Increased Lactate Levels During Depressive Episodes and Reversal Effects by Lithium Monotherapy in Subjects with Bipolar Disorder

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMACHADO-VIEIRA, Rodrigo
dc.contributor.authorZANETTI, Marcus V.
dc.contributor.authorOTADUY, Maria C. G.
dc.contributor.authorSOUSA, Rafael T. de
dc.contributor.authorCOSTA, Alana C.
dc.contributor.authorCHAIM, Tiffany M.
dc.contributor.authorLEITE, Claudia C.
dc.contributor.authorBUSATTO, Geraldo F.
dc.contributor.authorGATTAZ, Wagner F.
dc.date.accessioned2013-10-11T21:18:20Z
dc.date.available2013-10-11T21:18:20Z
dc.date.issued2013
dc.description.abstractBackground: Altered energy metabolism has been widely described in Bipolar Disorder (BD). However, brain lactate levels have been only evaluated in few studies with heterogeneous samples using magnetic resonance spectroscopy (MRS). These findings support the presence of dysfunctional brain energy production as a central component in the pathophysiology of BD. However, no study to date has evaluated brain lactate levels specifically in bipolar depression or even the effects of lithium treatment in brain lactate levels in subjects with BD. Methods: Twenty-four BD individuals (up to 5 years of illness duration) presenting with an acute depressive episode underwent MRS at baseline and after 6 weeks of lithium therapy at therapeutic doses. Lactate levels were measures in the cingulated cortex (CC). Clinical assessment was performed weekly using the 21-item Hamilton Depression Rating Scale (HDRS) and the Young Mania Rating Scale (YMRS). A group of age and gender-matched healthy controls (n=18) was also studied. Results: BD patients exhibited increased brain lactate in the CC relative to healthy controls at baseline. A significant decrease in brain lactate levels was observed after 6 weeks of lithium treatment, and correlated with clinical response (reduction ≥ 50% in HDRS scores). Conclusions: Lithium treatment produces a significant decrease in brain lactate levels of acutely depressed BD patients. This suggests that the clinical efficacy of lithium is also associated with reduction in the shift from aerobic to anaerobic metabolism observed in BD.
dc.description.conferencedateMAY 16-18, 2013
dc.description.conferencelocalSan Francisco - CA, EUA
dc.description.conferencename68th Annual Scientific Meeting of the Society-of-Biological-Psychiatry
dc.description.indexMEDLINE
dc.identifier.citationBIOLOGICAL PSYCHIATRY, v.73, n.9, suppl.S, p.238S-238S, 2013
dc.identifier.issn0006-3223
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2829
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofBiological Psychiatry
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subjectbipolar disorder
dc.subjectdepression
dc.subjectlithium
dc.subjecttreatment
dc.subjectlactate
dc.subject.wosNeurosciences
dc.subject.wosPsychiatry
dc.titleIncreased Lactate Levels During Depressive Episodes and Reversal Effects by Lithium Monotherapy in Subjects with Bipolar Disorder
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalCOSTA, Alana C.:Univ Sao Paulo, Dept Psychiat, Mood Disorders Program, LIM27, Sao Paulo, Brazil
hcfmusp.contributor.author-fmusphcRODRIGO MACHADO VIEIRA
hcfmusp.contributor.author-fmusphcMARCUS VINICIUS ZANETTI
hcfmusp.contributor.author-fmusphcMARIA CONCEPCION GARCIA OTADUY
hcfmusp.contributor.author-fmusphcRAFAEL AUGUSTO TEIXEIRA DE SOUSA
hcfmusp.contributor.author-fmusphcTIFFANY MOUKBEL CHAIM AVANCINI
hcfmusp.contributor.author-fmusphcCLAUDIA DA COSTA LEITE
hcfmusp.contributor.author-fmusphcGERALDO BUSATTO FILHO
hcfmusp.contributor.author-fmusphcWAGNER FARID GATTAZ
hcfmusp.description.beginpage238S
hcfmusp.description.endpage238S
hcfmusp.description.issue9
hcfmusp.description.issuesuppl S
hcfmusp.description.volume73
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000318671801054
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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Comunicações em Eventos - LIM/27
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