Potential of [C-11](R)-PK11195 PET Imaging for Evaluating Tumor Inflammation: A Murine Mammary Tumor Model
Carregando...
Citações na Scopus
1
Tipo de produção
article
Data de publicação
2022
Título da Revista
ISSN da Revista
Título do Volume
Editora
MDPI
Citação
PHARMACEUTICS, v.14, n.12, article ID 2715, 14p, 2022
Resumo
Background: Breast tumor inflammation is an immunological process that occurs mainly by mediation of Tumor-Associated Macrophages (TAM). Aiming for a specific measurement of tumor inflammation, the current study evaluated the potential of Positron Emission Tomography (PET) imaging with [C-11](R)-PK11195 to evaluate tumor inflammation in a mammary tumor animal model. Methods: Female Balb/C mice were inoculated with 4T1 cells. The PET imaging with [C-11](R)-PK11195 and [F-18]FDG was acquired 3 days, 1 week, and 2 weeks after cell inoculation. Results: The [C-11](R)-PK11195 tumor uptake increased from 3 days to 1 week, and decreased at 2 weeks after cell inoculation, as opposed to the [F-18]FDG uptake, which showed a slight decrease in uptake at 1 week and increased uptake at 2 weeks. In the control group, no significant differences occurred in tracer uptake over time. Tumor uptake of both radiopharmaceuticals is more expressed in tumor edge regions, with greater intensity at 2 weeks, as demonstrated by [C-11](R)-PK11195 autoradiography and immunofluorescence with TSPO antibodies and CD86 pro-inflammatory phenotype. Conclusion: The [C-11](R)-PK11195 was able to identify heterogeneous tumor inflammation in a murine model of breast cancer and the uptake varied according to tumor size. Together with the glycolytic marker [F-18]FDG, molecular imaging with [C-11](R)-PK11195 may provide a better characterization of inflammatory responses in cancer.
Palavras-chave
[C-11](R)-PK11195, TSPO, macrophages, positron emission tomography, breast cancer, inflammation
Referências
- Alcantara D, 2014, FRONT CHEM, V2, DOI 10.3389/fchem.2014.00112
- Ashton TM, 2018, CLIN CANCER RES, V24, P2482, DOI 10.1158/1078-0432.CCR-17-3070
- Bhoola NH, 2018, INT J MOL SCI, V19, DOI 10.3390/ijms19082176
- Bogdanovic RM, 2014, NEUROPHARMACOLOGY, V85, P104, DOI 10.1016/j.neuropharm.2014.05.002
- BRAESTRUP C, 1977, P NATL ACAD SCI USA, V74, P3805, DOI 10.1073/pnas.74.9.3805
- Chauveau F, 2008, EUR J NUCL MED MOL I, V35, P2304, DOI 10.1007/s00259-008-0908-9
- Faria DD, 2014, J NEUROIMMUNE PHARM, V9, P468, DOI 10.1007/s11481-014-9544-2
- Gaemperli O, 2012, EUR HEART J, V33, P1902, DOI 10.1093/eurheartj/ehr367
- Gao ZW, 2021, J PHARMACOL SCI, V145, P115, DOI 10.1016/j.jphs.2020.10.004
- Gavish M, 1999, PHARMACOL REV, V51, P629
- Hasnain Nimra, 2020, J Pak Med Assoc, V70, P2291
- Kang Y, 2018, PLOS ONE, V13, DOI 10.1371/journal.pone.0201289
- Kang YN, 2018, J NEUROIMAGING, V28, P496, DOI 10.1111/jon.12519
- LEFUR G, 1983, LIFE SCI, V32, P1839, DOI 10.1016/0024-3205(83)90062-0
- Li J, 2017, BIOCONJUGATE CHEM, V28, P1016, DOI 10.1021/acs.bioconjchem.6b00711
- Li XY, 2022, THER ADV MED ONCOL, V14, DOI 10.1177/17588359221076194
- Li YC, 2020, ACS APPL BIO MATER, V3, P4335, DOI 10.1021/acsabm.0c00368
- Liu TW, 2022, INT J MOL SCI, V23, DOI 10.3390/ijms23084148
- Madera L, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0133385
- Mantovani A, 2004, TRENDS IMMUNOL, V25, P677, DOI 10.1016/j.it.2004.09.015
- Najafi M, 2019, J CELL BIOCHEM, V120, P2756, DOI 10.1002/jcb.27646
- Oishi Y, 2018, INT IMMUNOL, V30, P511, DOI 10.1093/intimm/dxy054
- Passamonti L, 2018, NEUROLOGY, V90, pE1989, DOI 10.1212/WNL.0000000000005610
- Viana CTR, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0130809
- Serhan CN, 2011, CURR TOP MED CHEM, V11, P629
- Shoshan-Barmatz V, 2010, MOL ASPECTS MED, V31, P227, DOI 10.1016/j.mam.2010.03.002
- Singh N, 2019, ANN AFR MED, V18, P121, DOI 10.4103/aam.aam_56_18
- Su ZJ, 2013, EUR J NUCL MED MOL I, V40, P1406, DOI 10.1007/s00259-013-2447-2
- Sucksdorff M, 2017, J NUCL MED, V58, P1646, DOI 10.2967/jnumed.116.183020
- Tortelli TC, 2021, AGING-US, V13, P21914, DOI 10.18632/aging.203528
- Waterfield JD, 1999, RHEUMATOLOGY, V38, P1068, DOI 10.1093/rheumatology/38.11.1068
- Wu CX, 2014, THERANOSTICS, V4, P546, DOI 10.7150/thno.8159
- Wu XT, 2013, PLOS ONE, V8, DOI 10.1371/journal.pone.0071258
- Zinnhardt B, 2020, NEURO-ONCOLOGY, V22, P1030, DOI 10.1093/neuonc/noaa023
Coleções
Artigos e Materiais de Revistas Científicas - FM/Outros
Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/43
Carregar mais Artigos e Materiais de Revistas Científicas - FM/MDR
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/InRad
Artigos e Materiais de Revistas Científicas - LIM/24
Artigos e Materiais de Revistas Científicas - LIM/43