DAX1 Overexpression in Pediatric Adrenocortical Tumors: A Synergic Role with SF1 in Tumorigenesis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSOUSA, G. R. V. de
dc.contributor.authorSOARES, I. C.
dc.contributor.authorFARIA, A. M.
dc.contributor.authorDOMINGUES, V. B.
dc.contributor.authorWAKAMATSU, A.
dc.contributor.authorLERARIO, A. M.
dc.contributor.authorALVES, V. A. F.
dc.contributor.authorZERBINI, M. C. N.
dc.contributor.authorMENDONCA, B. B.
dc.contributor.authorFRAGOSO, M. C. B. V.
dc.contributor.authorLATRONICO, A. C.
dc.contributor.authorALMEIDA, M. Q.
dc.date.accessioned2015-10-26T16:32:32Z
dc.date.available2015-10-26T16:32:32Z
dc.date.issued2015
dc.description.abstractDAX1 transcription factor is a key determinant of adrenogonadal development, acting as a repressor of SF1 targets in steroidogenesis. It was recently demonstrated that DAX1 regulates pluripotency and differentiation in murine embryonic stem cells. In this study, we investigated DAX1 expression in adrenocortical tumors (ACTs) and correlated it with SF1 expression and clinical parameters. DAX1 and SF1 protein expression were assessed in 104 ACTs from 34 children (25 clinically benign and 9 malignant) and 70 adults (40 adenomas and 30 carcinomas). DAX1 gene expression was studied in 49 ACTs by quantitative real-time PCR. A strong DAX1 protein expression was demonstrated in 74% (25 out of 34) and 24% (17 out of 70) of pediatric and adult ACTs, respectively ((2)=10.1, p=0.002). In the pediatric group, ACTs with a strong DAX1 expression were diagnosed at earlier ages than ACTs with weak expression [median 1.2 (range, 0.5-4.5) vs. 2.2 (0.9-9.4), p=0.038]. DAX1 expression was not associated with functional status in ACTs. Interestingly, a positive correlation was observed between DAX1 and SF1 protein expression in both pediatric and adult ACTs (r=0.55 for each group separately; p<0.0001). In addition, DAX1 gene expression was significantly correlated with SF1 gene expression (p<0.0001, r=0.54). In conclusion, DAX1 strong protein expression was more frequent in pediatric than in adult ACTs. Additionally, DAX1 and SF1 expression positively correlated in ACTs, suggesting that these transcription factors might cooperate in adrenocortical tumorigenesis.
dc.description.indexMEDLINE
dc.description.sponsorshipFAPESP [2011/09092-0, 2012/21272-6, 06/00244-3]
dc.description.sponsorshipCNPq [470428/2013-9, 305743/2011-2, 470631/2012-0, 302825/2011-8]
dc.identifier.citationHORMONE AND METABOLIC RESEARCH, v.47, n.9, p.656-661, 2015
dc.identifier.doi10.1055/s-0034-1398560
dc.identifier.eissn1439-4286
dc.identifier.issn0018-5043
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/11832
dc.language.isoeng
dc.publisherGEORG THIEME VERLAG KG
dc.relation.ispartofHormone and Metabolic Research
dc.rightsrestrictedAccess
dc.rights.holderCopyright GEORG THIEME VERLAG KG
dc.subjectDAX1
dc.subjectSF1
dc.subjectexpression
dc.subjectadrenocortical tumors
dc.subject.otheradrenal hypoplasia congenita
dc.subject.othersteroidogenic factor-1
dc.subject.othercell differentiation
dc.subject.otherexpression profiles
dc.subject.otherprognostic value
dc.subject.othersex reversal
dc.subject.othergene
dc.subject.otherreceptor
dc.subject.othercancer
dc.subject.otherclassification
dc.subject.wosEndocrinology & Metabolism
dc.titleDAX1 Overexpression in Pediatric Adrenocortical Tumors: A Synergic Role with SF1 in Tumorigenesis
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSOARES, I. C.:Hosp Canc Barretos, Ro, Brazil
hcfmusp.author.externalDOMINGUES, V. B.:Univ Sao Paulo, Hosp Clin, Div Anat Patol, Lab Patol Hepat LIM14,Fac Med, BR-05403900 Sao Paulo, SP, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcGABRIELA RESENDE VIEIRA DE SOUSA
hcfmusp.contributor.author-fmusphcANDRE MURAD FARIA
hcfmusp.contributor.author-fmusphcALDA WAKAMATSU
hcfmusp.contributor.author-fmusphcANTONIO MARCONDES LERARIO
