Catch-up growth in patients with congenital or acquired growth hormone deficiency after GH replacement: Clinical features and hypothalamic-pituitary imaging

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCARVALHO, L. R.
dc.contributor.authorARNHOLD, I. J. P.
dc.contributor.authorMENDONCA, B. B.
dc.contributor.authorCOSTALONGA, E. F.
dc.contributor.authorOTTO, A. P.
dc.contributor.authorLEITE, C. Da Costa
dc.contributor.authorLUCATO, L. T.
dc.contributor.authorPERUCHI, M. M.
dc.date.accessioned2023-02-09T19:56:13Z
dc.date.available2023-02-09T19:56:13Z
dc.date.issued2012
dc.description.abstractHypothalamic and pituitary disorders usually impair statural growth. These disorders may be either congenital or acquired with differences in clinical presentation. Growth failure is mainly related to growth hormone deficiency (GHD) that can be accompanied by other pituitary hormone deficiencies. The onset of clinical features may be insidious and unnoticed for years or decades. Therefore, it is important to periodically assess auxologic data such as height, growth velocity, bone maturation and evaluate hormonal levels related to hypothalamic-pituitary axis in these patients. Magnetic resonance imaging (MRI) greatly improved the study of central nervous system (CNS) disorders including the hypothalamic-pituitary region. Currently, it is an essential tool in the definition of the etiology of GHD. It can detect tumors that may require surgical intervention, and also provide insights into other causes of GHD. Catch up growth of congenital disorders is essentially dependent on hormone replacement. Even with an initial diagnosis of IGHD, attention should be given to the risk of the development of multiple pituitary hormone deficiencies. In addition to the hormonal deficiencies due to the acquired disorder themselves; their treatment (surgery, irradiation, chemotherapy) often leads to combined pituitary deficits. Growth responsiveness to rhGH has safety aspects of treatment which deserve additional discussion. © Springer Science+Business Media, LLC 2012. All rights reserved.
dc.identifier.citationCarvalho, L. R.; Arnhold, I. J. P.; Mendonca, B. B.; Costalonga, E. F.; Otto, A. P.; Da Costa Leite, C.; Lucato, L. T.; Peruchi, M. M.. Catch-up growth in patients with congenital or acquired growth hormone deficiency after GH replacement: Clinical features and hypothalamic-pituitary imaging. In: . HANDBOOK OF GROWTH AND GROWTH MONITORING IN HEALTH AND DISEASE: SPRINGER NEW YORK, 2012. p.963-985.
dc.identifier.doi10.1007/978-1-4419-1795-9_57
dc.identifier.isbn9781441917959; 9781441917942
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/51062
dc.language.isoeng
dc.publisherSPRINGER NEW YORK
dc.relation.ispartofHANDBOOK OF GROWTH AND GROWTH MONITORING IN HEALTH AND DISEASE
dc.rightsrestrictedAccess
dc.rights.holderCopyright SPRINGER NEW YORK
dc.titleCatch-up growth in patients with congenital or acquired growth hormone deficiency after GH replacement: Clinical features and hypothalamic-pituitary imaging
dc.typebookPart
dc.type.categorybook chapter
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalPERUCHI, M. M.:Division of Endocrinology, Hospital das Clinicas, University of São Paulo Medical School, São Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcLUCIANI RENATA SILVEIRA DE CARVALHO
hcfmusp.contributor.author-fmusphcIVO JORGE PRADO ARNHOLD
hcfmusp.contributor.author-fmusphcBERENICE BILHARINHO DE MENDONCA
hcfmusp.contributor.author-fmusphcEVERLAYNY FIOROT COSTALONGA
hcfmusp.contributor.author-fmusphcALINE PEDROSA OTTO
hcfmusp.contributor.author-fmusphcCLAUDIA DA COSTA LEITE
hcfmusp.contributor.author-fmusphcLEANDRO TAVARES LUCATO
hcfmusp.description.beginpage963
hcfmusp.description.endpage985
hcfmusp.origemSCOPUS
hcfmusp.origem.scopus2-s2.0-85025613640
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