Gender and age influence in daytime and nighttime seizure occurrence in epilepsy associated with mesial temporal sclerosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorPASSARELLI, Valmir
dc.contributor.authorCASTRO, Luiz Henrique Martins
dc.date.accessioned2015-12-10T16:44:27Z
dc.date.available2015-12-10T16:44:27Z
dc.date.issued2015
dc.description.abstractObjectives: The aim of this study was to analyze the daytime and nighttime seizure distribution during video-EEG monitoring in patients with epilepsy associated with unilateral mesial temporal sclerosis (MTS) and the role of gender, age, and lesion side on 24-hour seizure distribution. Methods: We studied 167 consecutive adult (age >= 16 years) patients with epilepsy associated with unilateral mesial temporal sclerosis that had three or more recorded seizures during continuous video-EEG monitoring with a minimum recording time period of 24 h. Seizure onset time was classified according to occurrence in six 4-hour periods. Results: Seven hundred thirty-five seizures were evaluated. We observed two higher seizure occurrence periods: 08: 01-12: 00 (p = 0.001) and 16: 01-20: 00 (p = 0.03). Significantly fewer seizures were observed between 0: 01 and 4: 00 (p = 0.01). Nonuniform seizure distribution was noted in women (p < 0.0001), in young patients (less than 45 years of age) (p < 0.0001), and in both patients with left (p = 0.03) and patients with right mesial temporal sclerosis (p = 0.008). Men presented uniform seizure occurrence distribution (p = 0.15). Women had fewer seizures than expected and fewer seizures than men between 0: 01-04: 00 (p < 0.0001 and p = 0.0015, respectively) and 04: 01-08: 00 (p = 0.01 and p = 0.03, respectively). Young patients (age b 45 years) had two seizure occurrence peaks, 08: 01-12: 00 (p = 0.016) and 16: 01-20: 00 (p = 0.004). Middle-aged/old patients (>= 45 years) had only one seizure occurrence peak, 08: 01-12: 00 (p = 0.012). Young patients had more seizures than middle-aged/old patients between 16: 01-20: 00 (p = 0.04). No differences were noted between left and right MTS. Significance: We observed two seizure occurrence peaks: morning and late afternoon/evening. We encountered variations in daytime and nighttime seizure distribution according to gender and age, but not according to side of MTS. Future studies are needed to confirm these findings and to unravel the neurobiological substrate underlying daytime and nighttime variations of seizure occurrence in different age groups and between genders.
dc.description.indexMEDLINE
dc.identifier.citationEPILEPSY & BEHAVIOR, v.50, p.14-17, 2015
dc.identifier.doi10.1016/j.yebeh.2015.05.028
dc.identifier.eissn1525-5069
dc.identifier.issn1525-5050
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/12409
dc.language.isoeng
dc.publisherACADEMIC PRESS INC ELSEVIER SCIENCE
dc.relation.ispartofEpilepsy & Behavior
dc.rightsrestrictedAccess
dc.rights.holderCopyright ACADEMIC PRESS INC ELSEVIER SCIENCE
dc.subjectGender
dc.subjectAge
dc.subjectMesial temporal lobe epilepsy
dc.subjectSeizures
dc.subjectCircadian
dc.subject.otheranticonvulsant properties
dc.subject.othersex-differences
dc.subject.othermelatonin
dc.subject.otherreappraisal
dc.subject.otherrhythm
dc.subject.wosBehavioral Sciences
dc.subject.wosClinical Neurology
dc.subject.wosPsychiatry
dc.titleGender and age influence in daytime and nighttime seizure occurrence in epilepsy associated with mesial temporal sclerosis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcVALMIR DE OLIVEIRA PASSARELLI
hcfmusp.contributor.author-fmusphcLUIZ HENRIQUE MARTINS CASTRO
hcfmusp.description.beginpage14
hcfmusp.description.endpage17
hcfmusp.description.volume50
hcfmusp.origemWOS
hcfmusp.origem.pubmed26093513
hcfmusp.origem.scopus2-s2.0-84934918289
hcfmusp.origem.wosWOS:000361186300003
hcfmusp.publisher.citySAN DIEGO
hcfmusp.publisher.countryUSA
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