Lp25 membrane protein from pathogenic Leptospira spp. is associated with rhabdomyolysis and oliguric acute kidney injury in a guinea pig model of leptospirosis

Imagem de Miniatura
Arquivos
art_ABREU_Lp25_membrane_protein_from_pathogenic_Leptospira_spp_is_2017.PDF (12.84 MB)
Citações na Scopus
16
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
PUBLIC LIBRARY SCIENCE
Autores
ABREU, Patricia A. E.
MATOS, Larissa do R. B.
GOTTI, Tatiane B.
MONARIS, Denize
VASCONCELLOS, Silvio A.
Citação
PLOS NEGLECTED TROPICAL DISEASES, v.11, n.5, article ID e0005615, 16p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Acute kidney injury (AKI) from leptospirosis is frequently nonoliguric with hypo- or normokalemia. Higher serum potassium levels are observed in non-survivor patients and may have been caused by more severe AKI, metabolic disarrangement, or rhabdomyolysis. An association between the creatine phosphokinase (CPK) level and maximum serum creatinine level has been observed in these patients, which suggests that rhabdomyolysis contributes to severe AKI and hyperkalemia. LipL32 and Lp25 are conserved proteins in pathogenic strains of Leptospira spp., but these proteins have no known function. This study evaluated the effect of these proteins on renal function in guinea pigs. Lp25 is an outer membrane protein that appears responsible for the development of oliguric AKI associated with hyperkalemia induced by rhabdomyolysis (e.g., elevated CPK, uric acid and serum phosphate). This study is the first characterization of a leptospiral outer membrane protein that is associated with severe manifestations of leptospirosis. Therapeutic methods to attenuate this protein and inhibit rhabdomyolysis-induced AKI could protect animals and patients from severe forms of this disease and decrease mortality.
Palavras-chave
URI
https://observatorio.fm.usp.br/handle/OPI/26200
Referências
  1. Abdulkader RCRM, 2008, PEDIATR NEPHROL, V23, P2111, DOI 10.1007/s00467-008-0811-4
  2. Andrade L, 2008, SEMIN NEPHROL, V28, P383, DOI 10.1016/j.semnephrol.2008.04.008
  3. Araujo ER, 2010, VIRCHOWS ARCH, V456, P367, DOI 10.1007/s00428-010-0894-8
  4. Barbosa AS, 2006, INFECT IMMUN, V74, P6356, DOI 10.1128/IAI.00460-06
  5. Barbosa AS, 2010, INFECT IMMUN, V78, P3207, DOI 10.1128/IAI.00279-10
  6. Barnett JK, 1999, INFECT IMMUN, V67, P853
  7. CAMPISTOL JM, 1989, J HOSP INFECT, V14, P267, DOI 10.1016/0195-6701(89)90047-9
  8. Chang MY, 2016, SCI REP-UK, V6, DOI 10.1038/srep27838
  9. CHUN CH, 1985, DIAGN MICR INFEC DIS, V3, P257, DOI 10.1016/0732-8893(85)90038-0
  10. CORWIN HL, 1984, ARCH INTERN MED, V144, P981, DOI 10.1001/archinte.144.5.981
  11. Costa F, 2015, PLOS NEGLECT TROP D, V17, P9
  12. Daher E.F., 2010, J BRAS NEFROL, V32, P400
  13. Daher EF, 2009, NEPHRON CLIN PRACT, V112, pC25, DOI 10.1159/000210571
  14. Faine S. B., 1999, LEPTOSPIRA LEPTOSPIR
  15. Fouts DE, 2016, PLOS NEGLECT TROP D, V10, DOI 10.1371/journal.pntd.0004403
  16. FRIMAN G, 1984, SCAND J INFECT DIS, V16, P111, DOI 10.3109/00365548409068416
  17. Gamberini M, 2005, FEMS MICROBIOL LETT, V244, P305, DOI 10.1016/j.femsle.2005.02.004
  18. Haake DA, 2000, INFECT IMMUN, V68, P2276, DOI 10.1128/IAI.68.4.2276-2285.2000
  19. Haake DA, 2002, INFECT IMMUN, V70, P4936, DOI 10.1128/IAI.70.9.4936-4945.2002
  20. Haake DA, 2015, CURR TOP MICROBIOL, V387, P65, DOI 10.1007/978-3-662-45059-8_5
  21. Hartwig DD, 2011, CURR MICROBIOL, V62, P1337, DOI 10.1007/s00284-010-9865-1
  22. JOHNSON DA, 1984, SOUTHERN MED J, V77, P777, DOI 10.1097/00007611-198406000-00032
  23. Khan FY, 2009, NETH J MED, V67, P272
  24. Liborio AB, 2005, NEPHROL DIAL TRANSPL, V20, P2580, DOI 10.1093/ndt/gfi073
  25. Lo M, 2009, PLOS NEGLECT TROP D, V3, DOI 10.1371/journal.pntd.0000560
  26. MAGALDI AJ, 1992, NEPHRON, V62, P332, DOI 10.1159/000187069
  27. Malmstrom J, 2009, NATURE, V460, P762, DOI 10.1038/nature08184
  28. Marotto PCF, 1999, CLIN INFECT DIS, V29, P1561, DOI 10.1086/313501
  29. Martinelli Reinaldo, 1994, Revista do Instituto de Medicina Tropical de Sao Paulo, V36, P111, DOI 10.1590/S0036-46651994000200003
  30. Matsunaga J, 2003, MOL MICROBIOL, V49, P929, DOI 10.1046/j.1365-2958.2003.03619.x
  31. MCKINNEY MM, 1987, J IMMUNOL METHODS, V96, P271, DOI 10.1016/0022-1759(87)90324-3
  32. Monaris D, 2015, CLIN VACCINE IMMUNOL, V22, P965, DOI 10.1128/CVI.00285-15
  33. Murray GL, 2013, VET MICROBIOL, V162, P305, DOI 10.1016/j.vetmic.2012.11.005
  34. Murray GL, 2009, INFECT IMMUN, V77, P952, DOI 10.1128/IAI.01370-08
  35. Nascimento ALTO, 2004, BRAZ J MED BIOL RES, V37, P459, DOI 10.1590/S0100-879X2004000400003
  36. Petejova N, 2014, CRIT CARE, V18, DOI 10.1186/cc13897
  37. Pinne M, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0051025
  38. Prosser CL, 1973, WATER OSMOTIC BALANC
  39. Ramos CRR, 2004, BRAZ J MED BIOL RES
  40. SEGURO AC, 1990, NEPHRON, V55, P146, DOI 10.1159/000185943
  41. Silva Junior GB, 2001, NEPHROLOGY, V16, P269
  42. Stevenson B, 2007, PLOS ONE, V2, DOI 10.1371/journal.pone.0001188
  43. Tatusova T., 2013, NCBI HDB
  44. Verma A, 2006, INFECT IMMUN, V74, P2659, DOI 10.1128/IAI.74.5.2659-2666.2006
  45. Verma A, 2010, INFECT IMMUN, V78, P2053, DOI 10.1128/IAI.01282-09
  46. Yang CW, 2002, J AM SOC NEPHROL, V13, P2037, DOI 10.1097/01.ASN.0000022007.91733.62

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - IMT
Artigos e Materiais de Revistas Científicas - LIM/06
Artigos e Materiais de Revistas Científicas - LIM/12