Evaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapy

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dc.contributorSistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP
dc.contributor.authorNAKUTIS, Fernanda Serafim
dc.contributor.authorNISHITOKUKADO, Ieda
dc.contributor.authorSANTOS, Fabiana Maria dos
dc.contributor.authorORTIZ-AGOSTINHO, Carmen Lucia
dc.contributor.authorALENCAR, Daniel Teixeira de
dc.contributor.authorACHTSCHIN, Cassiana Ganem
dc.contributor.authorNUNES, Valeria Sutti
dc.contributor.authorLEITE, Andre Zonetti Arruda
dc.contributor.authorSIPAHI, Aytan Miranda
dc.date.accessioned2023-12-15T19:00:31Z
dc.date.available2023-12-15T19:00:31Z
dc.date.issued2023
dc.description.abstractIntroduction: Treatments of Inflammatory Bowel Disease (IBD) are able to control symptoms in most cases, how-ever, a fraction of patients do not improve or have a loss of response to treatments, making it important to explore new therapeutic strategies. Hyperbaric oxygen therapy (HBO) may represent one of them. The aim of this study was to evaluate the effects of HBO therapy in an experimental model of IBD. Methods: Sixty male BALBc mice were divided into six groups. Group 1 was colitis-induced with trinitrobenzene sulfonic acid (TNBS) + ethanol, group 2 received TNBS + ethanol plus HBO, group 3 received only ethanol, group 4 received ethanol plus HBO, group 5 received saline solution, and group 6 received saline solution plus HBO. HBO was performed for four days, subsequently, the mice were evaluated daily. At the end of the study, samples from the intestine were collected for histological analysis as well as for measurement of antioxidant enzymes and cytokine levels. Results: HBO significantly improved the clinical and histological status of the animals. Treatment with HBO increased the activity of the antioxidant enzymes superoxide dismutase (SOD) and glutathione peroxidase (GPx) in all of the groups; moreover, the difference was only significant between the TNBS and TNBS + HBO groups and treatments promoted a reduction in the proinflammatory cytokines IFN-gamma, IL-12, IL-17 and TNF-alpha and increased the anti-inflammatory cytokines IL-4 and IL-10, with no changes in IL-13. Conclusion: HBO effectively treats TNBS-induced colitis by increasing the activity of antioxidant enzymes and modulating cytokine profiles.eng
dc.description.indexMEDLINE
dc.description.indexPubMed
dc.description.indexWoS
dc.description.indexScopus
dc.identifier.citationCLINICS, v.78, article ID 100305, 9p, 2023
dc.identifier.doi10.1016/j.clinsp.2023.100305
dc.identifier.eissn1980-5322
dc.identifier.issn1807-5932
dc.identifier.urihttps://observatorio.fm.usp.br/handle/OPI/57650
dc.language.isoeng
dc.publisherELSEVIER ESPANAeng
dc.relation.ispartofClinics
dc.rightsopenAccesseng
dc.rights.holderCopyright ELSEVIER ESPANAeng
dc.subjectInflammatory bowel diseaseeng
dc.subjectExperimental modeleng
dc.subjectHyperbaric oxygen therapyeng
dc.subject.otherinflammatory-bowel-diseaseeng
dc.subject.otherulcerative-colitiseng
dc.subject.otherdouble-blindeng
dc.subject.otheranti-tnfeng
dc.subject.otheralphaeng
dc.subject.otherpathogenesiseng
dc.subject.othermechanismseng
dc.subject.otherexpressioneng
dc.subject.otherchallengeseng
dc.subject.otherratseng
dc.subject.wosMedicine, General & Internaleng
dc.titleEvaluation of oxidative stress in an experimental model of Crohn's disease treated with hyperbaric oxygen therapyeng
dc.typearticleeng
dc.type.categoryoriginal articleeng
dc.type.versionpublishedVersioneng
dspace.entity.typePublication
hcfmusp.author.externalNAKUTIS, Fernanda Serafim:Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Div Clin Gastroenterol & Hepatol, Lab Expt Clin Gastroenterol LIM 07, Sao Paulo, SP, Brazil
hcfmusp.author.externalACHTSCHIN, Cassiana Ganem:Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Div Clin Gastroenterol & Hepatol, Lab Expt Clin Gastroenterol LIM 07, Sao Paulo, SP, Brazil
hcfmusp.author.externalLEITE, Andre Zonetti Arruda:Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Div Clin Gastroenterol & Hepatol, Lab Expt Clin Gastroenterol LIM 07, Sao Paulo, SP, Brazil; Hosp Clin Fac Med Univ Sao Paulo HCFMUSP, Div Clin Gastroenterol & Hepatol, Sao Paulo, SP, Brazil
hcfmusp.citation.scopus0
hcfmusp.contributor.author-fmusphcIEDA NISHITOKUKADO
hcfmusp.contributor.author-fmusphcFABIANA MARIA DOS SANTOS
hcfmusp.contributor.author-fmusphcCARMEN LUCIA ORTIZ AGOSTINHO
hcfmusp.contributor.author-fmusphcDANIEL TEIXEIRA DE ALENCAR
hcfmusp.contributor.author-fmusphcVALERIA SUTTI NUNES
hcfmusp.contributor.author-fmusphcAYTAN MIRANDA SIPAHI
hcfmusp.description.articlenumber100305
hcfmusp.description.volume78
hcfmusp.origemWOS
hcfmusp.origem.pubmed37976650
hcfmusp.origem.scopus2-s2.0-85178536507
hcfmusp.origem.wosWOS:001113627400001
hcfmusp.publisher.cityMADRIDeng
hcfmusp.publisher.countrySPAINeng
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