICINE, v.19, n.9, article ID e1004103, 21p, 2022
dc.identifier.doi10.1371/journal.pmed.1004103
dc.identifier.eissn1549-1676
dc.identifier.issn1549-1277
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51620
dc.language.isoeng
dc.publisherPUBLIC LIBRARY SCIENCEeng
dc.relation.ispartofPlos Medicine
dc.rightsopenAccesseng
dc.rights.holderCopyright PUBLIC LIBRARY SCIENCEeng
dc.subject.otherair-pollutioneng
dc.subject.otherparticulate mattereng
dc.subject.otheroxidative stresseng
dc.subject.otherlung-cancereng
dc.subject.othersmokeeng
dc.subject.otherriskeng
dc.subject.otherinflammationeng
dc.subject.othertemperatureeng
dc.subject.otheresophagealeng
dc.subject.othersurvivaleng
dc.subject.wosMedicine, General & Internaleng
dc.titleExposure to wildfire-related PM2.5 and sitespecific cancer mortality in Brazil from 2010 to 2016: A retrospective studyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryAustrália
hcfmusp.affiliation.countryChina
hcfmusp.affiliation.countryisoau
hcfmusp.affiliation.countryisocn
hcfmusp.author.externalYU, Pei:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalXU, Rongbin:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalLI, Shanshan:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalYUE, Xu:Nanjing Univ Informat Sci & Technol, Jiangsu Key Lab Atmospher Environm Monitoring & P, Collaborat Innovat Ctr Atmospher Environm & Equip, Sch Environm Sci & Engn, Nanjing, Peoples R China
hcfmusp.author.externalCHEN, Gongbo:Sun Yat Sen Univ, Guangzhou Key Lab Environm Pollut & Hlth Risk Ass, Guangdong Prov Engn Technol Res Ctr Environm Poll, Dept Occupat & Environm Hlth,Sch Publ Hlth, Guangzhou, Peoples R China
hcfmusp.author.externalYE, Tingting:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalSIM, Malcolm R.:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalABRAMSON, Michael J.:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.author.externalGUO, Yuming:Monash Univ, Sch Publ Hlth & Prevent Med, Melbourne, Vic, Australia
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcMICHELINE DE SOUSA ZANOTTI STAGLIORIO COELHO
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.description.articlenumbere1004103
hcfmusp.description.issue9
hcfmusp.description.volume19
hcfmusp.origemWOS
hcfmusp.origem.pubmed36121854
hcfmusp.origem.scopus2-s2.0-85139571002
hcfmusp.origem.wosWOS:000911205600006
hcfmusp.publisher.citySAN FRANCISCOeng
hcfmusp.publisher.countryUSAeng
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