Evaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phases

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVESTRE, Marilene Chaves
dc.contributor.authorREIS, Vitor Manoel Silva dos
dc.date.accessioned2019-01-17T13:29:34Z
dc.date.available2019-01-17T13:29:34Z
dc.date.issued2018
dc.description.abstractBACKGROUND: Allergic contact dermatitis to ion nickel (Ni+2) is an inflammatory dermatosis, common in industrialized countries. It involves the activation of nickel-specific T-cells, followed by proliferation and induction of a mixed profile of both proinflammatory and regulatory cytokines, suggesting that several T-cell subtypes (helper - Th and cytotoxic - Tc) are involved. A broader understanding of the cytokine profile may lead to new therapeutic approaches. OBJECTIVES: This study aimed to analyze the cytokines TNF-alpha, INIF-gamma, IL-2, IL-4, IL-10, IL-13, IL-17 and IL-23 using the inununohistochemistry technique in order to try to identify their prevalence in chronic and acute eczema of patients with allergic contact dermatitis to Ni+2. METHODS: We performed an immunohistochemical study for eight cytokines in 20 patients with Ni+2 allergic contact dermatitis, biopsied at the site of chronic eczema, triggered by the patient's daily contact with Ni+2, and at the site of acute eczema caused by nickel sulfate, 48 hours after applying the contact test. RESULTS: The stained samples showed positive results for the eight cytokines studied. TNF-alpha, IFN-gamma, IL-4, IL-13 and IL-17 had a higher prevalence in chronic eczema, IL-2 and IL-23 in acute eczema, and IL-10 presented a similar prevalence in both acute and chronic eczema. However, these prevalences were statistically significant only for IL-4 and IL-13. STUDY LIMITATIONS: Small sample size. CONCLUSIONS: In chronic and acute eczema, we observed the presence of a mixed cytokine profile of the T cell subtypes (Th/Tc), suggesting that the responses are expressed at the same time.eng
dc.description.indexMEDLINEeng
dc.identifier.citationANAIS BRASILEIROS DE DERMATOLOGIA, v.93, n.6, p.829-835, 2018
dc.identifier.doi10.1590/abd1806-4841.20187126
dc.identifier.eissn1806-4841
dc.identifier.issn0365-0596
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29902
dc.language.isoeng
dc.publisherSOC BRASILEIRA DERMATOLOGIAeng
dc.relation.ispartofAnais Brasileiros de Dermatologia
dc.rightsopenAccesseng
dc.rights.holderCopyright SOC BRASILEIRA DERMATOLOGIAeng
dc.subjectAllergy and immunologyeng
dc.subjectCytokineseng
dc.subjectDermatitiseng
dc.subjectallergic contacteng
dc.subjectDermatitiseng
dc.subjectcontacteng
dc.subjectImmunohistochemistryeng
dc.subjectNickeleng
dc.subject.otherblood mononuclear-cellseng
dc.subject.otherimmune eventseng
dc.subject.otherinterleukin-17eng
dc.subject.otheractivationeng
dc.subject.otherhypersensitivityeng
dc.subject.otherindividualseng
dc.subject.otherimmunologyeng
dc.subject.otherexpressioneng
dc.subject.othersecretioneng
dc.subject.othergeneticseng
dc.subject.wosDermatologyeng
dc.titleEvaluation of the profile of inflammatory cytokines, through immunohistochemistry, in the skin of patients with allergic contact dermatitis to nickel in the acute and chronic phaseseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSILVESTRE, Marilene Chaves:Univ Fed Goias, Dept Trop Med & Dermatol, Goiania, Go, Brazil
hcfmusp.citation.scopus13
hcfmusp.contributor.author-fmusphcVITOR MANOEL SILVA DOS REIS
hcfmusp.description.beginpage829
hcfmusp.description.endpage835
hcfmusp.description.issue6
hcfmusp.description.volume93
hcfmusp.origemWOS
hcfmusp.origem.pubmed30484527
hcfmusp.origem.scieloSCIELO:S0365-05962018000600829
hcfmusp.origem.scopus2-s2.0-85057226816
hcfmusp.origem.wosWOS:000451001800007
hcfmusp.publisher.cityRIO DE JANEIRO RJeng
hcfmusp.publisher.countryBRAZILeng
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