Effect of Low-Dose Progesterone on Glycemic Metabolism, Morphology and Function of Adipose Tissue and Pancreatic Islets in Diet-Induced Obese Female Mice

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSANTOS, Matheus P.
dc.contributor.authorCAUDURO, Leonardo F. R.
dc.contributor.authorFERREIRA, Marilia Marcondes
dc.contributor.authorMARTUCCI, Luiz Felipe
dc.contributor.authorVECCHIATTO, Bruno
dc.contributor.authorVILAS-BOAS, Eloisa Aparecida
dc.contributor.authorAMERICO, Anna Laura V.
dc.contributor.authorPEREIRA, Renata O.
dc.contributor.authorROGERO, Marcelo Macedo
dc.contributor.authorFIORINO, Patricia
dc.contributor.authorEVANGELISTA, Fabiana S.
dc.contributor.authorAZEVEDO-MARTINS, Anna Karenina
dc.date.accessioned2024-02-15T14:53:37Z
dc.date.available2024-02-15T14:53:37Z
dc.date.issued2023
dc.description.abstractBackground: Obesity is a worldwide concern due to its global rapid expansion and remarkable impact on individual's health by predisposing to several other diseases. About twice as many women as men suffer from severe obesity and, in fact, there are stages in a woman's life when weight gain and adiposity can result in greater damage to health. For example, obesity triples the chance of a woman developing gestational diabetes. Many hormones promote the metabolic adaptations of pregnancy, including progesterone, whose role in female obesity is still not well known despite being involved in many physiological and pathological processes. Methods: Here we investigated whether progesterone treatment at low dose can worsen the glucose metabolism and the morpho functional aspects of adipose tissue and pancreas in obese females. Mice were assigned into four groups: normocaloric diet control (NO-CO), high-fat and -fructose diet control (HFF-CO), normocaloric diet plus progesterone (NO-PG) and high-fat and -fructose diet plus progesterone (HFF-PG) for 10 weeks. Infusion of progesterone (0.25 mg/kg/day) was done by osmotic minipump in the last 21 days of protocol. Results: Animals fed a hypercaloric diet exhibited obesity with increased body weight (p < 0.0001), adipocyte hypertrophy (p < 0.0001), hyperglycemia (p = 0.03), and glucose intolerance (p = 0.001). HFF-CO and HFF-PG groups showed lower adiponectin concentration (p < 0.0001) and glucose-stimulated insulin secretion (p = 0.03), without differences in islet size. Progesterone attenuated glucose intolerance in the HFFPG group (p = 0.03), however, did not change morphology or endocrine function of adipose tissue and pancreatic islets. Conclusions: Taken together, our results showed that low dose of progesterone does not worsen the effects of hypercaloric diet in glycemic metabolism, morphology and function of adipose tissue and pancreatic islets in female animals. These results may improve the understanding of the mechanisms underlying the pathogenesis of obesity in women and eventually open new avenues for therapeutic strategies and better comprehension of the interactions between progesterone effects and obesity.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.description.sponsorshipSo Paulo Research Foundation (FAPESP) [18/22361- 9]
dc.identifier.citationFRONTIERS IN BIOSCIENCE-LANDMARK, v.28, n.11, article ID 312, 14p, 2023
dc.identifier.doi10.31083/j.fbl2811312
dc.identifier.eissn2768-6698
dc.identifier.issn2768-6701
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58058
dc.language.isoeng
dc.publisherIMR PRESSeng
dc.relation.ispartofFrontiers in Bioscience-Landmark
dc.rightsopenAccesseng
dc.rights.holderCopyright IMR PRESSeng
dc.subjectobesityeng
dc.subjecthypercaloric dieteng
dc.subjectfemaleseng
dc.subjectprogesteroneeng
dc.subjectadipose tissueeng
dc.subjectpancreatic isletseng
dc.subject.otheracylation-stimulating proteineng
dc.subject.otherinsulin-resistanceeng
dc.subject.otherlangerhanseng
dc.subject.otherestradioleng
dc.subject.otherpregnancyeng
dc.subject.othercomplicationseng
dc.subject.othermechanismseng
dc.subject.otherinsightseng
dc.subject.othernumbereng
dc.subject.otherratseng
dc.subject.wosBiochemistry & Molecular Biologyeng
dc.subject.wosCell Biologyeng
dc.titleEffect of Low-Dose Progesterone on Glycemic Metabolism, Morphology and Function of Adipose Tissue and Pancreatic Islets in Diet-Induced Obese Female Miceeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalSANTOS, Matheus P.:Univ Sao Paulo, Sch Arts Sci & Humanities, Biosci Studies Grp, BR-03828000 Sao Paulo, Brazil
hcfmusp.author.externalCAUDURO, Leonardo F. R.:Univ Sao Paulo, Sch Arts Sci & Humanities, Biosci Studies Grp, BR-03828000 Sao Paulo, Brazil
hcfmusp.author.externalFERREIRA, Marilia Marcondes:Univ Sao Paulo, Sch Arts Sci & Humanities, Sport Biol Res Grp, BR-03828000 Sao Paulo, Brazil
hcfmusp.author.externalVILAS-BOAS, Eloisa Aparecida:Univ Sao Paulo, Inst Quim, BR-05599070 Sao Paulo, Brazil
hcfmusp.author.externalPEREIRA, Renata O.:Univ Fed Sao Paulo, Dept Med, Translat Med Div, BR-04023062 Sao Paulo, Brazil
hcfmusp.author.externalROGERO, Marcelo Macedo:Univ Sao Paulo, Sch Publ Hlth, Nutr Genom & Inflammat Lab, BR-01246904 Sao Paulo, Brazil
hcfmusp.author.externalFIORINO, Patricia:Mackenzie Presbyterian Univ Sao Paulo, Hlth & Biol Sci Ctr, Renal Cardiovasc & Metab Physiopharmacol Lab, Sao Paulo, Brazil
hcfmusp.author.externalEVANGELISTA, Fabiana S.:Univ Sao Paulo, Sch Arts Sci & Humanities, Sport Biol Res Grp, BR-03828000 Sao Paulo, Brazil
hcfmusp.author.externalAZEVEDO-MARTINS, Anna Karenina:Univ Sao Paulo, Sch Arts Sci & Humanities, Biosci Studies Grp, BR-03828000 Sao Paulo, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcLUIZ FELIPE MARTUCCI
hcfmusp.contributor.author-fmusphcBRUNO VECCHIATTO
hcfmusp.contributor.author-fmusphcANNA LAURA VIACAVA AMERICO
hcfmusp.description.articlenumber312
hcfmusp.description.issue11
hcfmusp.description.volume28
hcfmusp.origemWOS
hcfmusp.origem.pubmed38062821
hcfmusp.origem.scopus2-s2.0-85179646191
hcfmusp.origem.wosWOS:001124039900013
hcfmusp.publisher.cityROBINSONeng
hcfmusp.publisher.countrySINGAPOREeng
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