CORRELATION BETWEEN THE EXPRESSION OF VEGF AND SURVIVAL IN OSTEOSARCOMA

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorBAPTISTA, Andre Mathias
dc.contributor.authorCAMARGO, Andre Ferrari de Franca
dc.contributor.authorFILIPPI, Renee Zon
dc.contributor.authorOLIVEIRA, Claudia Regina Gomes Cardim Mendes de
dc.contributor.authorAZEVEDO NETO, Raymundo Soares de
dc.contributor.authorCAMARGO, Olavo Pires de
dc.date.accessioned2015-07-01T20:34:04Z
dc.date.available2015-07-01T20:34:04Z
dc.date.issued2014
dc.description.abstractObjective: To present a series of 50 consecutive patients with non-metastatic extremity osteosarcoma, and attempt to correlate expression of the vascular endothelial growth factor (VEGF) protein in biopsy tissue to their prognosis regarding overall survival, disease-free survival and local recurrence. Methods: Fifty cases of non-metastatic osteosarcoma of the extremities treated between 1986 and 2006 at Instituto de Ortopedia e Traumatologia da Universidade de Sao Paulo, Sao Paulo, Brasil, were evaluated regarding expression of the VEGF protein. There were 19 females and 31 males. The mean age was 16 years old (range 5-28 years old) and the mean follow-up was 60.6 months (range 25-167 months). The variables studied were age, gender, anatomic location, type of surgery, surgical margins, tumor size, post chemotherapy necrosis, local recurrence, pulmonary metastasis and death. Results: Thirty-six patients showed VEGF expression on 30% or less cells (low), and the remaining 14 cases had VEGF expression above 30% (high). Among the 36 patients with low VEGF expression, nine developed pulmonary metastasis and four died (11.1%). Among the 14 patients with high VEGF expression, six developed pulmonary metastasis and three died (21.4%). Conclusion: There was no statistically significant correlation between the expression of VEGF and any of the variables studied.
dc.description.indexWoS
dc.identifier.citationACTA ORTOPEDICA BRASILEIRA, v.22, n.5, p.250-255, 2014
dc.identifier.doi10.1590/1413-78522014220500978
dc.identifier.eissn1809-4406
dc.identifier.issn1413-7852
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/9489
dc.language.isoeng
dc.publisherATHA COMUNICACAO & EDITORA
dc.relation.ispartofActa Ortopedica Brasileira
dc.rightsopenAccess
dc.rights.holderCopyright ATHA COMUNICACAO & EDITORA
dc.subjectOsteosarcoma
dc.subjectPrognosis
dc.subjectNeovascularization
dc.subjectpathologic
dc.subject.otherendothelial growth-factor
dc.subject.otherprognostic-significance
dc.subject.otherosteogenic-sarcoma
dc.subject.otherpoor-prognosis
dc.subject.otherchemotherapy
dc.subject.othermetastasis
dc.subject.othermetaanalysis
dc.subject.othercxcr4
dc.subject.wosOrthopedics
dc.titleCORRELATION BETWEEN THE EXPRESSION OF VEGF AND SURVIVAL IN OSTEOSARCOMA
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus16
hcfmusp.contributor.author-fmusphcANDRE MATHIAS BAPTISTA
hcfmusp.contributor.author-fmusphcANDRE FERRARI DE FRANCA CAMARGO
hcfmusp.contributor.author-fmusphcRENEE ZON FILIPPI
hcfmusp.contributor.author-fmusphcCLAUDIA REGINA GOMES CARDIM MENDES DE OLIVEIRA
hcfmusp.contributor.author-fmusphcRAYMUNDO SOARES DE AZEVEDO NETO
hcfmusp.contributor.author-fmusphcOLAVO PIRES DE CAMARGO
hcfmusp.description.beginpage250
hcfmusp.description.endpage255
hcfmusp.description.issue5
hcfmusp.description.volume22
hcfmusp.origemWOS
hcfmusp.origem.pubmed25328432
hcfmusp.origem.scieloSCIELO:S1413-78522014000500250
hcfmusp.origem.scopus2-s2.0-84907816561
hcfmusp.origem.wosWOS:000347410400004
hcfmusp.publisher.citySAO PAULO SP
hcfmusp.publisher.countryBRAZIL
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Artigos e Materiais de Revistas Científicas - FM/MOT
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