Cut-off values of the Johnsen score and Copenhagen index as histopathological prognostic factors for postoperative semen quality in selected infertile patients undergoing microsurgical correction of bilateral subclinical varicocele

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTEIXEIRA, Thiago Afonso
dc.contributor.authorPARIZ, Juliana Risso
dc.contributor.authorDUTRA, Robertson Torres
dc.contributor.authorSALDIVA, Paulo Hilario
dc.contributor.authorCOSTA, Elaine
dc.contributor.authorHALLAK, Jorge
dc.date.accessioned2019-09-23T14:20:31Z
dc.date.available2019-09-23T14:20:31Z
dc.date.issued2019
dc.description.abstractBackground: It remains challenging to determine which individuals are likely to benefit from microsurgical correction of subclinical varicocele, as basic semen parameters often do not improve postoperatively. We aimed to develop an easily accessible tool for prognostic stratification of infertile men indicated for microsurgical correction of bilateral subclinical varicocele characterized by prolonged and clear venous reflux and no other cause for infertility. Methods: We retrospectively analyzed the testicular biopsy, seminal analysis, and ultrasound evaluation records of 20 men managed between 2006 and 2014. Subclinical varicocele was diagnosed through bilateral testicular palpation and auscultation of venous reflux using a Doppler stethoscope, with confirmation on color Doppler sonography. We conducted receiver operating characteristic curve analysis to identify the optimal combinations of cut-offs for the Johnsen score, Copenhagen index, and testicular volume defining histological patterns with positive prognostic value for improved postoperatively reproductive capacity. Results: Positive prognostic value was noted for the following combinations of parameters: (I) Johnsen score >8.2 in the left testicle and right testicular volume >12.8 mL predicted improved sperm concentration; (II) Johnsen score >8.2 and Copenhagen index digit II <2.5 bilaterally predicted improved total sperm motility; (III) Johnsen score >9.1 and Copenhagen index digit III <1.5 bilaterally predicted improved progressive sperm motility; (IV) Johnsen score >7.9 and right testicular volume >13.6 mL predicted improved sperm morphology. Conclusions: Johnsen score and Copenhagen index as histopathological prognostic factors can be easily obtained upon evaluation of testicular biopsy specimens and can be simple and reliable tool to establish a more realistic prognosis for reproductive capacity in men who undergo microsurgical correction of subclinical varicocele with no other detectable cause for infertility.eng
dc.description.indexPubMedeng
dc.identifier.citationTRANSLATIONAL ANDROLOGY AND UROLOGY, v.8, n.4, p.346-355, 2019
dc.identifier.doi10.21037/tau.2019.06.23
dc.identifier.eissn2223-4691
dc.identifier.issn2223-4683
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/33568
dc.language.isoeng
dc.publisherAME PUBL COeng
dc.relation.ispartofTranslational Andrology and Urology
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright AME PUBL COeng
dc.subjectTesticular biopsyeng
dc.subjectsubclinical varicoceleeng
