Steatosis and steatohepatitis found in adults after death due to non-burn trauma

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorREIS-JUNIOR, Paulo
dc.contributor.authorTANIGAWA, Ryan
dc.contributor.authorMESQUITA, Gustavo Heluani Antunes de
dc.contributor.authorBASAN, Natalia
dc.contributor.authorALVES, Venancio
dc.contributor.authorD'ALBUQUERQUE, Luiz Augusto Carneiro
dc.contributor.authorANDRAUS, Wellington
dc.date.accessioned2020-03-24T14:52:21Z
dc.date.available2020-03-24T14:52:21Z
dc.date.issued2019
dc.description.abstractOBJECTIVE: With the increasing prevalence of steatosis, the number of steatotic liver grafts from deceased donors is also increasing. Thus, determining the prevalence and the population risk factors of steatosis may assist in risk stratification. The aim of this study was to evaluate the prevalence and predictors of steatosis and steatohepatitis among livers from adults who died due to non-burn trauma. METHODS: Specimens were collected from 224 adults undergoing autopsy at a regional autopsy referral center from September 2011 to April 2013. Histopathological examination was performed on six samples obtained from different lobes of each liver. The outcomes of interest were the presence of steatosis, steatohepatitis, NASH inflammation and NASH fibrosis. The main predictors were body mass index, abdominal circumference, liver weight and volume, presence of cholelithiasis, and siderosis. Our modeling strategy made use of a series of generalized linear models with a binomial family. RESULTS: Our sample had a mean age of 40 years; steatosis was diagnosed in 48.2% of cases, and steatohepatitis was diagnosed in 2.7%. The presence of a high proportion of fatty changes was more prevalent among males and older individuals, with the most affected age group being 41-60 years. When evaluating the crude odds ratio for steatosis, the factors significantly associated with an increased risk of steatosis were greater abdominal circumference, BMI, and liver weight and the presence of siderosis. CONCLUSION: Our study reinforces the role of older age, obesity and hepatomegaly as predictors of fatty liver disease. These variables should be considered in the assessment of fatty changes in the livers of potential liver donors.eng
dc.description.indexMEDLINEeng
dc.identifier.citationCLINICS, v.74, article ID e1070, 8p, 2019
dc.identifier.doi10.6061/clinics/2019/e1070
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/35522
dc.language.isoeng
dc.publisherHOSPITAL CLINICAS, UNIV SAO PAULOeng
dc.relation.ispartofClinics
dc.rightsopenAccesseng
dc.rights.holderCopyright HOSPITAL CLINICAS, UNIV SAO PAULOeng
dc.subjectSteatosiseng
dc.subjectSteatohepatitiseng
dc.subjectFatty Livereng
dc.subjectLiver Diseaseeng
dc.subjectAuthopsyeng
dc.subject.otherfatty liver-diseaseeng
dc.subject.otherhepatic steatosiseng
dc.subject.otherrisk-factorseng
dc.subject.othernonalcoholic steatohepatitiseng
dc.subject.otheroxidative stresseng
dc.subject.othernatural-historyeng
dc.subject.otherobese-patientseng
dc.subject.otherweight-losseng
dc.subject.otherprevalenceeng
dc.subject.otherironeng
dc.subject.wosMedicine, General & Internaleng
dc.titleSteatosis and steatohepatitis found in adults after death due to non-burn traumaeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalREIS-JUNIOR, Paulo:Univ Fed Tocantins, Fac Med, Palmas, TO, Brazil
hcfmusp.author.externalBASAN, Natalia:Univ Fed Tocantins, Fac Med, Palmas, TO, Brazil
hcfmusp.citation.scopus2
hcfmusp.contributor.author-fmusphcRYAN YUKIMATSU TANIGAWA
hcfmusp.contributor.author-fmusphcGUSTAVO HELUANI ANTUNES DE MESQUITA
hcfmusp.contributor.author-fmusphcVENANCIO AVANCINI FERREIRA ALVES
hcfmusp.contributor.author-fmusphcLUIZ AUGUSTO CARNEIRO D ALBUQUERQUE
hcfmusp.contributor.author-fmusphcWELLINGTON ANDRAUS
hcfmusp.description.articlenumbere1070
hcfmusp.description.volume74
hcfmusp.origemWOS
hcfmusp.origem.pubmed31618320
hcfmusp.origem.scieloSCIELO:S1807-59322019000100281
hcfmusp.origem.scopus2-s2.0-85073466708
hcfmusp.origem.wosWOS:000506312400001
hcfmusp.publisher.citySAO PAULOeng
hcfmusp.publisher.countryBRAZILeng
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