Role of radiation in rectal cancers
Nenhuma Miniatura disponível
Citações na Scopus
0
Tipo de produção
bookPart
Data de publicação
2015
Título da Revista
ISSN da Revista
Título do Volume
Editora
SPRINGER NEW YORK
Citação
Habr-Gama, A.; Jorge, J. M. N.; Bustamante-Lopez, L. A.. Role of radiation in rectal cancers. In: . RADIATION THERAPY FOR PELVIC MALIGNANCY AND ITS CONSEQUENCES: SPRINGER NEW YORK, 2015. p.53-64.
Resumo
The management of rectal cancer has dramatically improved during the last two decades and therapeutic decisions should now be individualized and based on a multidisciplinary approach, involving radiation oncologists, medical oncologists, diagnostic radiologists, surgeons, pathologists, and primary care physicians. The benefits of preoperative chemoradiotherapy include downsizing, downstaging, improved sphincter-preservation rates, and reduced local recurrence. In addition, complete pathological response is possible in a significant percentage of patients. The combination of neoadjuvant radiotherapy and total mesorectal excision may result in significant long-term adverse effects, including sexual and anorectal sphincter dysfunction. This should be taken into account during selection of patients for radiotherapy. In addition, ongoing trials are addressing quality of life issues with modern radiation techniques and newer chemotherapeutic agents. © Springer Science+Business Media, LLC 2015.
Palavras-chave
Chemoradiation, Downstaging, Low rectal cancer, Neoadjuvant therapy, Radiotherapy, Recurrence, Sphincter-saving, Survival
Referências
- Cohen, A.M., Adjuvant therapy in rectal cancer (1992) Hepatogastroenterology, 39, pp. 215-221
- Rider, W.D., Palmer, J.A., Mahoney, I.J., Robertson, C.T., Preoperative irradiation in operable cancer of the rectum: Report of the Toronto Trial (1977) Can J Surg, 20, pp. 335-338
- Rich, T., Gundenson, L.L., Lew, R., Galdibini, J.J., Cohen, A.M., Donaldson, G., Patterns of recurrence of rectal cancer after potentially curative surgery (1983) Cancer, 52, pp. 1317-1329
- Boulis-Wassif, S., Gerard, A., Loygue, J., Camelot, D., Buyse, M., Suez, N., Final results of a randomized trial on the treatment of rectal cancer with preoperative radiotherapy alone or in a combination with 5-fluorouracil, followed by radical surgery. Trial of the European Organization on Research and Treatment of Gastrointestinal Cancer Cooperative Group (1984) Cancer, 53, pp. 1811-1818
- Garcia-Aguilar, J., Transanal Endoscopic microsurgery following neoadjuvant chemoradiation therapy in rectal cancer: A word of caution about patient selection? (2013) Dis Colon Rectum, 56, pp. 1-3
- Heald, R.J., Husband, E.M., Ryall, R.D., The mesorectum in rectal cancer surgery-the clue to pelvic recurrence? (1982) Br J Surg, 69, pp. 613-616
- Williamson, P.R., Hellinger, M.D., Larach, S.W., Ferrara, A., Endorectal ultrasound of T3 and T4 rectal cancers after preoperative chemoradiation (1996) Dis Colon Rectum, 39, pp. 45-49
- Brown, G., Kirkham, A., Is high-resolution MRI of the anatomy important in total mesorectal excision of the rectum (2004) Gastrointestinal Imaging, 182, pp. 431-439
- Quirke, P., Dudley, P., Dixon, M.F., Williams, N.S., Local recurrence of rectal adenocarcinoma due to inadequate surgical resection. Histopathological study of lateral tumour spread and surgical excision (1986) The Lancet, 2, pp. 996-999
- Prolongation of the disease-free interval in surgically treated rectal carcinoma (1985) N Engl J Med, 312, pp. 1465-1472
- Fisher, B., Wolmark, N., Rockette, H., Redmond, C., Deutsch, M., Wickerham, D.L., Fisher, E.R., Lerner, H., Postoperative adjuvant chemotherapy or radiation for rectal cancer: Results from NSABP protocol R-01 (1988) J Natl Cancer Inst, 80, pp. 21-29
