Differential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorCHANG, Claudia Veiga
dc.contributor.authorARAUJO, Ricardo Vieira
dc.contributor.authorCIRQUEIRA, Cinthya Santos
dc.contributor.authorCANI, Carolina Maria Gomes
dc.contributor.authorMATUSHITA, Hamilton
dc.contributor.authorCESCATO, Valter Angelo Sperling
dc.contributor.authorFRAGOSO, Maria Candida Barisson Villares
dc.contributor.authorBRONSTEIN, Marcello Delano
dc.contributor.authorZERBINI, Maria Claudia Nogueira
dc.contributor.authorMENDONCA, Berenice Bilharinho
dc.contributor.authorCARVALHO, Luciani Renata
dc.date.accessioned2017-02-16T12:47:57Z
dc.date.available2017-02-16T12:47:57Z
dc.date.issued2017
dc.description.abstractBackground/Aims: Although craniopharyngioma (CP) is histologically benign, it is a pituitary tumour that grows rapidly and often recurs. Adamantinomatous CP (ACP) was associated with an activating mutation in beta-catenin, and it has been postulated that pituitary stem cells might play a role in oncogenesis in human ACP. Stem cells have also been identified in pituitary adenoma. Our aim was to characterize the expression pattern of ABCG2, CD44, DLL4, NANOG, NOTCH2, POU5F1/OCT4, SOX2, and SOX9 stem cell markers in human ACP and pituitary adenoma. Methods and Results: We studied 33 patients (9 ACP and 24 adenoma) using real- time quantitative PCR (RT-qPCR) and immunohistochemistry. SOX9 was up-regulated in ACP, exhibiting positive immunostaining in the epithelium and stroma, with the highest expression in patients with recurrence. CD44 was overexpressed in ACP as confirmed by immunohistochemistry. SOX2 did not significantly differ among the tumour types. The RT-qPCR array showed an increased expression of MKI67, OCT4/POU5F1, and DLL4 in all tumours. NANOG was decreased in ACP. ABCG2 was down-regulated in most of the tumours. NOTCH2 was significantly decreased in the adenomas. Conclusion: Our results confirm the presence of stem cell markers in human pituitary tumours as well as the different expression patterns of ACP and adenoma. These findings suggest that ACP may originate from a more undifferentiated cell cluster. Additionally, SOX9 immunodetection in the stroma and the highest expression levels related to the relapse of patients suggest a contribution to the aggressive behaviour and high recurrence of this tumour type. (C) 2016 S. Karger AG, Basel.
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao Faculdade de Medicina of the University of Sao Paulo
dc.description.sponsorshipFAPESP [2011/03622-7]
dc.description.sponsorshipCapes/PNPD
dc.identifier.citationNEUROENDOCRINOLOGY, v.104, n.2, p.183-193, 2017
dc.identifier.doi10.1159/000446072
dc.identifier.eissn1423-0194
dc.identifier.issn0028-3835
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/18016
dc.language.isoeng
dc.publisherKARGER
dc.relation.ispartofNeuroendocrinology
dc.rightsrestrictedAccess
dc.rights.holderCopyright KARGER
dc.subjectStem cell markers
dc.subjectTumour
dc.subjectPituitary adenoma
dc.subjectCraniopharyngioma
dc.subject.otherbeta-catenin mutations
dc.subject.otherstem/progenitor cells
dc.subject.otherside population
dc.subject.othertumors
dc.subject.othercd44
dc.subject.othercancer
dc.subject.otherbenign
dc.subject.otherniche
dc.subject.otherviability
dc.subject.othergenes
dc.subject.wosEndocrinology & Metabolism
dc.subject.wosNeurosciences
dc.titleDifferential Expression of Stem Cell Markers in Human Adamantinomatous Craniopharyngioma and Pituitary Adenoma
