Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/10041
Title: | Acellular matrix in urethral reconstruction |
Authors: | RIBEIRO-FILHO, Leopoldo Alves; SIEVERT, Karl-Dietrich |
Citation: | ADVANCED DRUG DELIVERY REVIEWS, v.82-83, p.38-46, 2015 |
Abstract: | The treatment of severe urethral stenosis has always been a challenge even for skilled urologists. Classic urethroplasty, skin flaps and buccal mucosa grafting may not be used for long and complex strictures. In the quest for an ideal urethral substitute, acellular scaffolds have demonstrated the ability to induce tissue regeneration layer by layer. After several experimental studies, the use of acellular matrices for urethral reconstruction has become a clinical reality over the last decade. In this review we analyze advantages and limitations of both biological and polymeric scaffolds that have been reported in experimental and human studies. Important aspects such as graft extension, surgical technique and cell-seeding versus cell-free grafts will be discussed. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/55 |
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art_RIBEIRO-FILHO_Acellular_matrix_in_urethral_reconstruction_2015.PDF Restricted Access | publishedVersion (English) | 886.15 kB | Adobe PDF | View/Open Request a copy |
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