Circulating Glial-derived neurotrophic factor is reduced in late-life depression

Imagem de Miniatura
Arquivos
art_DINIZ_Circulating_Glial_derived_neurotrophic_factor_is_reduced_in_2012.PDF (173.94 KB)
Citações na Scopus
60
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PERGAMON-ELSEVIER SCIENCE LTD
Autores
TEIXEIRA, Antonio L.
MIRANDA, Aline S.
Citação
JOURNAL OF PSYCHIATRIC RESEARCH, v.46, n.1, p.135-139, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Background: The Glial Cell-line derived neurotrophic factor (GDNF) is part of the TGF-beta superfamily and is abundantly expressed in the central nervous system. Changes in GDNF homeostasis have been reported in affective disorders. Aim: To assess serum GDNF concentration in elderly subjects with late-life depression, before antidepressant treatment, as compared to healthy elderly controls. Methods: Thirty-four elderly subjects with major depression and 37 age and gender-matched healthy elderly controls were included in this study. Diagnosis of major depression was ascertained by the SCID interview for DSM-IV and the severity of depressive symptoms was assessed by the Hamilton Depression Rating Scale (HDRS-21). Serum GDNF concentration were determined by sandwich ELISA. Results: Patients with major depression showed a significant reduction in GDNF levels as compared to healthy elderly controls (p < 0.001). Also, GDNF level was negatively correlated with HDRS-21 scores (r = -0.343, p = 0.003). Discussion: Our data provide evidence that GDNF may be a state marker of depressive episode in older adults. Changes in the homeostatic control of GDNF production may be a target to development of new antidepressant strategies.
Palavras-chave
GDNF, Late-life depression, Physiopathology, Neurotrophic cascades
URI
https://observatorio.fm.usp.br/handle/OPI/1117
Referências
  1. Airaksinen MS, 2002, NAT REV NEUROSCI, V3, P383, DOI 10.1038/nrn812
  2. Alexopoulos GS, 1997, ARCH GEN PSYCHIAT, V54, P915
  3. Alladi PA, 2010, J CHEM NEUROANAT, V40, P43, DOI 10.1016/j.jchemneu.2010.03.007
  4. Alleva E, 2009, NEUROSCI BIOBEHAV R, V33, P525, DOI 10.1016/j.neubiorev.2008.09.004
  5. American Psychiatric Association, 2000, DIAGN STAT MAN MENT
  6. Barbosa IG, 2011, NEUROSCI LETT, V502, P103, DOI 10.1016/j.neulet.2011.07.031
  7. Brunoni AR, 2008, INT J NEUROPSYCHOPH, V11, P1169, DOI 10.1017/S1461145708009309
  8. Chen ACH, 2001, SYNAPSE, V39, P42, DOI 10.1002/1098-2396(20010101)39:1<42::AID-SYN6>3.0.CO;2-#
  9. Cunningham C, 2009, BIOL PSYCHIAT, V65, P304, DOI 10.1016/j.biopsych.2008.07.024
  10. Dass B, 2006, NEUROBIOL AGING, V27, P857, DOI 10.1016/j.neurobiolaging.2005.04.002
  11. de Sousa RT, 2011, NEUROSCI LETT, V494, P54, DOI 10.1016/j.neulet.2011.02.054
  12. Diniz BS, 2010, J ALZHEIMERS DIS, V22, P1305, DOI 10.3233/JAD-2010-100921