dc.subjectseminal parameterseng
dc.subjectmicrosurgeryeng
dc.subjectmale infertilityeng
dc.subject.othertesticular biopsyeng
dc.subject.othermeneng
dc.subject.othertestiseng
dc.subject.otherpathophysiologyeng
dc.subject.otherultrasoundeng
dc.subject.otherpredictioneng
dc.subject.otherfertilityeng
dc.subject.othersizeeng
dc.subject.othereraeng
dc.subject.wosAndrologyeng
dc.subject.wosUrology & Nephrologyeng
dc.titleCut-off values of the Johnsen score and Copenhagen index as histopathological prognostic factors for postoperative semen quality in selected infertile patients undergoing microsurgical correction of bilateral subclinical varicoceleeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalDUTRA, Robertson Torres:Univ Sao Paulo, Inst Adv Studies, Div Urol, Sao Paulo, Brazil; Univ Sao Paulo, Dept Pathol, Reprod Toxicol Unit, Sao Paulo, Brazil
hcfmusp.author.externalCOSTA, Elaine:Univ Sao Paulo, Inst Adv Studies, Mens Hlth Study Grp, Sao Paulo, Brazil; Androsci Sci & Innovat Ctr, Oaqu Floriano St,533 Cj 9 4, BR-04534011 Sao Paulo, SP, Brazil; Androsci Sci & Innovat Ctr, High Complex Clin & Res Androl Lab, Oaqu Floriano St,533 Cj 9 4, BR-04534011 Sao Paulo, SP, Brazil; Univ Sao Paulo, Div Endocrinol, Sao Paulo, Brazil
hcfmusp.citation.scopus17
hcfmusp.contributor.author-fmusphcTHIAGO AFONSO CARVALHO CELESTINO TEIXEIRA
hcfmusp.contributor.author-fmusphcJULIANA RISSO PARIZ
hcfmusp.contributor.author-fmusphcPAULO HILARIO NASCIMENTO SALDIVA
hcfmusp.contributor.author-fmusphcJORGE HALLAK
hcfmusp.description.beginpage346
hcfmusp.description.endpage355
hcfmusp.description.issue4
hcfmusp.description.volume8
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-85072108713
hcfmusp.origem.wosWOS:000482228700010
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hcfmusp.publisher.countryPEOPLES R CHINAeng
hcfmusp.relation.referenceAnawalt BD, 2013, J CLIN ENDOCR METAB, V98, P3532, DOI 10.1210/jc.2012-2400eng
hcfmusp.relation.referenceAthayde KS, 2007, J ANDROL, V28, P613, DOI 10.2164/jandrol.106.001966eng
hcfmusp.relation.referenceBarazani Y, 2011, FERTIL STERIL, V95, P487, DOI 10.1016/j.fertnstert.2010.11.058eng
hcfmusp.relation.referenceBryniarski P, 2013, CENT EUR J UROL, V66, P56, DOI 10.5173/ceju.2013.01.art18eng
hcfmusp.relation.referenceCantoro U, 2015, UROLOGY, V85, P826, DOI 10.1016/j.urology.2015.01.015eng
hcfmusp.relation.referenceChen SS, 2017, ANDROLOGIA, V49, P5eng
hcfmusp.relation.referenceCito G, 2018, UROLOGIA J, V85, P60, DOI 10.1177/0391560318758940eng
hcfmusp.relation.referenceCocuzza M, 2008, FERTIL STERIL, V90, P1103, DOI 10.1016/j.fertnstert.2007.07.1377eng
hcfmusp.relation.referenceCocuzza M, 2010, FERTIL STERIL, V93, P2396, DOI 10.1016/j.fertnstert.2009.01.088eng
hcfmusp.relation.referenceCocuzza M, 2009, FERTIL STERIL, V91, P925, DOI 10.1016/j.fertnstert.2007.12.065eng
hcfmusp.relation.referenceCondorelli R, 2013, INT J ENDOCRINOL, DOI 10.1155/2013/145792eng
hcfmusp.relation.referenceDHABUWALA CB, 1989, INT J ANDROL, V12, P430, DOI 10.1111/j.1365-2605.1989.tb01333.xeng
hcfmusp.relation.referenceDUBIN L, 1970, FERTIL STERIL, V21, P606eng