dc.typearticle
dc.type.categoryoriginal article
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalARAUJO, Ricardo Vieira:FMUSP, Div Endocrinol, Lab Hormonios & Genet Mol LIM 42, Sao Paulo, SP, Brazil; Minist Ciencia Tecnol & Inovacao, Secretaria Polit & Programas Pesquisa & Desenvolv, Brasilia, DF, Brazil
hcfmusp.author.externalCIRQUEIRA, Cinthya Santos:FMUSP, Inst Adolfo Lutz, Ctr Patol, Nucleo Anat Patol, Sao Paulo, SP, Brazil
hcfmusp.author.externalCANI, Carolina Maria Gomes:FMUSP, Div Endocrinol, Lab Hormonios & Genet Mol LIM 42, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcCLAUDIA VEIGA CHANG
hcfmusp.contributor.author-fmusphcHAMILTON MATUSHITA
hcfmusp.contributor.author-fmusphcVALTER ANGELO SPERLING CESCATO
hcfmusp.contributor.author-fmusphcMARIA CANDIDA BARISSON VILLARES FRAGOSO
hcfmusp.contributor.author-fmusphcMARCELLO DELANO BRONSTEIN
hcfmusp.contributor.author-fmusphcMARIA CLAUDIA NOGUEIRA ZERBINI
hcfmusp.contributor.author-fmusphcBERENICE BILHARINHO DE MENDONCA
hcfmusp.contributor.author-fmusphcLUCIANI RENATA SILVEIRA DE CARVALHO
hcfmusp.description.beginpage183
hcfmusp.description.endpage193
hcfmusp.description.issue2
hcfmusp.description.volume104
hcfmusp.origemWOS
hcfmusp.origem.pubmed27161333
hcfmusp.origem.scopus2-s2.0-84967188805
hcfmusp.origem.wosWOS:000390556400008
hcfmusp.publisher.cityBASEL
hcfmusp.publisher.countrySWITZERLAND
hcfmusp.relation.referenceAndoniadou CL, 2012, ACTA NEUROPATHOL, V124, P259, DOI 10.1007/s00401-012-0957-9
hcfmusp.relation.referenceAndoniadou CL, 2013, CELL STEM CELL, V13, P433, DOI 10.1016/j.stem.2013.07.004
hcfmusp.relation.referenceBrastianos PK, 2014, NAT GENET, V46, P161, DOI 10.1038/ng.2868
hcfmusp.relation.referenceCani CMG, 2011, CLINICS, V66, P1849, DOI 10.1590/S1807-59322011001100001
hcfmusp.relation.referenceChen JH, 2005, ENDOCRINOLOGY, V146, P3985, DOI 10.1210/en.2005-0185
hcfmusp.relation.referenceChen JH, 2009, STEM CELLS, V27, P1182, DOI 10.1002/stem.51
hcfmusp.relation.referenceChen LC, 2014, CANCER LETT, V349, P61, DOI 10.1016/j.canlet.2014.03.031
hcfmusp.relation.referenceClark AJ, 2012, J NEUROSURG-PEDIATR, V10, P293, DOI 10.3171/2012.7.PEDS11436
hcfmusp.relation.referenceEe PLR, 2004, MOL CANCER THER, V3, P1577
hcfmusp.relation.referenceFauquier T, 2008, P NATL ACAD SCI USA, V105, P2907, DOI 10.1073/pnas.0707886105
hcfmusp.relation.referenceFrank S, 1996, BIOCHEM BIOPH RES CO, V222, P794, DOI 10.1006/bbrc.1996.0823
hcfmusp.relation.referenceGagliano T, 2013, PITUITARY, V16, P91, DOI 10.1007/s11102-012-0380-1
hcfmusp.relation.referenceGarcia-Lavandeira M, 2009, PLOS ONE, V4, DOI 10.1371/journal.pone.0004815
hcfmusp.relation.referenceGarcia-Lavandeira M, 2012, J CLIN ENDOCR METAB, V97, pE80, DOI 10.1210/jc.2011-2187
hcfmusp.relation.referenceGaston-Massuet C, 2011, P NATL ACAD SCI USA, V108, P11482, DOI 10.1073/pnas.1101553108
hcfmusp.relation.referenceGleiberman AS, 2008, P NATL ACAD SCI USA, V105, P6332, DOI 10.1073/pnas.0801644105
hcfmusp.relation.referenceGomes DC, 2015, EUR J ENDOCRINOL, V172, P603, DOI 10.1530/EJE-14-0934
hcfmusp.relation.referenceGunthert U, 1993, Curr Top Microbiol Immunol, V184, P47
hcfmusp.relation.referenceGunthert U, 1996, CURR TOP MICROBIOL, V213, P271
hcfmusp.relation.referenceGuzzo MF, 2015, J NEUROENDOCRINOL, V27, P616, DOI 10.1111/jne.12277
hcfmusp.relation.referenceHaslam IS, 2011, DRUG METAB DISPOS, V39, P2321, DOI 10.1124/dmd.111.038323
