Is age an independent factor for prostate cancer? A paired analysis
Citações na Scopus
5
Tipo de produção
article
Data de publicação
2017
Título da Revista
ISSN da Revista
Título do Volume
Editora
S. KARGER AG
Autores
GUARIERO, M. E. S.
CAMPOS, O. D. De
Citação
CURRENT UROLOGY, v.9, n.4, p.183-187, 2017
Resumo
Introduction: Prostate cancer is the most prevalent malignant neoplasia among men worldwide. Several prognostic factors, including Gleason's score, the measurement of serum prostate-specific antigen (PSA) and the evaluation of the percentage of fragments affected by cancer on prostate biopsy, have already been established. Age alone, however, has yet to be studied as a prognostic factor independently from other known factors. The aim of the present study was to compare the characteristics and the evolution of prostate cancer in different age groups using a paired analysis for patients with equivalent known prognostic factors. In addition, we aimed to determine the true impact of age on the prognosis of prostate cancer. Material and Methods: The data from 2,283 patients subjected to radical retropubic prostatectomy between 1998 and 2009 were reviewed. The patients were divided into three age groups: < 55 years old, between 56 and 65 and > 65 years old. Each patient was matched to another patient in the other groups who had the same PSA range (< 4.0, between 4.0 and 10.0 and > 10), Gleason score on the surgical specimen and prognostic range of positive fragments in the prostate biopsy (< 33%, between 34 and 50% and > 50%). After pairing, each group consisted of 215 patients, who were compared using the biochemical recurrence of the disease (PSA > 0.2), the interval for biochemical relapse, extra-capsular invasion and invasion of the seminal vesicles or the lymph nodes. RESULTS. No significant difference was observed between the groups regarding the frequency of relapses, interval of relapse, extra-capsular invasion and invasion of the seminal vesicles or lymph nodes. Discussion: None of the studied factors were affected by the age of the patients. Therefore, patients of different ages had tumors with similar characteristics and behaviors. Conclusion: When assessed separately, without the effects of the main prognostic factors, age does not appear to be an independent prognostic factor for prostate cancer. © 2015 S. Karger AG, Basel.
Palavras-chave
Age, Prognosis, Prostate cancer
Referências
- Almeida, S.M., Queiroz-Telles, F., Hag, T., Cel, R., Werneck, L.C., Central nervous system paracoccidioidomycosis: Clinical features and laboratorial findings (2004) J Infect, 48, pp. 193-198
- Mlv, C., Cao, C., Piekala, C., Jfa, N., Alb, P., Neuroparacoccidioidomycosis simulating cerebral metastasis: Case report and literature review (2012) J Bras Neurocirurg, 23, pp. 226-233
- Elias, J., Jr., Dos Santos, A.C., Carlotti, C.G., Colli, B.O., Canheu, A., Matias, C., Central nervous system paracoccidioidomycosis: Diagnosis and treatment (2005) Surg Neurol, 63, pp. 13-21
- Faria, A.V., Dabus, G.C., Zanardi, V.A., Cendes, F., Proton magnetic resonance spectroscopy and magnetic resonance imaging findings in a patient with central nervous system paracoccidioidomycosis (2004) J Neuroimaging, 14, pp. 377-379
- Lambertucci, J.R., Lana-Peixoto, M.A., Pitella, J.E.H., Paracoccidioidomycosis of the central nervous system (2001) Rev Soc Bras Med Trop, 34, pp. 395-396
- Magalhaes, A.C., Caramelli, P., Silva, E., Bacheschi, L.A., Lo, L.S., Menezes, J.R., Magnetic resonance imaging in intracranial paracoccidioidomycosis (1993) J Neuroimaging, 3, pp. 216-219
- Paniago, A.M., De Oliveira, P.A., Aguiar, E.S., Aguiar, J.I., Da Cunha, R.V., Leme, L.M., Neuroparacoccidioidomycosis: Analysis of 13 cases observed in an endemic area in Brazil (1989) Arq Neuropsiquiatr, 47, pp. 224-229
- Vsp, P., Vilela, M.C., Erp, P., Teixeira, A.L., Paracoccidioidomycosis compromising the central nervous system: A systematic review of the literature (2009) Rev Soc Bras Med Trop, 42, pp. 691-697
- Pedroso, V.S.P., (2009) Experimental Studies and Clinical Prospects of Paracoccidioidomycosis, , [Dissertation]. Belo Horizonte: Universidade Federal de. Minas Gerais;
- Reis, F., Collier, P.P., Souza, T.F., Lopes, G.P., Bronzatto, E., Silva Junior, N.A., Pereira, R.M., Appenzeller, S., Neuroparacoccidioidomycosis (NPCM): Magnetic Resonance Imaging (MRI) findings (2013) Mycopathologia, 175, pp. 181-186
- Rodacki, M.A., De Toni, G., Borba, L.A., Oliveira, G.G., Paracoccidioidomycosis of the central nervous system: CT findings (1995) Neuroradiology, 37, pp. 636-641
- Shikanai-Yasuda, M.A., Telles Filho, F.Q., Mendes, R.P., Colombo, A.L., Moretti, M.L., Consensus in paracoccidioidomycosis (2006) Rev Soc Bras Med Trop, 39, pp. 297-310