Decreased Brain-Derived Neurotrophic Factor in Older Adults with Bipolar Disorder

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art_SOARES_Decreased_BrainDerived_Neurotrophic_Factor_in_Older_Adults_with_2016.PDF (298.2 KB)
Citações na Scopus
20
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE INC
Autores
ANDREAZZA, Ana C.
REJ, Soham
RAJJI, Tarek K.
GILDENGERS, Ariel G.
YOUNG, L. Trevor
MULSANT, Benoit H.
Citação
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY, v.24, n.8, p.596-601, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objectives: Decreased levels of brain derived neurotrophic factor (BDNF) have been found in adult patients with bipolar disorder (BD) compared with a comparison group, yet there are no data specifically examining this in geriatric patients. The objective of this study was to examine whether euthymic late-life BD patients have lower BDNF levels than healthy comparators. Design: Cross-sectional study. Setting: Clinics at the University of Pittsburgh and the Centre for Addiction and Mental Health (Toronto). Participants: Older patients with BD (age >= 50 years, N = 118) and similarly aged healthy comparators (N = 76). There were both BD type I (N = 91) and type II (N = 27) patients. Measurements: Serum BDNF levels were assessed in BD patients and healthy comparators. Results: We found lower levels of BDNF in patients with BD than in healthy comparators (9.0 +/- 6.2 versus 12.3 +/- 8.9 pg/mu g, t((192)) = -3.01, p = 0.002), which remained even after controlling for age, sex, lithium use, and site (F-(1,F-176) = 4.32, p = 0.039). This decrease was found specifically in patients with BD type I (8.0 +/- 5.5 versus 12.3 +/- 8.9 pg/mu g, t((165)) = 3.7, Bonferroni p < 0.001), but not type II (12.0 +/- 7.5 versus 12.3 +/- 8.9 pg/mu g, t((101)) = 0.14, Bonferroni p = 1.0). Conclusions: Older patients with BD have lower serum levels of BDNF compared with similarly aged comparators. These effects appear to be specific to patients with BD type I. Future studies are needed to investigate the impact of reduced BDNF levels on cognition, mood, and other aspects of BD throughout the life course.
Palavras-chave
bipolar disorder, brain-derived neurotrophic factor, aging, elderly
URI
https://observatorio.fm.usp.br/handle/OPI/21998
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/21