Pro-Inflammatory Diet Is Correlated with High Veillonella rogosae, Gut Inflammation and Clinical Relapse of Inflammatory Bowel Disease
Carregando...
Citações na Scopus
3
Tipo de produção
article
Data de publicação
2023
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Autores
LYRA, Clelia de Oliveira
NERI, Julianna Lys de Sousa Alves
CHARLTON, Karen
Citação
NUTRIENTS, v.15, n.19, article ID 4148, 12p, 2023
Resumo
Inflammatory bowel diseases (IBD) are chronic conditions arising from an intricate interplay of genetics and environmental factors, and are associated with gut dysbiosis, inflammation, and gut permeability. In this study, we investigated whether the inflammatory potential of the diet is associated with the gut microbiota profile, inflammation, and permeability in forty patients with IBD in clinical remission. The dietary inflammatory index (DII) score was used to assess the inflammatory potential of the diet. The fecal microbiota profile was analyzed using 16SrRNA (V3-V4) gene sequencing, while fecal zonulin and calprotectin levels were measured with enzyme-linked immunosorbent assays. We found a positive correlation between the DII score and elevated calprotectin levels (Rho = 0.498; p = 0.001), but not with zonulin levels. Although alpha- and beta-diversity did not significantly differ across DII quartiles, the most pro-inflammatory diet group exhibited a higher fecal abundance of Veillonella rogosae (p = 0.026). In addition, the abundance of some specific bacteria sequences showed an exponential behavior across DII quartiles and a correlation with calprotectin or zonulin levels (p <= 0.050). This included a positive correlation between sq702. Veillonella rogosae and fecal calprotectin levels (Rho = 0.419, p = 0.007). DII, calprotectin, and zonulin levels were identified as significant predictors of 6-month disease relapse (p <= 0.050). Our findings suggest a potential relationship of a pro-inflammatory diet intake with Veillonella rogosae and calprotectin levels in IBD patients in clinical remission, which may contribute to disease relapse.
Palavras-chave
dietary inflammatory index, ulcerative colitis, Crohn's disease, gut microbiota, inflammation, calprotectin, zonulin
Referências
- Ananthakrishnan AN, 2018, NAT REV GASTRO HEPAT, V15, P39, DOI 10.1038/nrgastro.2017.136
- [Anonymous], 1995, Physical Status: the use and interpretation of anthropometry: report of a world health organization (WHO) expert committee, V854, P1, DOI 10.1002/(sici)1520-6300(1996)8:63.0.co;2-i
- Bertani L, 2021, NUTRIENTS, V13, DOI 10.3390/nu13041387
- Bian DS, 2022, NUTRIENTS, V14, DOI 10.3390/nu14040901
- Bolte LA, 2021, GUT, V70, P1287, DOI 10.1136/gutjnl-2020-322670
- Bourgonje AR, 2022, NUTRIENTS, V14, DOI 10.3390/nu14122522
- Brazilian Institute of Geography and Statistics (IBGE), 2011, Table of Measures Referred to the Foods Consumed in Brazil
- Butera A, 2020, J CROHNS COLITIS, V14, P369, DOI 10.1093/ecco-jcc/jjz154
- Callahan BJ, 2016, NAT METHODS, V13, P581, DOI [10.1038/NMETH.3869, 10.1038/nmeth.3869]
- Caviglia GP, 2019, MINERVA MED, V110, P95, DOI 10.23736/S0026-4806.18.05787-7
- Cronin P, 2021, NUTRIENTS, V13, DOI 10.3390/nu13051655
- Cui YL, 2022, FEMS MICROBIOL LETT, V369, DOI 10.1093/femsle/fnac072
- Das P, 2019, BMC GENOMICS, V20, DOI 10.1186/s12864-019-5899-3
- de Graaf MCG, 2022, NUTRIENTS, V14, DOI 10.3390/nu14091945
- de Vries JHM, 2019, DIGEST DIS, V37, P131, DOI 10.1159/000494022
- Dione N., 2017, New Microbes and New Infections, V18, P38, DOI 10.1016/j.nmni.2017.05.003