- Krook, J.E., Moertel, C.G., Gunderson, L.L., Effective surgical adjuvant therapy for high-risk rectal carcinoma (1991) N Engl J Med, 324, pp. 709-715
- Adjuvant therapy for high risk rectal carcinoma (1990) JAMA, 264, pp. 1444-1450
- Monson, J.R.T., Weiser, M.R., Buie, W.D., Chang, G.J., Rafferty, J.F., Practice parameters for the management of rectal cancer (revised) (2013) Dis Colon Rectum, 56, pp. 535-550
- Popek, S., Tsikitis, V.L., Neoadjuvant vs adjuvant pelvic radiation for locally advanced rectal cancer: Which is superior? (2011) World J Gastroenterol, 17, pp. 848-854
- Valentini, V., Beets Tan, R., Borras, J.M., Krivokapic, Z., Leer, J.W., Pahlman, L., Rodel, C., Verfaillie, C., Evidence and research in rectal cancer (2008) Radiother Oncol, 87, pp. 449-474
- Improved survival with preoperative radiotherapy radiotherapy in resectable rectal cancer (1997) N Engl J Med, 336, pp. 980-987
- Folkesson, J., Birgisson, H., Pahlman, L., Cedermark, B., Glimelius, B., Gunnarsson, U., The Swedish Rectal Cancer Trial: Long lasting benefits from radiotherapy on survival and local recurrence rate (2005) J Clin Oncol, 23, pp. 5644-5650
- Birgisson, H., Pahlman, L., Gunnarsson, U., Glimelius, B., Adverse effects of preoperative radiation for rectal cancer: Long-term follow-up of the Swedish Rectal Cancer Trial (2005) J Clin Oncol, 23, pp. 8697-8705
- Kapiteijin, E., Marijnem, C.A., Nagtegaal, I.D., Putter, H., Steup, W.H., Wiggers, T., Rutten, H.J., Van De Velde, C.J., Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision fore resectable rectal cancer (2001) N Engl J Med, 345, pp. 638-646
- Van Gijn, W., Marijnem, C.A., Nagtegaal, I.D., Kranenbarg, E.M., Putter, H., Wiggers, T., Rutten, H.J., Van De, V.C.J., Dutch Colorectal Cancer Group. Preoperative radiotherapy combined with total mesorectal excision fore resectable rectal cancer: 12 year follow-up of the multicentre, randomized controlled TME trial (2011) Lancet Oncol, 12, pp. 575-582
- Sauer, R., Becker, H., Hohenberger, W., Rodel, C., Wittekind, C., Fietkau, R., Martus, P., Raab, R., German Rectal Cancer Study Group. Preoperative versus postoperative chemoradiotherapy for rectal cancer (2004) N Engl J Med, 351, pp. 1731-1740
- Rahbari, N.N., Elbers, H., Askoxylakis, V., Motschall, E., Bork, U., Buchler, M.W., Weitz, J., Koch, M., Neoadjuvant radiotherapy for rectal cancer: Meta-analysis of randomized controlled trials (2013) Ann Surg Oncol, 20, pp. 4169-4182
- Holm, T., Singnomklao, T., Rutqvist, L.E., Cedermark, B., Adjuvant preoperative radiotherapy in patients with rectal carcinoma. Adverse effects during long term follow-up of two randomized trials (1996) Cancer, 78, pp. 967-976
- Habr-Gama, A., de Souza, P.M.S.B., Ribeiro, U., Jr., Nadalin, W., Gansl, R., Sousa, A.H.S., Jr., Campos, F.G., Gama-Rodrigues, J., Low rectal cancer. Impact in radiation and chemotherapy on surgical treatment (1998) Dis Colon Rectum, 41, pp. 1087-1096
- Habr-Gama, A., Perez, R.O., Nadalin, W., Sabbaga, J., Ribeiro, U.J.R., Silva e Sousa, A.H., Jr., Campos, F.G., Gama-Rodrigues, J., Operative versus nonoperative treatment for stage 0 distal rectal cancer following chemoradiation therapy: Long-term results. Ann 38 (2004) Surg, 240, pp. 711-717
- Bujko, K., Nowacki, M.P., Nasierowska-Guttmejer, A., Michalschi, W., Bebenek, M., Kryj, M., Sphincter preservation following preoperative radiotherapy for rectal cancer: Report of a randomized trial comparing preoperative short-term radiotherapy vs conventionally fractionated chemoradiotherapy (2004) Radiother Oncol, 72, pp. 15-24