hcfmusp.relation.referenceHolsken A, 2014, PITUITARY, V17, P546, DOI 10.1007/s11102-013-0543-8
hcfmusp.relation.referenceJayakody SA, 2012, J CLIN INVEST, V122, P3635, DOI 10.1172/JCI64311
hcfmusp.relation.referenceKaravitaki N, 2006, ENDOCR REV, V27, P371, DOI 10.1210/er.2006-0002
hcfmusp.relation.referenceKomminoth P, 1996, HISTOCHEM CELL BIOL, V106, P551
hcfmusp.relation.referenceLiu W, 2012, CANCER-AM CANCER SOC, V118, P1693, DOI 10.1002/cncr.26483
hcfmusp.relation.referenceMCCARTY KS, 1985, ARCH PATHOL LAB MED, V109, P716
hcfmusp.relation.referenceMertens F, 2015, ENDOCR-RELAT CANCER, V22, P481, DOI 10.1530/ERC-14-0546
hcfmusp.relation.referenceOikonomou E, 2005, J NEURO-ONCOL, V73, P205, DOI 10.1007/s11060-004-5232-z
hcfmusp.relation.referenceOuspenskaia T, 2016, CELL, V164, P156, DOI 10.1016/j.cell.2015.11.058
hcfmusp.relation.referencePan GJ, 2007, CELL RES, V17, P42, DOI 10.1038/sj.cr.7310125
hcfmusp.relation.referencePreda V, 2015, ENDOCR PATHOL, V26, P1, DOI 10.1007/s12022-014-9341-8
hcfmusp.relation.referenceRaetzman LT, 2004, DEV BIOL, V265, P329, DOI 10.1016/j.ydbio.2003.09.033
hcfmusp.relation.referenceRizzoti K, 2013, CELL STEM CELL, V13, P419, DOI 10.1016/j.stem.2013.07.006
hcfmusp.relation.referenceSalehi F, 2009, NEUROSURGERY, V65, P429, DOI 10.1227/01.NEU.0000349930.66434.82
hcfmusp.relation.referenceSato K, 2006, CLIN NEUROPATHOL, V25, P25
hcfmusp.relation.referenceScott CE, 2010, NAT NEUROSCI, V13, P1181, DOI 10.1038/nn.2646
hcfmusp.relation.referenceSekine S, 2002, AM J PATHOL, V161, P1997, DOI 10.1016/S0002-9440(10)64477-X
hcfmusp.relation.referenceSughrue ME, 2011, PITUITARY, V14, P276, DOI 10.1007/s11102-011-0308-1
hcfmusp.relation.referenceTunici P, 2009, METHODS MOL BIOL, V568, P195, DOI 10.1007/978-1-59745-280-9_12
hcfmusp.relation.referenceVankelecom H, 2010, EUR J NEUROSCI, V32, P2063, DOI 10.1111/j.1460-9568.2010.07523.x
hcfmusp.relation.referenceXing B, 2013, BIOMED ENVIRON SCI, V26, P592, DOI 10.3967/0895-3988.2013.07.011
hcfmusp.relation.referenceXu Q, 2009, BRIT J CANCER, V101, P303, DOI 10.1038/sj.bjc.6605142
hcfmusp.relation.referenceZhu XY, 2006, GENE DEV, V20, P2739, DOI 10.1101/gad.1444706
hcfmusp.relation.referenceZoller M, 2011, NAT REV CANCER, V11, P254, DOI 10.1038/nrc3023
hcfmusp.scopus.lastupdate2024-05-17
relation.isAuthorOfPublicationf03bd362-410f-43c7-96d9-94ce5fbccec6
relation.isAuthorOfPublicationa993a6b0-a0c7-4824-b19b-66fc83345249
relation.isAuthorOfPublication1e8cfb9d-6cb2-41db-9df7-635811357c4f
relation.isAuthorOfPublicationa481603e-cea4-445c-bdb8-12a6f5a5c200
relation.isAuthorOfPublication05172b40-4023-4cac-aecb-f9632abcbc59
relation.isAuthorOfPublication71cbe6cf-ec3c-4df8-bc56-ff122fd165f6
relation.isAuthorOfPublicationf9dd8bf5-173e-4843-93cd-66012ee0ef1b
relation.isAuthorOfPublication2d7ecbc5-e278-4b88-950f-39267392ea1c
relation.isAuthorOfPublication.latestForDiscoveryf03bd362-410f-43c7-96d9-94ce5fbccec6
Arquivos
Pacote Original
Agora exibindo 1 - 1 de 1
Nenhuma Miniatura disponível
Nome:
art_CHANG_Differential_Expression_of_Stem_Cell_Markers_in_Human_2017.PDF
Tamanho:
1.23 MB
Formato:
Adobe Portable Document Format
Descrição:
publishedVersion (English)
Baixar
Coleções
Artigos e Materiais de Revistas Científicas - FM/MPT
Artigos e Materiais de Revistas Científicas - FM/MCM
Artigos e Materiais de Revistas Científicas - HC/ICESP
Artigos e Materiais de Revistas Científicas - HC/ICHC
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/14
Carregar mais