hcfmusp.relation.referenceElbendary MA, 2009, FERTIL STERIL, V92, P2050, DOI 10.1016/j.fertnstert.2009.05.069eng
hcfmusp.relation.referenceWorld Medical Association, 2013, JAMA, V310, P2191, DOI 10.1001/jama.2013.281053eng
hcfmusp.relation.referenceGORDON DL, 1965, FERTIL STERIL, V16, P522eng
hcfmusp.relation.referenceHallak J, 2001, UROLOGY, V58, P446, DOI 10.1016/S0090-4295(01)01224-9eng
hcfmusp.relation.referenceHallak J, 2017, TRANSL ANDROL UROL, V6, pS509, DOI 10.21037/tau.2017.06.29eng
hcfmusp.relation.referenceHallak J, 2016, ASIAN J ANDROL, V18, P315, DOI 10.4103/1008-682X.172645eng
hcfmusp.relation.referenceHayden RP, 2016, UROL CLIN N AM, V43, P223, DOI 10.1016/j.ucl.2016.01.009eng
hcfmusp.relation.referenceJOHNSEN S G, 1970, Hormones (Basel), V1, P2, DOI 10.1159/000178170eng
hcfmusp.relation.referenceJungwirth A, 2012, EUR UROL, V62, P324, DOI 10.1016/j.eururo.2012.04.048eng
hcfmusp.relation.referenceLEVIN HS, 1979, HUM PATHOL, V10, P569, DOI 10.1016/S0046-8177(79)80100-8eng
hcfmusp.relation.referenceLupold S, 2013, EVOLUTION, V67, P3052, DOI 10.1111/evo.12132eng
hcfmusp.relation.referenceMarmar JL, 2005, HUM REPROD, V20, P2279, DOI 10.1093/humrep/dei027eng
hcfmusp.relation.referenceMARMAR JL, 1994, J UROLOGY, V152, P1127, DOI 10.1016/S0022-5347(17)32521-1eng
hcfmusp.relation.referenceMasson P, 2014, UROL CLIN N AM, V41, P129, DOI 10.1016/j.ucl.2013.08.001eng
hcfmusp.relation.referenceMcIntyre M, 2012, CURR OPIN UROL, V22, P517, DOI 10.1097/MOU.0b013e328358e191eng
hcfmusp.relation.referenceMcLachlan RI, 2007, HUM REPROD, V22, P2, DOI 10.1093/humrep/del279eng
hcfmusp.relation.referenceNaughton CK, 2001, HUM REPROD UPDATE, V7, P473, DOI 10.1093/humupd/7.5.473eng
hcfmusp.relation.referenceOrganization WH, 2010, WHO LAB MAN EX PROCeng
hcfmusp.relation.referencePasqualotto FF, 2005, J ASSIST REPROD GEN, V22, P227, DOI 10.1007/s10815-005-4926-2eng
hcfmusp.relation.referencePINTO KJ, 1994, J UROLOGY, V152, P788, DOI 10.1016/S0022-5347(17)32710-6eng
hcfmusp.relation.referencePractice Comm Amer Soc Reprod Med, 2014, FERTIL STERIL, V102, P1556, DOI 10.1016/j.fertnstert.2014.10.007eng
hcfmusp.relation.referencePrader A, 1966, Triangle, V7, P240eng
hcfmusp.relation.referenceSchlegel PN, 1997, HUM REPROD, V12, P1688, DOI 10.1093/humrep/12.8.1688eng
hcfmusp.relation.referenceSeo JT, 2010, FERTIL STERIL, V93, P1907, DOI 10.1016/j.fertnstert.2008.12.118eng
hcfmusp.relation.referenceShiraishi K, 2012, INT J UROL, V19, P538, DOI 10.1111/j.1442-2042.2012.02982.xeng
hcfmusp.relation.referenceSILBER SJ, 1981, FERTIL STERIL, V36, P480eng
hcfmusp.relation.referenceSKAKKEBAEK NE, 1973, J REPROD FERTIL, V32, P391eng
hcfmusp.relation.referenceSun XL, 2018, INT UROL NEPHROL, V50, P205, DOI 10.1007/s11255-017-1749-xeng
hcfmusp.relation.referenceThoma ME, 2013, FERTIL STERIL, V99, P1324, DOI 10.1016/j.fertnstert.2012.11.037eng
hcfmusp.relation.referenceUygur MC, 1999, J REPROD MED, V44, P445eng
hcfmusp.relation.referenceZhu SM, 2017, MOL MED REP, V16, P5471, DOI 10.3892/mmr.2017.7253eng
hcfmusp.relation.referenceZini A, 1997, FERTIL STERIL, V68, P671, DOI 10.1016/S0015-0282(97)00311-7eng
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