LIPID TRANSFER TO HIGH DENSITY LIPOPROTEINS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE

Página do item simplificado
dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorSPRANDEL, Marilia C. O.
dc.contributor.authorHUEB, Whady
dc.contributor.authorCASELLA-FILHO, Antonio
dc.contributor.authorSEGRE, Alexandre
dc.contributor.authorREZENDE, Paulo Cury
dc.contributor.authorCARVALHO, Ana L. O.
dc.contributor.authorFAVARATO, Desiderio
dc.contributor.authorMARANHAO, Raul C.
dc.contributor.authorRAMIRES, Jose
dc.contributor.authorKALIL-FILHO, Roberto
dc.date.accessioned2013-10-11T21:17:45Z
dc.date.available2013-10-11T21:17:45Z
dc.date.issued2012
dc.description.abstractBackground In type 2 diabetes mellitus (DM2), HDL-cholesterol is diminished and it is important to understand the functional and metabolic changes existing in HDL in DM2 patients that may predispose to coronary artery disease (CAD). Lipid transfers between HDL and the other lipoproteins, mediated by cholesteryl ester transfer protein (CETP) and phospholipid transfer protein (PLTP), are crucial steps in HDL formation and role in reverse cholesterol transfer. Objective Investigate whether development of CAD in DM2 patients are associated with alterations in lipid transfers to HDL and in content of free cholesterol in the plasma. Methods 78 patients with DM2 and CAD (DM2-CAD) and 78 with DM2 without CAD, as diagnosed by cineangiography, were studied. They were of both genders, aged 40-80 yrs. Plasma was incubated for 1h at 37oC with a donor nanoemulsion labeled with 3H -cholesteryl-esters and14C -phospholipids or with 14C-free-cholesterol and 3H -triglycerides. Radioactive lipids transferred from the donor nanoemulsion to HDL were measured in the supernatant after chemical precipitation of non-HDL fractions and the nanoemulsion. Results are % of the total radioactivity of each lipid in HDL. Results In DM2-CAD, LDL-cholesterol and triglycerides were higher than in DM2; HDL-cholesterol was lower. Compared to DM2, DM2-CAD showed diminished transfer to HDL of free-cholesterol (DM2-CAD=4.23±0.24; DM2= 5.66±0.14, p<0.0001) and of triglycerides (1.65±0.13 vs 3.08±0.11, p<0.0001), whereas cholesteryl-ester transfer was increased (3.67±0.16 vs 2.25±0.13, p<0.0001); phospholipid transfer was equal (15.37±0.60 vs15.18±0.20, p=0.76). CETP concentration was equal, while plasma free-cholesterol was higher in DM2-CAD (DM2-CAD=36.9±0.9; DM2=33.1±0.7, p=0.003).HDL particle diameter was equal in both groups. Conclusion The reduction of free-cholesterol transfer to HDL may hinder cholesterol esterification and reverse cholesterol transport. Alterations in triglyceride and cholesteryl-ester transfer may affect lipoprotein stability. Those disturbances in HDL metabolism may facilitate CAD development in DM2. ACC Oral Contributions McCormick Place South, S100c Sunday, March 25, 2012, 9:04 a.m.-9:17 a.m. Session Title: Prevention: Focus on Lipids Abstract Category: 9. Prevention: Clinical Presentation Number: 911-8
dc.description.conferencedateMAR 24-27, 2012
dc.description.conferencelocalChicago - IL, EUA
dc.description.conferencename61st Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC)
dc.description.indexMEDLINE
dc.identifier.citationJOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, v.59, n.13, suppl.S, p.E1623-E1623, 2012
dc.identifier.issn0735-1097
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/2811
dc.language.isoeng
dc.publisherELSEVIER SCIENCE INC
dc.relation.ispartofJournal of the American College of Cardiology
dc.rightsrestrictedAccess
dc.rights.holderCopyright ELSEVIER SCIENCE INC
dc.subject.wosCardiac & Cardiovascular Systems
dc.titleLIPID TRANSFER TO HIGH DENSITY LIPOPROTEINS IN TYPE 2 DIABETIC PATIENTS WITH AND WITHOUT CORONARY ARTERY DISEASE
dc.typeconferenceObject
dc.type.categorymeeting abstract
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.contributor.author-fmusphcMARILIA DA COSTA OLIVEIRA SPRANDEL
hcfmusp.contributor.author-fmusphcWHADY ARMINDO HUEB
hcfmusp.contributor.author-fmusphcANTONIO CASELLA FILHO
hcfmusp.contributor.author-fmusphcCARLOS ALEXANDRE WAINROBER SEGRE
hcfmusp.contributor.author-fmusphcPAULO CURY REZENDE
hcfmusp.contributor.author-fmusphcANA LUIZA DE OLIVEIRA CARVALHO
hcfmusp.contributor.author-fmusphcDESIDERIO FAVARATO
hcfmusp.contributor.author-fmusphcRAUL CAVALCANTE MARANHAO
hcfmusp.contributor.author-fmusphcJOSE ANTONIO FRANCHINI RAMIRES
hcfmusp.contributor.author-fmusphcROBERTO KALIL FILHO
hcfmusp.description.beginpageE1623
hcfmusp.description.endpageE1623
hcfmusp.description.issue13
hcfmusp.description.issuesuppl S
hcfmusp.description.volume59
hcfmusp.origemWOS
hcfmusp.origem.wosWOS:000302326701734
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
relation.isAuthorOfPublicationd79fd9a9-25f2-417d-baee-752edc32729c
relation.isAuthorOfPublication60b53bfd-695d-4a77-a444-de58fb0bada0
relation.isAuthorOfPublication2bad9edd-56cd-4942-9265-bd0bee7ab1bd
relation.isAuthorOfPublication3f3f95a5-fe18-40fd-af99-0f6397fc5174
relation.isAuthorOfPublication88850f7d-56cd-4ba5-b2d4-b824b64b15c4
relation.isAuthorOfPublication4beacbc1-b94a-41b0-a0f5-e47677c8e632
relation.isAuthorOfPublication16447101-33a6-4639-8773-379b68d0c1e0
relation.isAuthorOfPublication4437a063-fe85-4853-b700-f5dd69521c43
relation.isAuthorOfPublicationf5d62c04-a7ad-4984-95b7-4b603eceb3da
relation.isAuthorOfPublicationc934e4bf-7bb3-4e4d-aaac-07d8be41a3ac
relation.isAuthorOfPublication.latestForDiscoveryd79fd9a9-25f2-417d-baee-752edc32729c
Arquivos
Coleções
Comunicações em Eventos - FM/MCP
Comunicações em Eventos - HC/InCor
Comunicações em Eventos - LIM/11
Comunicações em Eventos - LIM/31