Vitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorKRONENBERGER, Thales
dc.contributor.authorLINDNER, Jasmin
dc.contributor.authorMEISSNER, Kamila A.
dc.contributor.authorZIMBRES, Flavia M.
dc.contributor.authorCORONADO, Monika A.
dc.contributor.authorSAUER, Frank M.
dc.contributor.authorSCHETTERT, Isolmar
dc.contributor.authorWRENGER, Carsten
dc.date.accessioned2014-04-28T22:13:28Z
dc.date.available2014-04-28T22:13:28Z
dc.date.issued2014
dc.description.abstractMalaria is a deadly infectious disease which affects millions of people each year in tropical regions. There is no effective vaccine available and the treatment is based on drugs which are currently facing an emergence of drug resistance and in this sense the search for new drug targets is indispensable. It is well established that vitamin biosynthetic pathways, such as the vitamin B6 de novo synthesis present in Plasmodium, are excellent drug targets. The active form of vitamin B6, pyridoxal 5-phosphate, is, besides its antioxidative properties, a cofactor for a variety of essential enzymes present in the malaria parasite which includes the ornithine decarboxylase (ODC, synthesis of polyamines), the aspartate aminotransferase (AspAT, involved in the protein biosynthesis), and the serine hydroxymethyltransferase (SHMT, a key enzyme within the folate metabolism).
dc.description.indexMEDLINE
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2009/54325-2, 2010/20647-0, 2011/13706-3, 2011/19703-6, 2012/12807-3, 2012/12790-3, 2013/10288-1]
dc.description.sponsorshipCAPES/DAAD [348/2013]
dc.identifier.citationBIOMED RESEARCH INTERNATIONAL, article ID 108516, 11p, 2014
dc.identifier.doi10.1155/2014/108516
dc.identifier.eissn2314-6141
dc.identifier.issn2314-6133
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/5517
dc.language.isoeng
dc.publisherHINDAWI PUBLISHING CORPORATION
dc.relation.ispartofBiomed Research International
dc.rightsopenAccess
dc.rights.holderCopyright HINDAWI PUBLISHING CORPORATION
dc.subject.others-adenosylmethionine decarboxylase
dc.subject.otherbifunctional ornithine-decarboxylase
dc.subject.otherphosphate-dependent enzymes
dc.subject.otherescherichia-coli k-12
dc.subject.otherserine hydroxymethyltransferase
dc.subject.otheraspartate-aminotransferase
dc.subject.otherde-novo
dc.subject.otherdihydrofolate-reductase
dc.subject.otherpyridoxal 5'-phosphate
dc.subject.otherpolyamine metabolism
dc.subject.wosBiotechnology & Applied Microbiology
dc.subject.wosMedicine, Research & Experimental
dc.titleVitamin B6-Dependent Enzymes in the Human Malaria Parasite Plasmodium falciparum: A Druggable Target?
dc.typearticle
dc.type.categoryreview
dc.type.versionpublishedVersion
dspace.entity.typePublication
hcfmusp.author.externalKRONENBERGER, Thales:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalLINDNER, Jasmin:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalMEISSNER, Kamila A.:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalZIMBRES, Flavia M.:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalCORONADO, Monika A.:Sao Paulo State Univ, Dept Phys, Multi User Ctr Biomol Innovat, UNESP IBILCE, BR-15054000 Sao Jose Do Rio Preto, SP, Brazil
hcfmusp.author.externalSAUER, Frank M.:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.author.externalWRENGER, Carsten:Univ Sao Paulo, Inst Biomed Sci, Dept Parasitol, Unit Drug Discovery, BR-05508000 Sao Paulo, Brazil
hcfmusp.citation.scopus18
hcfmusp.contributor.author-fmusphcISOLMAR TADEU SCHETTERT
hcfmusp.description.articlenumber108516
hcfmusp.description.volume2014
hcfmusp.origemWOS
hcfmusp.origem.pubmed24524072
hcfmusp.origem.scopus2-s2.0-84893177418
hcfmusp.origem.wosWOS:000330391500001
hcfmusp.publisher.cityNEW YORK
hcfmusp.publisher.countryUSA
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