hcfmusp.contributor.author-fmusphcVENANCIO AVANCINI FERREIRA ALVES
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA NOGUEIRA ZERBINI
hcfmusp.contributor.author-fmusphcBERENICE BILHARINHO DE MENDONCA
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.contributor.author-fmusphcANA CLAUDIA LATRONICO XAVIER
hcfmusp.contributor.author-fmusphcMADSON QUEIROZ DE ALMEIDA
hcfmusp.description.beginpage656
hcfmusp.description.endpage661
hcfmusp.description.issue9
hcfmusp.description.volume47
hcfmusp.origemWOS
hcfmusp.origem.pubmed25985323
hcfmusp.origem.scopus2-s2.0-84938956743
hcfmusp.origem.wosWOS:000359597300006
hcfmusp.publisher.citySTUTTGART
hcfmusp.publisher.countryGERMANY
hcfmusp.relation.referenceAchermann JC, 1999, NAT GENET, V22, P125
hcfmusp.relation.referenceAlmeida MQ, 2007, HORM METAB RES, V39, P461, DOI 10.1055/s-2007-981476
hcfmusp.relation.referenceAlmeida MQ, 2008, J CLIN ENDOCR METAB, V93, P3524, DOI 10.1210/jc.2008-0065
hcfmusp.relation.referenceAlmeida MQ, 2010, J CLIN ENDOCR METAB, V95, P1458, DOI 10.1210/jc.2009-2040
hcfmusp.relation.referenceBassett MH, 2005, J CLIN ENDOCR METAB, V90, P5446, DOI 10.1210/jc.2005-0836
hcfmusp.relation.referenceBURRIS TP, 1995, BIOCHEM BIOPH RES CO, V214, P576, DOI 10.1006/bbrc.1995.2324
hcfmusp.relation.referenceConde I, 2004, BREAST CANCER RES, V6, pR140, DOI 10.1186/bcr766
hcfmusp.relation.referenceFaria AM, 2012, MOL CELL ENDOCRINOL, V351, P52, DOI 10.1016/j.mce.2011.09.040
hcfmusp.relation.referenceFassnacht M, 2009, CANCER, V115, P243, DOI 10.1002/cncr.24030
hcfmusp.relation.referenceFigueiredo BC, 2005, J CLIN ENDOCR METAB, V90, P615, DOI 10.1210/jc.2004-0942
hcfmusp.relation.referenceGarcia-Aragoncillo E, 2008, ONCOGENE, V27, P6034, DOI 10.1038/onc.2008.203
hcfmusp.relation.referenceGiordano TJ, 2009, CLIN CANCER RES, V15, P668, DOI 10.1158/1078-0432.CCR-08-1067
hcfmusp.relation.referenceGlover CH, 2006, PLOS COMPUT BIOL, V2, P1463, DOI 10.1371/journal.pcbi.0020158
hcfmusp.relation.referenceHelguero LA, 2006, ENDOCRINOLOGY, V147, P3249, DOI 10.1210/en.2005-1651
hcfmusp.relation.referenceKhalfallah O, 2009, STEM CELLS, V27, P1529, DOI 10.1002/stem.78
hcfmusp.relation.referenceKinsey M, 2009, CANCER RES, V69, P9047, DOI 10.1158/0008-5472.CAN-09-1540
hcfmusp.relation.referenceLalli E, EXPERT OPIN THER TAR, V14, P169
hcfmusp.relation.referenceLalli E, 1998, ENDOCRINOLOGY, V139, P4237, DOI 10.1210/en.139.10.4237
hcfmusp.relation.referenceLalli E, 2014, CELL DEATH DIS, V5, DOI 10.1038/cddis.2013.446
hcfmusp.relation.referenceLatronico AC, 1997, J CLIN ENDOCR METAB, V82, P1317, DOI 10.1210/jc.82.5.1317
hcfmusp.relation.referenceMizusaki H, 2003, MOL ENDOCRINOL, V17, P507, DOI 10.1210/me.2002-0362
hcfmusp.relation.referenceMUSCATELLI F, 1994, NATURE, V372, P672, DOI 10.1038/372672a0
hcfmusp.relation.referenceNiakan KK, 2006, MOL GENET METAB, V88, P261, DOI 10.1016/j.ymgme.2005.12.010
hcfmusp.relation.referenceOda T, 2009, AM J PATHOL, V175, P1235, DOI 10.2353/ajpath.2009.090010
hcfmusp.relation.referenceOlaussen KA, 2006, NEW ENGL J MED, V355, P983, DOI 10.1056/NEJMoa060570
hcfmusp.relation.referencePark SY, 2005, DEVELOPMENT, V132, P2415, DOI 10.1242/dev.01826
hcfmusp.relation.referenceReincke M, 1998, J CLIN ENDOCR METAB, V83, P2597, DOI 10.1210/jc.83.7.2597
hcfmusp.relation.referenceSbiera S, 2010, J CLIN ENDOCR METAB, V95, pE161, DOI 10.1210/jc.2010-0653
hcfmusp.relation.referenceShibata H, 2001, MOL GENET METAB, V74, P206, DOI 10.1006/mgme.2001.3231
hcfmusp.relation.referenceTissier F, 2005, CANCER RES, V65, P7622, DOI 10.1158/0008-5472.CAN-05-0593
hcfmusp.relation.referenceVilain E, 1997, BIOCHEM MOL MED, V61, P1, DOI 10.1006/bmme.1997.2601
hcfmusp.relation.referenceWieneke JA, 2003, AM J SURG PATHOL, V27, P867, DOI 10.1097/00000478-200307000-00001
hcfmusp.relation.referenceZANARIA E, 1994, NATURE, V372, P635, DOI 10.1038/372635a0
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