Predicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factors

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorAMARAL-CARVALHO, Viviane
dc.contributor.authorLIMA-SILVA, Thais Bento
dc.contributor.authorMARIANO, Luciano Inacio
dc.contributor.authorSOUZA, Leonardo Cruz de
dc.contributor.authorGUIMARAES, Henrique Cerqueira
dc.contributor.authorBAHIA, Valeria Santoro
dc.contributor.authorNITRINI, Ricardo
dc.contributor.authorBARBOSA, Maira Tonidandel
dc.contributor.authorYASSUDA, Monica Sanches
dc.contributor.authorCARAMELLI, Paulo
dc.date.accessioned2023-12-15T18:54:06Z
dc.date.available2023-12-15T18:54:06Z
dc.date.issued2023
dc.description.abstractBackground: Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) are important causes of dementia with challenging differential diagnoses in many cases. Addenbrooke's Cognitive Examination-Revised (ACE-R) is a cognitive battery that may be useful to differentiate the two disorders.Objective: The objectibe of this study is to investigate the value of the ACE-R combined with sociodemographic factors in the differential diagnosis between AD and bvFTD.Methods The ACE-R was administered to 102 patients with mild dementia due to probable AD, 37 with mild bvFTD, and 135 controls. Performances of patients and controls were analyzed by logistic regression and by ROC curves to refine the diagnostic accuracy of the ACE-R in AD and bvFTD.Results: The ACE-R subscores Attention and Orientation, Fluency, and Memory, in combination with schooling differentiated AD from controls with an area under the ROC curve (AUC) of 0.936 (86% sensitivity and 87% specificity). The ACE-R subscores Attention and Orientation, Fluency, and Language, in combination with sex (male), age, and schooling, discriminated bvFTD from controls with an AUC of 0.908 (81% sensitivity and 95% specificity). In the differentiation between AD and bvFTD, the ACE-R subscores Attention and Orientation, Fluency, and Language, together with age, displayed an AUC of 0.865 (78% sensitivity and 85% specificity).Conclusion: The combination of ACE-R scores with sociodemographic data allowed good differentiation between AD and bvFTD in the study sample.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipDeclared none.
dc.identifier.citationCURRENT ALZHEIMER RESEARCH, v.20, n.5, p.341-349, 2023
dc.identifier.doi10.2174/1567205020666230816160700
dc.identifier.eissn1875-5828
dc.identifier.issn1567-2050
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57461
dc.language.isoeng
dc.publisherBENTHAM SCIENCE PUBL LTDeng
dc.relation.ispartofCurrent Alzheimer Research
dc.rightsrestrictedAccesseng
dc.rights.holderCopyright BENTHAM SCIENCE PUBL LTDeng
dc.subjectCognitioneng
dc.subjectdementiaeng
dc.subjectfrontotemporal dementiaeng
dc.subjectalzheimer's diseaseeng
dc.subjectagingeng
dc.subjectneuropsychological testseng
dc.subject.otherace-reng
dc.subject.otherneuropsychiatric-inventoryeng
dc.subject.otherimpairmenteng
dc.subject.otherdiagnosiseng
dc.subject.otheraccuracyeng
dc.subject.othercriteriaeng
dc.subject.otherversioneng
dc.subject.wosClinical Neurologyeng
dc.subject.wosNeuroscienceseng
dc.titlePredicting Dementia Due to Alzheimer's Disease and Behavioral Variant Frontotemporal Dementia Using Algorithms with the Addenbrooke's Cognitive Examination-Revised Subscores Combined with Sociodemographic Factorseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalMARIANO, Luciano Inacio:Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Behav & Cognit Neurol Res Grp, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais UFMG, Programa Posgrad Neurociencias, Belo Horizonte, MG, Brazil
hcfmusp.author.externalSOUZA, Leonardo Cruz de:Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Behav & Cognit Neurol Res Grp, Belo Horizonte, MG, Brazil; Univ Fed Minas Gerais UFMG, Programa Posgrad Neurociencias, Belo Horizonte, MG, Brazil
hcfmusp.author.externalGUIMARAES, Henrique Cerqueira:Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Behav & Cognit Neurol Res Grp, Belo Horizonte, MG, Brazil
hcfmusp.author.externalBAHIA, Valeria Santoro:Univ Sao Paulo, Dept Neurol, Programa Posgrad Neurol, Fac Med, Sao Paulo, SP, Brazil
hcfmusp.author.externalBARBOSA, Maira Tonidandel:Univ Fed Minas Gerais, Fac Med, Dept Clin Med, Behav & Cognit Neurol Res Grp, Belo Horizonte, MG, Brazil; Fac Ciencias Med Minas Gerais, Belo Horizonte, MG, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcVIVIANE AMARAL CARVALHO
hcfmusp.contributor.author-fmusphcTHAIS BENTO LIMA DA SILVA
hcfmusp.contributor.author-fmusphcRICARDO NITRINI
hcfmusp.contributor.author-fmusphcMONICA SANCHES YASSUDA
hcfmusp.contributor.author-fmusphcPAULO CARAMELLI
hcfmusp.description.beginpage341
hcfmusp.description.endpage349
hcfmusp.description.issue5
hcfmusp.description.volume20
hcfmusp.origemWOS
hcfmusp.origem.pubmed37587822
hcfmusp.origem.scopus2-s2.0-85175245171
hcfmusp.origem.wosWOS:001092090800003
hcfmusp.publisher.citySHARJAHeng
hcfmusp.publisher.countryU ARAB EMIRATESeng
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hcfmusp.scopus.lastupdate2024-05-17
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