Prefrontal-Parietal White Matter Volumes in Healthy Elderlies Are Decreased in Proportion to the Degree of Cardiovascular Risk and Related to Inhibitory Control Deficits

Imagem de Miniatura
Arquivos
art_SANTOS_PrefrontalParietal_White_Matter_Volumes_in_Healthy_Elderlies_Are_2017.PDF (1.55 MB)
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2017
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
FRONTIERS MEDIA SA
Autores
Citação
FRONTIERS IN PSYCHOLOGY, v.8, article ID 57, 11p, 2017
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Cardiovascular risk (CVR) factors may be associated with poor cognitive functioning in elderlies and impairments in brain structure. Using MRI and voxel-based morphometry (VBM), we assessed regional white matter (WM) volumes in a population-based sample of individuals aged 65-75 years (n = 156), subdivided in three CVR subgroups using the Framingham Risk Score. Cognition was assessed using the Short Cognitive Performance Test. In high-risk subjects, we detected significantly reduced WM volume in the right juxtacortical dorsolateral prefrontal region compared to both low and intermediate CVR subgroups. Findings remained significant after accounting for the presence of the APOE epsilon 4 allele. Inhibitory control performance was negatively related to right prefrontal WM volume, proportionally to the degree of CVR. Significantly reduced deep parietal WM was also detected bilaterally in the high CVR subgroup. This is the first large study documenting the topography of CVR-related WM brain volume deficits. The significant association regarding poor response inhibition indicates that prefrontal WM deficits related to CVR are clinically meaningful, since inhibitory control is known to rely on prefrontal integrity.
Palavras-chave
voxel-based morphometry (VBM), framingham risk factor, cognition, APOE epsilon 4 allele, MRI imaging
URI
https://observatorio.fm.usp.br/handle/OPI/18923
Referências
  1. Alves TCTF, 2005, J NEUROIMAGING, V15, P150, DOI 10.1177/1051228404272880
  2. Anbeek P, 2004, NEUROIMAGE, V21, P1037, DOI 10.1016/j.neuroimage.2003.10.012
  3. Ashburner J, 2005, NEUROIMAGE, V26, P839, DOI 10.1016/j.neuroimage.2005.02.018
  4. Ashburner J, 2007, NEUROIMAGE, V38, P95, DOI 10.1016/j.neuroimage.2007.07.007
  5. Au R, 2006, ARCH NEUROL-CHICAGO, V63, P246, DOI 10.1001/archneur.63.2.246
  6. Barker R, 2014, BRAIN, V137, P1524, DOI 10.1093/brain/awu040
  7. Bennet AM, 2007, JAMA-J AM MED ASSOC, V298, P1300, DOI 10.1001/jama.298.11.1300
  8. Brett M, 2002, NAT REV NEUROSCI, V3, P243, DOI 10.1038/nrn756
  9. Caligiuri ME, 2015, NEUROINFORMATICS, V13, P261, DOI 10.1007/s12021-015-9260-y
  10. Catani M, 2008, CORTEX, V44, P1105, DOI 10.1016/j.cortex.2008.05.004
  11. Chen ZY, 2012, EUR J RADIOL, V81, P1870, DOI 10.1016/j.ejrad.2011.04.025
  12. COPELAND JRM, 1986, PSYCHOL MED, V16, P89
  13. Coryell W, 2005, AM J PSYCHIAT, V162, P1706, DOI 10.1176/appi.ajp.162.9.1706
  14. Craggs LJL, 2014, NEUROPATH APPL NEURO, V40, P591, DOI 10.1111/nan.12073
  15. Craggs LJL, 2014, BRAIN PATHOL, V24, P495, DOI 10.1111/bpa.12177
