Evaluation of Non-Invasive Methods for (R)-[<SUP>11</SUP>C]PK11195 PET Image Quantification in Multiple Sclerosis

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorMANTOVANI, Dimitri B. A.
dc.contributor.authorPITOMBEIRA, Milena S.
dc.contributor.authorSCHUCK, Phelipi N.
dc.contributor.authorARAUJO, Adriel S. de
dc.contributor.authorBUCHPIGUEL, Carlos Alberto
dc.contributor.authorFARIA, Daniele de Paula
dc.contributor.authorSILVA, Ana Maria M. da
dc.date.accessioned2024-04-05T19:30:40Z
dc.date.available2024-04-05T19:30:40Z
dc.date.issued2024
dc.description.abstractThis study aims to evaluate non-invasive PET quantification methods for (R)-[C-11]PK11195 uptake measurement in multiple sclerosis (MS) patients and healthy controls (HC) in comparison with arterial input function (AIF) using dynamic (R)-[C-11]PK11195 PET and magnetic resonance images. The total volume of distribution (VT) and distribution volume ratio (DVR) were measured in the gray matter, white matter, caudate nucleus, putamen, pallidum, thalamus, cerebellum, and brainstem using AIF, the image-derived input function (IDIF) from the carotid arteries, and pseudo-reference regions from supervised clustering analysis (SVCA). Uptake differences between MS and HC groups were tested using statistical tests adjusted for age and sex, and correlations between the results from the different quantification methods were also analyzed. Significant DVR differences were observed in the gray matter, white matter, putamen, pallidum, thalamus, and brainstem of MS patients when compared to the HC group. Also, strong correlations were found in DVR values between non-invasive methods and AIF (0.928 for IDIF and 0.975 for SVCA, p < 0.0001). On the other hand, (R)-[C-11]PK11195 uptake could not be differentiated between MS patients and HC using VT values, and a weak correlation (0.356, p < 0.0001) was found between VTAIF and VTIDIF. Our study shows that the best alternative for AIF is using SVCA for reference region modeling, in addition to a cautious and appropriate methodology.eng
dc.description.indexPubMed
dc.description.indexScopus
dc.description.indexDimensions
dc.description.indexWoS
dc.description.sponsorshipGE Healthcare
dc.identifier.citationJOURNAL OF IMAGING, v.10, n.2, article ID 39, 14p, 2024
dc.identifier.doi10.3390/jimaging10020039
dc.identifier.eissn2313-433X
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/58846
dc.language.isoeng
dc.publisherMDPIeng
dc.relation.ispartofJournal of Imaging
dc.rightsopenAccesseng
dc.rights.holderCopyright MDPIeng
dc.subjectTSPOeng
dc.subjectneuroinflammationeng
dc.subjectkinetic modellingeng
dc.subjectquantificationeng
dc.subjectimage-derived input functioneng
dc.subject.otherin-vivoeng
dc.subject.othergraphical analysiseng
dc.subject.otherinput functioneng
dc.subject.otherbraineng
dc.subject.otheractivationeng
dc.subject.othermicrogliaeng
dc.subject.otherdiseaseeng
dc.subject.otherbindingeng
dc.subject.wosImaging Science & Photographic Technologyeng
dc.titleEvaluation of Non-Invasive Methods for (R)-[<SUP>11</SUP>C]PK11195 PET Image Quantification in Multiple Sclerosiseng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.affiliation.countryEstados Unidos
hcfmusp.affiliation.countryisous
hcfmusp.author.externalSCHUCK, Phelipi N.:Weill Cornell Med Coll, New York, NY 10065 USA
hcfmusp.author.externalARAUJO, Adriel S. de:Pontificia Univ Catolica Rio Grande Sul PUCRS, Grad Program Comp Sci, BR-90619900 Porto Alegre, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcDIMITRI BRIGIDE DE ALMEIDA MANTOVANI
hcfmusp.contributor.author-fmusphcMILENA SALES PITOMBEIRA
hcfmusp.contributor.author-fmusphcCARLOS ALBERTO BUCHPIGUEL
hcfmusp.contributor.author-fmusphcDANIELE DE PAULA FARIA
hcfmusp.contributor.author-fmusphcANA MARIA MARQUES DA SILVA
hcfmusp.description.articlenumber39
hcfmusp.description.issue2
hcfmusp.description.volume10
hcfmusp.origemWOS
hcfmusp.origem.dimensionspub.1168473165
hcfmusp.origem.pubmed38392087
hcfmusp.origem.scopus2-s2.0-85185707466
hcfmusp.origem.wosWOS:001175084200001
hcfmusp.publisher.cityBASELeng
hcfmusp.publisher.countrySWITZERLANDeng
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