Structural Brain Changes in First-Episode Schizophrenia: A 4-5 Year Follow-Up Study Using MRI

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSCHALFELBERGER, Maristela S.
dc.contributor.authorROSA, Pedro G. P.
dc.contributor.authorDURAN, Fabio L. S.
dc.contributor.authorMENEZES, Paulo R.
dc.contributor.authorSCAZUFCA, Marcia
dc.contributor.authorMURRAY, Robin M.
dc.contributor.authorBUSATTO, Geraldo F.
dc.date.accessioned2013-10-11T21:25:01Z
dc.date.available2013-10-11T21:25:01Z
dc.date.issued2012
dc.description.abstractBackground: The presence of progressive structural brain changes over the first years of disease in first-episode schizophrenia (FES) patients is still controversial. The supposed progression of brain abnormalities in these patients may be associated with outcome and with antipsychotic exposure. Methods: Longitudinal population-based study performed in São Paulo - Brazil. Longitudinal analysis of GM matter volume using SPM was performed in 32 FES and 34 controls 4-5 years after baseline. Outcome measures were assessed by clinical course of symptoms (DSM-IV) and by global functioning (GAF scores). Results: FES did not differ from controls regarding GM changes over time, but those that remained psychotic and had lower global functioning over the follow-up period had GM concentration reduction in the left insula and in the left superior temporal gyrus in comparison to controls. Medication status had no effect on GM volumetric changes. Conclusions: Our findings suggest that a poor outcome, with chronic symptoms and a poor global functioning over 4-5 years after the first episode of psychosis is associated with brain abnormalities progression in brain regions which showed GM reduction at baseline (Schaufelberger et al, 2007). These results suggest that the progressive hypothesis in schizophrenia is probably not valid to all subjects that suffer from this illness.
dc.description.conferencedateMAY 03-05, 2012
dc.description.conferencelocalPhiladelphia - PA, EUA
dc.description.conferencename67th Annual Scientific Convention and Meeting of the Society-of-Biological-Psychiatry
dc.description.indexMEDLINE
dc.description.sponsorshipWellcome Trust
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.identifier.citationBIOLOGICAL PSYCHIATRY, v.71, n.8, suppl.S, p.258S-258S, 2012
dc.identifier.issn0006-3223
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2959
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofBiological Psychiatry
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectSchizophrenia
dc.subjectBipolar Disorder
dc.subjectNeuroimaging
dc.subjectOutcome
dc.subjectCognition
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleStructural Brain Changes in First-Episode Schizophrenia: A 4-5 Year Follow-Up Study Using MRI
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.affiliation.countryInglaterra
hcfmusp.affiliation.countryisogb
hcfmusp.author.externalMURRAY, Robin M.:Kings Coll London, Inst Psychiat, London WC2R 2LS, England
hcfmusp.contributor.author-fmusphcMARISTELA SCHAUFELBERGER SPANGHERO
hcfmusp.contributor.author-fmusphcPEDRO GOMES PENTEADO ROSA
hcfmusp.contributor.author-fmusphcFABIO LUIS DE SOUZA DURAN
hcfmusp.contributor.author-fmusphcPAULO ROSSI MENEZES
hcfmusp.contributor.author-fmusphcMARCIA SCAZUFCA
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.description.beginpage258S
hcfmusp.description.endpage258S
hcfmusp.description.issue8
hcfmusp.description.issuesuppl S
hcfmusp.description.volume71
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000302466001130
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
hcfmusp.remissive.sponsorshipFAPESP
hcfmusp.remissive.sponsorshipWellcome Trust
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