Cytokine Levels and Human Herpesviruses in Saliva from Clinical Periodontal Healthy Subjects with Peri-Implantitis: A Case-Control Study

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art_MARQUES FILHO_Cytokine_Levels_and_Human_Herpesviruses_in_Saliva_from_2018.PDF (1.45 MB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2018
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
HINDAWI LTD
Autores
MARQUES FILHO, Jaime S.
JR, Jorge Gobara
SALOMAO, Gustavo Vargas da Silva
SHIBLI, Jamil A.
VIANA, Renato G.
SCHWARTZ FILHO, Humberto O.
PALLOS, Debora
Citação
MEDIATORS OF INFLAMMATION, article ID 6020625, 7p, 2018
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
This study evaluated the presence of cytokines (IL-1 beta, IL-2, IL-4, IL-6, MCP-1, MIP-1 alpha , MIP-1 beta, and TNF-alpha) and human herpesvirus (HSVI, HSV2, EBV, CMV, VZV, HHV6, HHV7, and HHV8) in saliva samples taken from subjects with and without peri-implantitis. Forty-two periodontally healthy subjects were divided according to peri-implant condition: healthy and peri-implantitis groups. The clinical parameters as probing depth, clinical attachment level, plaque index, gingival bleeding, bleeding on probing, and suppuration were evaluated. For cytokine detection, multiplex analysis was performed, and PCR assay was used to identify herpesviruses. No significant differences were found in cytokine levels between groups (p > 0.05). The presence of herpesvirus was 1.97-fold higher in patients with peri-implantitis (odds ratio, CI 0.52-7.49). The association of the presence or absence of herpesvirus with the salivary markers was statistically significant for MIP-1 beta (p = 0.0087) and TNF-alpha (p = 0.0437) only in the peri-implantitis group. The presence of herpesviruses in patients with peri-implantitis suggests the development of a proinflammatory environment, which is characterized by increased expression of MIP-1 beta and TNF-alpha in saliva.
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URI
https://observatorio.fm.usp.br/handle/OPI/28137
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Coleções
Artigos e Materiais de Revistas Científicas - FM/MIP
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/52