Risk of thrombosis and mortality in inflammatory bowel disease

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorANDRADE, Adriana R.
dc.contributor.authorBARROS, Luisa L.
dc.contributor.authorAZEVEDO, Matheus F. C.
dc.contributor.authorCARLOS, Alexandre S.
dc.contributor.authorDAMIAO, Aderson O. M. C.
dc.contributor.authorSIPAHI, Aytan M.
dc.contributor.authorLEITE, Andre Z. A.
dc.date.accessioned2018-11-21T17:09:25Z
dc.date.available2018-11-21T17:09:25Z
dc.date.issued2018
dc.description.abstractObjectives: Patients with inflammatory bowel disease have a higher risk of thrombosis, which is associated with a higher morbidity and mortality. Most data about VTE are related to hospitalized patients with active disease, but several cases happen in the outpatient setting, and are not covered by current prophylaxis recommendation. As the knowledge of VTE in outpatients is still poor, the aim of this study is to evaluate the risk, clinical data and mortality of thrombosis in patients followed in our center, comparing our findings with the current prophylaxis recommendation. Methods: The medical electronic chart of 1093 inflammatory bowel disease patients and their image exams were actively searched for words related to thrombosis, followed by charts reviewed to collect information about the event and data regarding clinical settings and thrombosis profile. Results: Overall, 654 Crohn's and 439 Colitis patients were included. Thrombosis prevalence was 5.1%, and mortality rate was higher in patients who had suffered thrombosis (10.71% vs. 1.45%, OR 8.0). Half of them developed thrombosis in the outpatient setting, 52% of these had disease activity, 17% had recent hospitalization, and 10% had previous thrombosis. In 27% of cases, diagnosis was done by routine image exams, with no clinical symptoms or previous history of thrombosis. None of them had used thromboprophylaxis. However, a great majority of patients who had thrombosis during hospitalization used heparin prophylaxis. Conclusion: Inflammatory bowel disease patients who develop thrombosis have an increased mortality risk. A significant proportion of the events happened in patients without a clear thromboprophylaxis recommendation or in those receiving heparin prophylaxis.
dc.description.indexPubMed
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [2015/06196-0]
dc.identifier.citationCLINICAL AND TRANSLATIONAL GASTROENTEROLOGY, v.9, article ID 142, 7p, 2018
dc.identifier.doi10.1038/s41424-018-0013-8
dc.identifier.issn2155-384X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/29675
dc.language.isoeng
dc.publisherNATURE PUBLISHING GROUP
dc.relation.ispartofClinical and Translational Gastroenterology
dc.rightsopenAccess
dc.rights.holderCopyright NATURE PUBLISHING GROUP
dc.subject.othervenous thromboembolism
dc.subject.othercrohns-disease
dc.subject.otherprevention
dc.subject.othermanagement
dc.subject.otherconsensus
dc.subject.wosGastroenterology & Hepatology
dc.titleRisk of thrombosis and mortality in inflammatory bowel disease
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.citation.scopus49
hcfmusp.contributor.author-fmusphcADRIANA RIBAS ANDRADE
hcfmusp.contributor.author-fmusphcLUISA LEITE BARROS
hcfmusp.contributor.author-fmusphcMATHEUS FREITAS CARDOSO DE AZEVEDO
hcfmusp.contributor.author-fmusphcALEXANDRE DE SOUSA CARLOS
hcfmusp.contributor.author-fmusphcADERSON OMAR MOURAO CINTRA DAMIAO
hcfmusp.contributor.author-fmusphcAYTAN MIRANDA SIPAHI
hcfmusp.contributor.author-fmusphcANDRE ZONETTI DE ARRUDA LEITE
hcfmusp.description.articlenumber142
hcfmusp.description.volume9
hcfmusp.origemWOS
hcfmusp.origem.pubmed29618721
hcfmusp.origem.scopus2-s2.0-85045131913
hcfmusp.origem.wosWOS:000447528100001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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hcfmusp.scopus.lastupdate2024-05-10
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Artigos e Materiais de Revistas Científicas - LIM/07
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