- Fasano Alessio, 2020, F1000Res, V9, DOI 10.12688/f1000research.20510.1
- Fiocchi C, 2018, FRONT MED-LAUSANNE, V5, DOI 10.3389/fmed.2018.00075
- Freeman K, 2019, BMJ OPEN, V9, DOI 10.1136/bmjopen-2018-027428
- Fuke N, 2019, NUTRIENTS, V11, DOI 10.3390/nu11102277
- Gevers D, 2014, CELL HOST MICROBE, V15, P382, DOI 10.1016/j.chom.2014.02.005
- Gomollon F, 2017, J CROHNS COLITIS, V11, P3, DOI 10.1093/ecco-jcc/jjw168
- Guardiola J, 2014, CLIN GASTROENTEROL H, V12, P1865, DOI 10.1016/j.cgh.2014.06.020
- Guo X, 2022, FRONT NUTR, V8, DOI 10.3389/fnut.2021.818902
- HARVEY RF, 1980, LANCET, V1, P1134
- Haubrock J., 2010, Arch. Public Health, V68, P14
- Jukic A, 2021, GUT, V70, P1978, DOI 10.1136/gutjnl-2021-324855
- Kaakoush NO, 2020, TRENDS MICROBIOL, V28, P519, DOI 10.1016/j.tim.2020.02.018
- Khalil H, 2018, GUT, V67, pA29, DOI 10.1136/gutjnl-2018-BSGAbstracts.55
- Khalili H, 2018, NAT REV GASTRO HEPAT, V15, P525, DOI 10.1038/s41575-018-0022-9
- Kordjazy N, 2018, PHARMACOL RES, V129, P204, DOI 10.1016/j.phrs.2017.11.017
- Lamers CR, 2020, BMC GASTROENTEROL, V20, DOI 10.1186/s12876-020-01435-4
- Larussa T, 2017, WORLD J GASTROENTERO, V23, P2483, DOI 10.3748/wjg.v23.i14.2483
- Levine A, 2019, GASTROENTEROLOGY, V157, P440, DOI 10.1053/j.gastro.2019.04.021
- Lewis JD, 2017, GASTROENTEROLOGY, V152, P398, DOI 10.1053/j.gastro.2016.10.019
- Li JL, 2022, ANAEROBE, V78, DOI 10.1016/j.anaerobe.2022.102667
- Liu F, 2020, FRONT MED-LAUSANNE, V7, DOI 10.3389/fmed.2020.580803
- Ma YS, 2009, ANN EPIDEMIOL, V19, P553, DOI 10.1016/j.annepidem.2009.04.010
- Magro F, 2017, J CROHNS COLITIS, V11, P649, DOI 10.1093/ecco-jcc/jjx008
- Malícková K, 2017, PRACT LAB MED, V9, P39, DOI 10.1016/j.plabm.2017.09.001
- Mentella MC, 2020, NUTRIENTS, V12, DOI 10.3390/nu12040944
- Mirmiran P, 2019, NUTR J, V18, DOI 10.1186/s12937-019-0492-9
- Mosli MH, 2015, AM J GASTROENTEROL, V110, P802, DOI 10.1038/ajg.2015.120
- Ng SC, 2017, LANCET, V390, P2769, DOI 10.1016/S0140-6736(17)32448-0
- Pittayanon R, 2020, GASTROENTEROLOGY, V158, P930, DOI 10.1053/j.gastro.2019.11.294
- Poppleton DI, 2017, FRONT MICROBIOL, V8, DOI 10.3389/fmicb.2017.01215
- Quast Christian, 2013, Nucleic Acids Res, V41, pD590, DOI 10.1093/nar/gks1219
- Rai AK, 2021, ARCH MICROBIOL, V203, P137, DOI 10.1007/s00203-020-02011-w
- Rajilic-Stojanovic M, 2015, AM J GASTROENTEROL, V110, P278, DOI 10.1038/ajg.2014.427
- Ramos GP, 2019, MAYO CLIN PROC, V94, P155, DOI 10.1016/j.mayocp.2018.09.013
- Ribaldone DG, 2019, CLIN EXP GASTROENTER, V12, P321, DOI 10.2147/CEG.S210844
- Rizzello F, 2019, NUTRIENTS, V11, DOI 10.3390/nu11051033
- Sandborn WJ, 2012, GASTROENTEROLOGY, V142, P257, DOI 10.1053/j.gastro.2011.10.032
- Shivappa N, 2014, PUBLIC HEALTH NUTR, V17, P1689, DOI 10.1017/S1368980013002115
- The Multiple Source Method (MSM), 2011, Department of Epidemiology of the German Institute of Human Nutrition Potsdam-Rehbrucke (DiFE)
- Tian ZY, 2022, CLIN NUTR, V41, DOI 10.1016/j.clnu.2022.04.014
- Tian ZY, 2021, ADV NUTR, V12, P2288, DOI 10.1093/advances/nmab069
- US Department of Agriculture, 2015, USDA Database for the Flavonoid Content of Selected Foods: Release 3.2
- Vagianos Kathy, 2021, Inflamm Bowel Dis, V27, P190, DOI 10.1093/ibd/izaa052
- Witkowski M, 2018, SEMIN IMMUNOPATHOL, V40, P145, DOI 10.1007/s00281-017-0658-5
- Yang RX, 2021, FRONT MED-LAUSANNE, V8, DOI 10.3389/fmed.2021.663920
- Zheng JL, 2020, BRIT J NUTR, V124, P931, DOI 10.1017/S0007114520001853
- Zmora N, 2019, NAT REV GASTRO HEPAT, V16, P35, DOI 10.1038/s41575-018-0061-2