Activity of cycloartane-type triterpenes and sterols isolated from Musa paradisiaca fruit peel against Leishmania infantum chagasi

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSILVA, A. A. S.
dc.contributor.authorMORAIS, S. M.
dc.contributor.authorFALCAO, M. J. C.
dc.contributor.authorVIEIRA, I. G. P.
dc.contributor.authorRIBEIRO, L. M.
dc.contributor.authorVIANA, S. M.
dc.contributor.authorTEIXEIRA, M. J.
dc.contributor.authorBARRETO, F. S.
dc.contributor.authorCARVALHO, C. A.
dc.contributor.authorCARDOSO, R. P. A.
dc.contributor.authorANDRADE-JUNIOR, H. F.
dc.date.accessioned2015-02-06T19:47:55Z
dc.date.available2015-02-06T19:47:55Z
dc.date.issued2014
dc.description.abstractThe aim of the study was to evaluate in vitro the antileishmanial activity of triterpenes and sterols isolated from Musa paradisiaca (banana) fruit peel used traditionally to treat leishmaniasis. The compounds were isolated from the ethanolic extract of the peel of the banana fruit by column chromatography. The chemical structure of compounds was determined by H-1 and C-13 - nuclear magnetic resonance spectroscopy. The cytotoxicity was measured in RAW 264.7 cells and LLC-MK2. Leishmanicidal activity against L infantum chagasi promastigotes was performed by the MTT colorimetric method and activity against amastigotes was assayed in mammalian cells using in situ ELISA method. Five compounds were identified, consisting of three triterpenes: cycloeucalenone, 31-norcyclolaudenone and 24-methylene-cicloartanol and a mixture of two sterols: beta-sitosterol and stigmasterol. With the exception of cycloeucalenone, all compounds showed statistically similar activity against promastigote to peritamidine. While, acting against amastigotes, excluding 31-norcyclolaudenone, other compounds showed activity similar to amphotericin B. All compounds showed low cytotoxicity in mammalian cells. Conclusion: This study partially confirms the use of Musa paradisiaca in folk medicine against leishmaniasis. Further in vivo studies are necessary to evaluate the efficacy.
dc.description.indexMEDLINE
dc.description.sponsorshipCeara State Government Foundation for Scientifical and Technological Development (FUNCAP)
dc.description.sponsorshipBrazilian Counsel for Scientifical and Technological Development (CNPq)
dc.identifier.citationPHYTOMEDICINE, v.21, n.11, p.1419-1423, 2014
dc.identifier.doi10.1016/j.phymed.2014.05.005
dc.identifier.issn0944-7113
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/8653
dc.language.isoeng
dc.publisherELSEVIER GMBH, URBAN & FISCHER VERLAG
dc.relation.ispartofPhytomedicine
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER GMBH, URBAN & FISCHER VERLAG
dc.subjectSterols
dc.subjectTriterpenes
dc.subjectLeishmania infantum chagasi
dc.subject.otherphytosterols
dc.subject.otherglycosides
dc.subject.otherextracts
dc.subject.wosPlant Sciences
dc.subject.wosChemistry, Medicinal
dc.subject.wosIntegrative & Complementary Medicine
dc.subject.wosPharmacology & Pharmacy
dc.titleActivity of cycloartane-type triterpenes and sterols isolated from Musa paradisiaca fruit peel against Leishmania infantum chagasi
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalSILVA, A. A. S.:Univ Estadual Ceara, Programa Posgrad Ciencias Vet, BR-60714903 Fortaleza, Ceara, Brazil
hcfmusp.author.externalMORAIS, S. M.:Univ Estadual Ceara, Programa Posgrad Ciencias Vet, BR-60714903 Fortaleza, Ceara, Brazil; Univ Estadual Ceara, Curso Quim, BR-60714903 Fortaleza, Ceara, Brazil
hcfmusp.author.externalFALCAO, M. J. C.:Univ Estadual Ceara, Curso Quim, BR-60714903 Fortaleza, Ceara, Brazil
hcfmusp.author.externalVIEIRA, I. G. P.:Univ Estadual Ceara, Curso Quim, BR-60714903 Fortaleza, Ceara, Brazil
hcfmusp.author.externalRIBEIRO, L. M.:Univ Estadual Ceara, Curso Quim, BR-60714903 Fortaleza, Ceara, Brazil
hcfmusp.author.externalVIANA, S. M.:Univ Fed Ceara, Dept Patol & Med Legal, Fortaleza, Ceara, Brazil
hcfmusp.author.externalTEIXEIRA, M. J.:Univ Fed Ceara, Dept Patol & Med Legal, Fortaleza, Ceara, Brazil
hcfmusp.author.externalBARRETO, F. S.:Univ Fed Ceara, Dept Fisiol & Farmacol, Fortaleza, Ceara, Brazil
hcfmusp.citation.scopus34
hcfmusp.contributor.author-fmusphcCAMILA APARECIDA DE CARVALHO
hcfmusp.contributor.author-fmusphcROSELAINE PEREIRA ALVIM CARDOSO
hcfmusp.contributor.author-fmusphcHEITOR FRANCO DE ANDRADE JUNIOR
hcfmusp.description.beginpage1419
hcfmusp.description.endpage1423
hcfmusp.description.issue11
hcfmusp.description.volume21
hcfmusp.origemWOS
hcfmusp.origem.scopus2-s2.0-84906934801
hcfmusp.origem.wosWOS:000341741900025
hcfmusp.publisher.cityJENA
hcfmusp.publisher.countryGERMANY
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