- Bujko, K., Nowacki, M.P., Nasierowska-Guttmejer, A., Michalski, W., Bebenek, M., Kryj, M., Long term results of a randomized trial comparing preoperative shortcourse radiotherapy with preoperative conventionally fractioned chemoradiation for rectal cancer (2006) Br J Surg, 93, pp. 1215-1223
- Perez, R.O., Habr-Gama, A., São, J.G.P., Proscurshim, I., Scanavini Neto, A., Gama-Rodrigues, J., Transanal endoscopic microsurgery for residual rectal cancer after neoadjuvant chemoradiation therapy is associated with significant immediate pain and hospital readmission rates (2011) Dis Colon Rectum, 54, pp. 545-551
- Habr-Gama, A., Sabbaga, J., Gama-Rodrigues, J., Sao Juliao, G.P., Proscurshim, I., Aguilar, P.B., Nadalin, W., Perez, R.O., Watch and Wait approach following extended neoadjuvant chemoradiation for distal rectal cancer: Are we getting closer to anal cancer management? (2013) Dis Colon Rectum, 56, pp. 1109-1117
- Habr-Gama, A., Perez, R.O., Sabbaga, J., Nadalin, W., São Juliao, G.P., Gama-Rodrigues, J., Increasing the rates of complete response to neoadjuvant chemoradiotherapy for distal rectal cancer: Results of a prospective study using additional chemotherapy during the resting period (2009) Dis Colon Rectum, 52, pp. 1927-1934
- Gérard, J.P., Azria, D., Gourgou-Bourgade, S., Comparison of two neoadjuvant chemoradiotherapy regimens for locally advanced rectal caˆncer: Results of teh phase III Trial ACCORD 12/0405-Prodige 2 (2010) J Clin Oncol, 28, pp. 1638-1644
- Habr-Gama, A., Perez, R.O., Proscurshin, I., Gama-Rodrigues, J., Complete clinical response after neoadjuvant chemoradiation for distal rectal cancer (2010) Surg Oncol Clin N Am, 19, pp. 829-845
- Varpe, P., Huhtinen, H., Rantala, A., Salminen, P., Rautava, P., Hurme, S., Gronroos, J., Quality of life after surgery for rectal cancer with special reference to pelvic floor dysfunction (2011) Colorectal Dis, 1, pp. 399-405
- Knowles, G., Haigh, R., McLean, C., Phillips, H.A., Dunlop, M., Din, F.V.N., Long term effect of surgery and radiotherapy for colorectal cancer on defecatory function and quality of life (2013) Eur J Oncol Nursing, 17, pp. 570-577
- Vordermark, D., Schwab, M., Ness-Dourdoumas, R., Sailer, M., Flentje, M., Koebl, O., Association of anorectal dose-volume histograms and impaired fecal continence after 3D conformal radiotherapy for carcinoma of the prostate (2003) Radiother Oncol, 69, pp. 209-214
- Fokdal, L., Honoré, H., Hoyer, M., Von Der, M., Dosevolume histograms associated long-term colorectal funcionts in patients receiving pelvic radiotherapy (2013) Radiother Oncol, 74, pp. 203-210
- Lacombe, J., Azria, D., Mange, A., Solassol, J., Proteomic approaches to identify biomarkers predictive of radiotherapy outcomes (2013) Exp Rev Proteomics, 10, pp. 33-42
- Tan, J., Herlot, A.G., Mackay, J., Van Dyk, S., Bressel, M.A.B., Fox, C.D., Hui, A.C., Ngan, S.Y., Prospective single-arm study of intraoperative radiotherapy for locally advanced or recurrent rectal cancer (2013) J Med Imag Radiation Oncol, 57, pp. 617-625
- Hoffe, S.E., Shridhar, R., Biagiotti, M.C., Radiation therapy for rectal cancer: Current status and future directions (2010) Cancer Control, 17, pp. 25-34
- Turley, R.S., Czito, B.G., Haney, J.C., Tyler, D.S., Mantyh, C.R., Migaly, J., Intraoperative pelvic brachytherapy for treatment of locally advanced or recurrent colorectal cancer (2013) Tech Coloproctol, 17, pp. 95-100
- Morimoto, M., Isohashi, F., Yoshioka, Y., Suzuki, O., Seo, Y., Ogata, T., Akini, Y., Ogawa, K., Salvage high-dose-rate interstitial brachytherapy for locally recurrent rectal cancer: Long term follow-up results (2013) Int J Clin Oncol, , (Published on line: 01 June)