Three-Dimensional Changes of Maxilla after Secondary Alveolar Cleft Repair: Differences Between rhBMP-2 and Autologous Iliac Crest Bone Grafting

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorRAPOSO-AMARAL, Cassio Eduardo
dc.contributor.authorDENADAI, Rafael
dc.contributor.authorALONSO, Nivaldo
dc.date.accessioned2019-05-30T13:17:52Z
dc.date.available2019-05-30T13:17:52Z
dc.date.issued2015
dc.description.abstractBackground: Recombinant human bone morphogenetic protein (rhBMP)-2 has been used as an alternative to autologous bone transferring, a standard method of treatment. However, its potential adverse effect on anterior maxillary arch is unknown. Thus, the purpose of this study was to quantify sagittal and transversal changes of anterior maxilla after secondary alveolar cleft repair using traditional iliac crest bone grafting versus rhBMP-2. Methods: Twelve unilateral complete cleft lip and palate patients were randomly divided into 2 groups. In group 1, patients underwent traditional iliac crest bone grafting transferring (n = 4), and in group 2, patients underwent alveolar cleft reconstruction using collagen matrix with lyophilized rhBMP-2 (n = 8). Computed tomography (CT) imaging was performed preoperatively and at 1 year postoperatively, using a previously standardized protocol. A three-dimensional (3D) CT cephalometric analysis of the linear and angular measurements of the sagittal and transverse maxilla planes was performed to assess intra-and intergroup maxillary changes. Results: Intra-and intergroup comparisons of the pre-and postoperative 3D CT cephalometric linear and angular measurements of the sagittal and transverse maxilla planes showed no significant (all P > 0.05) differences among all studied variables. Conclusions: There were no significant anterior maxilla changes after maxillary cleft repair either using iliac crest bone grafting or rhBMP-2.eng
dc.description.indexPubMedeng
dc.description.sponsorshipFAPESP [201008175-6)]
dc.description.sponsorshipCAPES (postdoctoral student grant, Universidade de Sao Paulo, Sao Paulo, Brazil)
dc.identifier.citationPLASTIC AND RECONSTRUCTIVE SURGERY-GLOBAL OPEN, v.3, n.7, article ID e451, 8p, 2015
dc.identifier.doi10.1097/GOX.0000000000000417
dc.identifier.issn2169-7574
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/31574
dc.language.isoeng
dc.publisherLIPPINCOTT WILLIAMS & WILKINSeng
dc.relation.ispartofPlastic and Reconstructive Surgery-Global Open
dc.rightsopenAccesseng
dc.rights.holderCopyright LIPPINCOTT WILLIAMS & WILKINSeng
dc.subject.wosSurgeryeng
dc.titleThree-Dimensional Changes of Maxilla after Secondary Alveolar Cleft Repair: Differences Between rhBMP-2 and Autologous Iliac Crest Bone Graftingeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalDENADAI, Rafael:SOBRAPAR Hosp, Inst Plast & Craniofacial Surg, Campinas, SP, Brazil
hcfmusp.citation.scopus9
hcfmusp.contributor.author-fmusphcCASSIO EDUARDO ADAMI RAPOSO DO AMARAL
hcfmusp.contributor.author-fmusphcNIVALDO ALONSO
hcfmusp.description.articlenumbere451
hcfmusp.description.issue7
hcfmusp.description.volume3
hcfmusp.origemWOS
hcfmusp.origem.pubmed26301140
hcfmusp.origem.scopus2-s2.0-85027433935
hcfmusp.origem.wosWOS:000219079300012
hcfmusp.publisher.cityPHILADELPHIAeng
hcfmusp.publisher.countryUSAeng
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