Genotypic distribution of HHV-8 in AIDS individuals without and with Kaposi sarcoma Is genotype B associated with better prognosis of AIDS-KS?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorTOZETTO-MENDOZA, Tania Regina
dc.contributor.authorIBRAHIM, Karim Yaqub
dc.contributor.authorTATENO, Adriana Fumie
dc.contributor.authorOLIVEIRA, Cristiane Mendes de
dc.contributor.authorSUMITA, Laura Massami
dc.contributor.authorSANCHEZ, Maria Carmem Arroyo
dc.contributor.authorLUNA, Expedito Jose
dc.contributor.authorPIERROTTI, Ligia Camara
dc.contributor.authorDREXLER, Jan Felix
dc.contributor.authorBRAZ-SILVA, Paulo Henrique
dc.contributor.authorPANNUTI, Claudio Sergio
dc.contributor.authorROMANO, Camila Malta
dc.date.accessioned2017-02-16T12:57:23Z
dc.date.available2017-02-16T12:57:23Z
dc.date.issued2016
dc.description.abstractAIDS-associated Kaposi's sarcoma (AIDS-KS) caused by human herpes virus 8 (HHV-8) is the most severe and resistant form of KS tumor. Our aim was to verify whether there is an association between HHV-8 variability and development of AIDS-KS in Brazil by comparing the HHV-8 variability between individuals without and with KS. Saliva samples and blood, when available, were analyzed by PCR techniques for detection of the fragments of ORF K1 of HHV-8, which were then genotyped and analyzed regarding the genetic variability. Our study described 106 positive cases for HHV-8 in the saliva from 751 AIDS patients without previous KS. In addition, we performed a phylogenetic analysis of HHV-8 in 34 of the 106 AIDS patients without KS and in 33 of the 37 patients with active KS. The distribution of HHV-8 genotypes A, B, C, and F in AIDS individuals was indistinguishable by comparing non-KS and KS groups, as well as regarding ethnicity. Considering the KS group, genotype B was associated with better prognosis of KS tumor. Interestingly. we found a particular profile of diversity within Glade C and 2 recombinant patterns of HHV-8 in the saliva of AIDS individuals without KS. We emphasize the need to achieve standard genotyping protocol for ORF K1 amplification, thus allowing for substantial detection of HHV-8 variants. Our findings can shed light on the role of HHV-8 variability in the pathogenesis of AIDS-KS.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP (State of Sao Paulo Research Support Foundation)
dc.identifier.citationMEDICINE, v.95, n.48, article ID e5291, 8p, 2016
dc.identifier.doi10.1097/MD.0000000000005291
dc.identifier.eissn1536-5964
dc.identifier.issn0025-7974
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/18153
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINS
dc.relation.ispartofMedicine
dc.rightsopenAccess
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINS
dc.subjectAIDS-KS
dc.subjectgenotype
dc.subjectHHV-8
dc.subjectORF K1
dc.subjectsaliva
dc.subject.otherherpesvirus type 8
dc.subject.othermultiple sequence alignment
dc.subject.otherlow viral load
dc.subject.othermolecular epidemiology
dc.subject.otherhuman-herpesvirus-8 infection
dc.subject.othergenetic-variability
dc.subject.otherbrazilian amazon
dc.subject.otherk1 protein
dc.subject.othersao-paulo
dc.subject.othersubtypes
dc.subject.wosMedicine, General & Internal
dc.titleGenotypic distribution of HHV-8 in AIDS individuals without and with Kaposi sarcoma Is genotype B associated with better prognosis of AIDS-KS?
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryAlemanha
hcfmusp.affiliation.countryisode
hcfmusp.author.externalDREXLER, Jan Felix:Univ Bonn, Inst Virol, Med Ctr, German Ctr Infect Res DZIF,Partner Site Bonn Colo, Bonn, Germany
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcTANIA REGINA TOZETTO MENDOZA
hcfmusp.contributor.author-fmusphcKARIM YAQUB IBRAHIM
hcfmusp.contributor.author-fmusphcADRIANA FUMIE TATENO
hcfmusp.contributor.author-fmusphcCRISTINA MENDES DE OLIVEIRA
hcfmusp.contributor.author-fmusphcLAURA MASAMI SUMITA
hcfmusp.contributor.author-fmusphcMARIA CARMEN ARROYO SANCHEZ
hcfmusp.contributor.author-fmusphcEXPEDITO JOSE DE ALBUQUERQUE LUNA
hcfmusp.contributor.author-fmusphcLIGIA CAMERA PIERROTTI
hcfmusp.contributor.author-fmusphcPAULO HENRIQUE BRAZ DA SILVA
hcfmusp.contributor.author-fmusphcCLAUDIO SERGIO PANNUTI
hcfmusp.contributor.author-fmusphcCAMILA MALTA ROMANO
hcfmusp.description.articlenumbere5291
hcfmusp.description.issue48
hcfmusp.description.volume95
hcfmusp.origemWOS
hcfmusp.origem.pubmed27902590
hcfmusp.origem.scopus2-s2.0-85007477405
hcfmusp.origem.wosWOS:000389591500009
hcfmusp.publisher.cityPHILADELPHIA
hcfmusp.publisher.countryUSA
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