Nonalcoholic steatohepatitis and hepatocellular carcinoma: Brazilian survey

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCOTRIM, Helma P.
dc.contributor.authorOLIVEIRA, Claudia P.
dc.contributor.authorCOELHO, Henrique Sergio M.
dc.contributor.authorALVARES-DA-SILVA, Mario R.
dc.contributor.authorNABUCO, Leticia
dc.contributor.authorPARISE, Edison Roberto
dc.contributor.authorIVANTES, Claudia
dc.contributor.authorMARTINELLI, Ana L. C.
dc.contributor.authorGALIZZI-FILHO, Joao
dc.contributor.authorCARRILHO, Flair J.
dc.contributor.groupauthorSBH Brazilian HCC-NASH Survey
dc.date.accessioned2016-12-20T16:37:47Z
dc.date.available2016-12-20T16:37:47Z
dc.date.issued2016
dc.description.abstractOBJECTIVE: The majority of cases of hepatocellular carcinoma have been reported in individuals with cirrhosis due to chronic viral hepatitis and alcoholism, but recently, the prevalence has become increasingly related to nonalcoholic steatohepatitis around the world. The study aimed to evaluate the clinical and histophatological characteristics of hepatocellular carcinoma in Brazilians' patients with nonalcoholic steatohepatitis at the present time. METHODS: Members of the Brazilian Society of Hepatology were invited to complete a survey regarding patients with hepatocellular carcinoma related to nonalcoholic steatohepatitis. Patients with a history of alcohol intake (420 g/day) and other liver diseases were excluded. Hepatocellular carcinoma diagnosis was performed by liver biopsy or imaging methods according to the American Association for the Study of Liver Diseases' 2011 guidelines. RESULTS: The survey included 110 patients with a diagnosis of hepatocellular carcinoma and nonalcoholic fatty liver disease from nine hepatology units in six Brazilian states (Bahia, Minas Gerais, Rio de Janeiro, Sao Paulo, Parana and Rio Grande do Sul). The mean age was 67 +/- 11 years old, and 65.5% were male. Obesity was observed in 52.7% of the cases; diabetes, in 73.6%; dyslipidemia, in 41.0%; arterial hypertension, in 60%; and metabolic syndrome, in 57.2%. Steatohepatitis without fibrosis was observed in 3.8% of cases; steatohepatitis with fibrosis (grades 1-3), in 27%; and cirrhosis, in 61.5%. Histological diagnosis of hepatocellular carcinoma was performed in 47.2% of the patients, with hepatocellular carcinoma without cirrhosis accounting for 7.7%. In total, 58 patients with cirrhosis had their diagnosis by ultrasound confirmed by computed tomography or magnetic resonance imaging. Of these, 55% had 1 nodule; 17%, 2 nodules; and 28%, >= 3 nodules. CONCLUSIONS: Nonalcoholic steatohepatitis is a relevant risk factor associated with hepatocellular carcinoma in patients with and without cirrhosis in Brazil. In this survey, hepatocellular carcinoma was observed in elevated numbers of patients with steatohepatitis without cirrhosis.
dc.description.indexMEDLINE
dc.description.sponsorshipSociedade Brasileira de Hepatologia/SBH (Brazilian Society of Hepatology)
dc.identifier.citationCLINICS, v.71, n.5, p.281-284, 2016
dc.identifier.doi10.6061/clinics/2016(05)07
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/17074
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULO
dc.relation.ispartofClinics
dc.rightsopenAccess
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULO
dc.subjectNon-alcoholic Fatty Liver Disease
dc.subjectNonalcoholic Steatohepatitis
dc.subjectHepatocellular Carcinoma
dc.subjectFatty Liver
dc.subject.othernatural-history
dc.subject.othermanagement
dc.subject.otherdna
dc.subject.wosMedicine, General & Internal
dc.titleNonalcoholic steatohepatitis and hepatocellular carcinoma: Brazilian survey
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCOTRIM, Helma P.:Univ Fed Bahia, Dept Med, Serv Gastrohepatol, Salvador, BA, Brazil
hcfmusp.author.externalCOELHO, Henrique Sergio M.:Univ Fed Rio de Janeiro, Dept Clin Med, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalALVARES-DA-SILVA, Mario R.:Univ Fed Rio Grande do Sul, Hosp Clin Porto Alegre, Dept Med Interna, Serv Gastroenterol, Porto Alegre, RS, Brazil
hcfmusp.author.externalNABUCO, Leticia:Hosp Fed Servidores Estado, Serv Clin Med, Setor Hepatol, Rio De Janeiro, RJ, Brazil
hcfmusp.author.externalIVANTES, Claudia:Hosp Nossa Senhora Gracas, Serv Gastroenterol Hepatol Transplante Hepat, Curitiba, PR, Brazil
hcfmusp.author.externalMARTINELLI, Ana L. C.:Univ Sao Paulo, Fac Med Ribeirao Preto, Dept Clin Med, Div Gastroenterol, Ribeirao Preto, SP, Brazil
hcfmusp.author.externalGALIZZI-FILHO, Joao:Univ Fed Minas Gerais, Dept Clin Med, Belo Horizonte, MG, Brazil
hcfmusp.citation.scopus20
hcfmusp.contributor.author-fmusphcCLAUDIA PINTO MARQUES SOUZA DE OLIVEIRA
hcfmusp.contributor.author-fmusphcEDISON ROBERTO PARISE
hcfmusp.contributor.author-fmusphcFLAIR JOSE CARRILHO
hcfmusp.description.beginpage281
hcfmusp.description.endpage284
hcfmusp.description.issue5
hcfmusp.description.volume71
hcfmusp.origemWOS
hcfmusp.origem.pubmed27276398
hcfmusp.origem.scieloSCIELO:S1807-59322016000500281
hcfmusp.origem.scopus2-s2.0-84973345566
hcfmusp.origem.wosWOS:000379039100007
hcfmusp.publisher.citySAO PAULO
hcfmusp.publisher.countryBRAZIL
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