  16. Alves TCDF, 2011, J ALZHEIMERS DIS, V27, P575, DOI 10.3233/JAD-2011-110827
  17. Debette S, 2011, NEUROLOGY, V77, P461, DOI 10.1212/WNL.0b013e318227b227
  18. Thiebaut de Schotten M, 2014, CEREB CORTEX, V24, P691, DOI 10.1093/CERCOR/BHS351
  19. Dowell NG, 2016, NMR BIOMED, V29, P614, DOI 10.1002/nbm.3502
  20. Flaks MK, 2006, INT PSYCHOGERIATR, V18, P121, DOI 10.1017/S1041610205002577
  21. Freedman BI, 2015, DIABETES CARE, V38, P2158, DOI 10.2337/dc15-1035
  22. Gebeily S, 2014, INT J NEUROSCI, V124, P799, DOI 10.3109/00207454.2014.884087
  23. Gold BT, 2012, BBA-MOL BASIS DIS, V1822, P416, DOI 10.1016/j.bbadis.2011.07.009
  24. Gouw AA, 2011, J NEUROL NEUROSUR PS, V82, P126, DOI 10.1136/jnnp.2009.204685
  25. Grundy SM, 1998, CIRCULATION, V97, P1876
  26. Grundy SM, 1999, CIRCULATION, V100, P1481
  27. Gunstad J, 2008, INT J NEUROSCI, V118, P1582, DOI 10.1080/00207450701392282
  28. Haroutunian V, 2014, GLIA, V62, P1856, DOI 10.1002/glia.22716
  29. Hayden KM, 2014, AM J GERIAT PSYCHIAT, V22, P1364, DOI 10.1016/j.jagp.2013.07.008
  30. Hedna VS, 2013, J CLIN NEUROL, V9, P97, DOI 10.3988/jcn.2013.9.2.97
  31. Homayoon N, 2013, CLIN NEUROL NEUROSUR, V115, P1317, DOI 10.1016/j.clineuro.2012.12.016
  32. Ikram MA, 2008, NEUROBIOL AGING, V29, P882, DOI 10.1016/j.neurobiolaging.2006.12.012
  33. Ito Hirono, 2008, J Stroke Cerebrovasc Dis, V17, P35, DOI 10.1016/j.jstrokecerebrovasdis.2007.11.002
  34. Ito K, 2015, J ALZHEIMERS DIS, V45, P543, DOI 10.3233/JAD-141338
  35. Janson J, 2004, DIABETES, V53, P474, DOI 10.2337/diabetes.53.2.474
  36. Jeerakathil T, 2004, STROKE, V35, P1857, DOI 10.1161/01.STR.0000135226.53499.85
  37. Kawachi I, 2015, NEUROPATHOLOGY, V35, P481, DOI 10.1111/neup.12216
  38. Kearney-Schwartz A, 2009, STROKE, V40, P1229, DOI 10.1161/STROKEAHA.108.532853
  39. Knopman D, 2001, NEUROLOGY, V56, P42
  40. Last D, 2007, DIABETES CARE, V30, P1193, DOI 10.2337/dc06-2052
  41. Launer LJ, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0122138
  42. Lehfeld H, 1997, Int Psychogeriatr, V9 Suppl 1, P115, DOI 10.1017/S104161029700478X
  43. Lehfeld H, 1997, Int Psychogeriatr, V9, P139, DOI 10.1017/S1041610297004304
  44. Lindquist MA, 2015, PSYCHOSOM MED, V77, P114, DOI 10.1097/PSY.0000000000000148
  45. Maillard P, 2012, LANCET NEUROL, V11, P1039, DOI 10.1016/S1474-4422(12)70241-7
  46. Markus HS, 2005, STROKE, V36, P1410, DOI 10.1161/01.STR.0000169924.60783.d4
  47. Masouleh SK, 2016, NEUROBIOL AGING, V40, P1, DOI 10.1016/j.neurobiolaging.2015.12.020
  48. Matsuda H, 2012, AM J NEURORADIOL, V33, P1109, DOI 10.3174/ajnr.A2935
  49. Mechelli A, 2005, J NEUROSCI, V25, P8303, DOI 10.1523/JNEUROSCI.0357-05.2005
  50. Moran C, 2013, DIABETES CARE, V36, P4036, DOI 10.2337/dc13-0143
  51. Mori S, 2008, NEUROIMAGE, V40, P570, DOI 10.1016/j.neuroimage.2007.12.035
  52. Mortamais M, 2014, J ALZHEIMERS DIS, V42, pS393, DOI 10.3233/JAD-141473
  53. Naess Halvor, 2006, J Stroke Cerebrovasc Dis, V15, P241, DOI 10.1016/j.jstrokecerebrovasdis.2006.06.003
  54. Nunley KA, 2015, NEUROLOGY, V84, P2062, DOI 10.1212/WNL.0000000000001582