  13. Diniz BS, 2008, REV BRAS PSIQUIATR, V30, P316
  14. Diniz BS, 2011, WORLD J BIOL PSYCHIA, V12, P216, DOI 10.3109/15622975.2010.551408
  15. Diniz BS, 2010, J PSYCHIATR RES, V44, P917, DOI 10.1016/j.jpsychires.2010.02.008
  16. Diniz BS, 2010, AM J GERIAT PSYCHIAT, V18, P172, DOI 10.1097/JGP.0b013e3181c2947f
  17. Diniz BS, 2010, WORLD J BIOL PSYCHIA, V11, P550, DOI 10.3109/15622970903544620
  18. First M.B., 2002, STRUCTURED CLIN INTE
  19. FOLSTEIN MF, 1975, J PSYCHIAT RES, V12, P189, DOI 10.1016/0022-3956(75)90026-6
  20. Forlenza OV, 2010, REV BRAS PSIQUIATR, V32, P216, DOI 10.1590/S1516-44462010005000002
  21. Forlenza OV, 2010, WORLD J BIOL PSYCHIA, V11, P774, DOI 10.3109/15622971003797241
  22. Franceschi C, 2000, ANN NY ACAD SCI, V908, P244
  23. Golan M, 2011, INT J NEUROPSYCHOPH, DOI 10.1017/S1461145710001550
  24. HAMILTON M, 1960, J NEUROL NEUROSUR PS, V23, P56, DOI 10.1136/jnnp.23.1.56
  25. Hisaoka K, 2001, J NEUROCHEM, V79, P25, DOI 10.1046/j.1471-4159.2001.00531.x
  26. Hisaoka K, 2011, J BIOL CHEM, V286, P21118, DOI 10.1074/jbc.M111.224683
  27. Lee TH, 2006, BRAIN RES, V1116, P31, DOI 10.1016/j.brainres.2006.07.117
  28. Leyhe T, 2008, EUR ARCH PSY CLIN N, V258, P124, DOI 10.1007/s00406-007-0764-9
  29. Meltzer CC, 2004, NEUROPSYCHOPHARMACOL, V29, P2258, DOI 10.1038/sj.npp.1300556
  30. Michel TM, 2008, EUR PSYCHIAT, V23, P413, DOI 10.1016/j.eurpsy.2008.06.001
  31. Nunes PV, 2008, INT J GERIATR PSYCH, V23, P1127, DOI 10.1002/gps.2038
  32. Otsuki K, 2008, J PSYCHIATR RES, V42, P1145, DOI 10.1016/j.jpsychires.2008.01.010
  33. Pascual A, 2008, NAT NEUROSCI, V11, P755, DOI 10.1038/nn.2136
  34. Rosa AR, 2006, NEUROSCI LETT, V407, P146, DOI 10.1016/j.neulet.2006.08.026
  35. ROTH M, 1986, BRIT J PSYCHIAT, V149, P698, DOI 10.1192/bjp.149.6.698
  36. Sheline YI, 2004, NEUROPSYCHOPHARMACOL, V29, P2235, DOI 10.1038/sj.npp.1300555
  37. Straten G, 2009, J ALZHEIMERS DIS, V18, P331, DOI 10.3233/JAD-2009-1146
  38. Straten G, 2002, NEUROBIOL DIS, V11, P123, DOI 10.1006/nbdi.2002.0543
  39. Takebayashi M, 2006, INT J NEUROPSYCHOPH, V9, P607, DOI 10.1017/S1461145705006085
  40. Tapia-Arancibia L, 2008, BRAIN RES REV, V59, P201, DOI 10.1016/j.brainresrev.2008.07.007
  41. Teixeira AL, 2010, BIOMARK MED, V4, P871, DOI [10.2217/bmm.10.111, 10.2217/BMM.10.111]
  42. Uchida S, 2011, NEURON, V69, P359, DOI 10.1016/j.neuron.2010.12.023
  43. Wang XQ, 2011, J AFFECT DISORDERS, V132, P418, DOI 10.1016/j.jad.2011.03.043
  44. Yu H, 2008, J CLIN PSYCHIAT, V69, P1104
  45. Zhang XB, 2009, PSYCHIAT RES, V170, P273, DOI 10.1016/j.psychres.2009.01.011
  46. Zhang XB, 2010, J AFFECT DISORDERS, V126, P326, DOI 10.1016/j.jad.2010.03.003
  47. Zhang XB, 2008, PROG NEURO-PSYCHOPH, V32, P886, DOI 10.1016/j.pnpbp.2008.01.004

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - LIM/27