Voiding Dysfunction in Patients With Neuromyelitis Optica Spectrum Disorders

Imagem de Miniatura
Arquivos
art_CARVALHO_Voiding_Dysfunction_in_Patients_With_Neuromyelitis_Optica_Spectrum_2016.PDF (88.57 KB)
Citações na Scopus
18
Tipo de produção
article
Data de publicação
2016
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
WILEY-BLACKWELL
Autores
Citação
NEUROUROLOGY AND URODYNAMICS, v.35, n.1, p.39-43, 2016
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Aims: We assessed the lower urinary tract symptoms (LUTS) and urodynamic findings in patients with neuromyelitis optica spectrum disorders (NMO-SD), a recently defined neurological disease. Methods: We prospectively evaluated seven men and 23 women (mean age 41.1 +/- 13.5 years) with an established diagnosis of NMO-SD who were invited to participate irrespective of the presence of LUTS. Neurological evaluation was assessed with the Expanded Disability Status Scale (EDSS) and LUTS were evaluated with the Overactive Bladder questionnaire (OAB-V8) and the International Prostate Symptom Score (I-PSS). All patients underwent videourodynamics, transabdominal urinary tract sonography, urine culture, and serum creatinine levels. Results: The mean time of disease duration was 33.8 +/- 30.8 months. Neurological evaluation showed a mean EDSS score of 5.3 +/- 1.8. The most frequent videourodynamic findings were detrusor-sphincter dyssynergia (DSD) and detrusor overactivity (DO) in 11 (36.6%) patients, DSD without DO in seven (23.3%) and DO without DSD in six (20.0%) patients. Voiding dysfunction assessed by I-PSS and OAB-V8 increased with the degree of neurological impairment (P = 0.018; r = 0.42 and P = 0.006; r = 0.48 respectively). Patients with DSD had higher I-PSS (18.5 +/- 11.4 vs 7.0 +/- 9.2; P = 0.029) and OAB-V8 scores (22.8 +/- 15.8vs 9.1 +/- 7.8; P = 0.008), and worse neurological impairment (mean EDSS 5.9 +/- 1.8 vs 4.5 +/- 1.5; P = 0.027). Conclusions: Most patients with NMO-SD have LUTS and voiding dysfunction, with DSD and DO as the main urodynamic findings. The severity of the neurological disease is a predictive factor for the occurrence of voiding dysfunction and detrusor-sphincter dyssynergia. (C) 2014 Wiley Periodicals, Inc.
Palavras-chave
bladder dysfunction, demyelinating diseases, lower uinary tract symptoms, neuromyelitis optica, urodynamics
URI
https://observatorio.fm.usp.br/handle/OPI/13946
Referências
  1. Adoni T, 2008, ARQ NEURO-PSIQUIAT, V66, P295, DOI 10.1590/S0004-282X2008000300001
  2. Litwiller SE, 1999, J UROLOGY, V161, P743, DOI 10.1016/S0022-5347(01)61760-9
  3. Ciancio SJ, 2001, UROLOGY, V57, P239, DOI 10.1016/S0090-4295(00)01070-0
  4. KURTZKE JF, 1983, NEUROLOGY, V33, P1444
  5. Weinshenker BG, 2006, ANN NEUROL, V59, P566, DOI 10.1002/ana.20770
  6. Argyriou AA, 2008, ACTA NEUROL SCAND, V118, P209, DOI 10.1111/j.1600-0404.2008.01002.x
  7. Collongues N, 2010, NEUROLOGY, V74, P736, DOI 10.1212/WNL.0b013e3181d31e35
  8. Lennon VA, 2004, LANCET, V364, P2106, DOI 10.1016/S0140-6736(04)17551-X
  9. Wingerchuk DM, 2007, LANCET NEUROL, V6, P805, DOI 10.1016/S1474-4422(07)70216-8
  10. Acquadro C, 2006, UROLOGY, V67, P536, DOI 10.1016/j.urology.2005.09.035
  11. Saiz A, 2007, J NEUROL, V254, P1233, DOI 10.1007/s00415-007-0509-8
  12. Abrams P, 2002, NEUROUROL URODYNAM, V21, P167, DOI 10.1002/nau.10052
  13. Lemack GE, 2005, UROLOGY, V65, P854, DOI 10.1016/j.urology.2004.11.038
  14. Araki I, 2002, J NEUROL, V249, P1010, DOI 10.1007/s00415-002-0775-4
  15. Dellavance A, 2012, EUR J NEUROL, V19, P248, DOI 10.1111/j.1468-1331.2011.03479.x
  16. Papeix C, 2007, MULT SCLER, V13, P256, DOI 10.1177/1352458506070732
  17. Bichuetti DB, 2009, MULT SCLER, V15, P613, DOI 10.1177/1352458508101935
  18. Wingerchuk DM, 2006, NEUROLOGY, V66, P1485, DOI 10.1212/01.wnl.0000216139.44259.74
  19. Kim SH, 2010, J NEUROL, V257, P920, DOI 10.1007/s00415-009-5438-2
  20. KOLDEWIJN EL, 1995, J UROLOGY, V154, P169, DOI 10.1016/S0022-5347(01)67258-6
  21. Wingerchuk DM, 2008, CURR TREAT OPTION N, V10, P55, DOI 10.1007/s11940-008-0007-z
  22. BARRY MJ, 1992, J UROLOGY, V148, P1549
  23. BEMELMANS BLH, 1991, J UROLOGY, V145, P1219
  24. Fugl-Meyer AR, 1991, CLIN REHABIL, V5, P25, DOI 10.1177/026921559100500105
  25. Jiao YJ, 2013, NEUROLOGY, V81, P1197, DOI 10.1212/WNL.0b013e3182a6cb5c

Coleções
Artigos e Materiais de Revistas Científicas - FM/MNE
Artigos e Materiais de Revistas Científicas - FM/MCG
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IMREA
Artigos e Materiais de Revistas Científicas - HC/IOT
Artigos e Materiais de Revistas Científicas - LIM/45
Carregar mais