  55. O'Brien JT, 2014, AM J GERIAT PSYCHIAT, V22, P133, DOI 10.1016/j.jagp.2013.07.006
  56. Paul RH, 2008, NICOTINE TOB RES, V10, P137, DOI 10.1080/14622200701767829
  57. Petrou M, 2016, ACAD RADIOL, V23, P577, DOI 10.1016/j.acra.2015.07.014
  58. Picton TW, 2007, CEREB CORTEX, V17, P826, DOI 10.1093/cercor/bhk031
  59. Pierdomenico SD, 2016, AM J HYPERTENS, V29, P365, DOI 10.1093/ajh/hpv121
  60. Prince M, 2003, LANCET, V361, P909, DOI 10.1016/S0140-6736(03)12772-9
  61. Prins ND, 2015, NAT REV NEUROL, V11, DOI 10.1038/nrneurol.2015.10
  62. Radanovic M, 2013, EXPERT REV NEUROTHER, V13, P483, DOI [10.1586/ern.13.45, 10.1586/ERN.13.45]
  63. Raz N, 2003, BEHAV NEUROSCI, V117, P1169, DOI 10.1037/0735-7044.117.6.1169
  64. Razay G, 2007, ARCH NEUROL-CHICAGO, V64, P93, DOI 10.1001/archneur.64.1.93
  65. Rostrup E, 2012, NEUROIMAGE, V60, P1597, DOI 10.1016/j.neuroimage.2012.01.106
  66. Salmond CH, 2002, NEUROIMAGE, V17, P507, DOI 10.1006/nimg.2002.1191
  67. Scazufca M, 2008, INT PSYCHOGERIATR, V20, P394, DOI 10.1017/S1041610207005625
  68. Segura B, 2009, NEUROLOGY, V73, P438, DOI 10.1212/WNL.0b013e3181b163cd
  69. Segura B, 2010, BMC NEUROL, V10, DOI 10.1186/1471-2377-10-64
  70. Selwaness M, 2014, STROKE, V45, P3226, DOI 10.1161/STROKEAHA.114.005202
  71. Seshadri S, 2006, STROKE, V37, P345, DOI 10.1161/01.STR.0000199613.38911.b2
  72. Seshadri S, 2006, INT REV PSYCHIATR, V18, P409, DOI 10.1080/09540260600935413
  73. Smith EE, 2015, ANN NEUROL, V77, P251, DOI 10.1002/ana.24320
  74. Smith PJ, 2010, AM J GERIAT PSYCHIAT, V18, P848, DOI 10.1097/JGP.0b013e3181dba0fa
  75. Soderlund H, 2003, CORTEX, V39, P1093, DOI 10.1016/S0010-9452(08)70879-7
  76. Tham MW, 2011, J AFFECT DISORDERS, V132, P26, DOI 10.1016/j.jad.2010.09.013
  77. Thomas AJ, 2002, ARCH GEN PSYCHIAT, V59, P785, DOI 10.1001/archpsyc.59.9.785
  78. Thomas AJ, 2003, INT J GERIATR PSYCH, V18, P7, DOI 10.1002/gps.720
  79. Thomas T, 2015, BRAIN, V138, P1059, DOI 10.1093/brain/awv025
  80. Tullberg M, 2004, NEUROLOGY, V63, P246
  81. van Bloemendaal L, 2016, METAB BRAIN DIS, V31, P621, DOI 10.1007/s11011-016-9792-3
  82. Walther K, 2010, HUM BRAIN MAPP, V31, P1052, DOI 10.1002/hbm.20916
  83. Wang R, 2015, NEUROLOGY, V84, P1128, DOI 10.1212/WNL.0000000000001379
  84. Wang YL, 2016, BEHAV BRAIN RES, V298, P301, DOI 10.1016/j.bbr.2015.10.040
  85. Wechsler D., 1999, WECHSLER ABBREVIATED
  86. Williams LR, 2010, ARCH GERONTOL GERIAT, V50, P127, DOI 10.1016/j.archger.2009.02.012
  87. Wilson PWF, 1998, CIRCULATION, V97, P1837
  88. Wishart HA, 2006, NEUROLOGY, V67, P1221, DOI 10.1212/01.wnl.0000238079.00472.3a
  89. Wolf PA, 2007, CURR ALZHEIMER RES, V4, P111, DOI 10.2174/156720507780362263
  90. Worsley KJ, 1996, HUM BRAIN MAPP, V4, P58, DOI 10.1002/(SICI)1097-0193(1996)4:1<58::AID-HBM4>3.0.CO;2-O
  91. Yokoyama JS, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0118338

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPR
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/InCor
Artigos e Materiais de Revistas Científicas - HC/InRad
Carregar mais