Clinical features of tic-related obsessive-compulsive disorder: results from a large multicenter study

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art_ALVARENGA_Clinical_features_of_tic_related_obsessive_compulsive_disorder_2012.PDF (256 KB)
Citações na Scopus
58
Tipo de produção
article
Data de publicação
2012
DOI
Scopus
Web of Science
PubMed
Título da Revista
ISSN da Revista
Título do Volume
Editora
CAMBRIDGE UNIV PRESS
Autores
ROSARIO, Maria Conceicao do
FOSSALUZA, Victor
TORRES, Albina Rodrigues
Citação
CNS SPECTRUMS, v.17, n.2, p.87-93, 2012
Projetos de Pesquisa
Unidades Organizacionais
Fascículo
Resumo
Objective. To evaluate the clinical features of obsessive-compulsive disorder (OCD) patients with comorbid tic disorders (TD) in a large, multicenter, clinical sample. Method. A cross-sectional study was conducted that included 813 consecutive OCD outpatients from the Brazilian OCD Research Consortium and used several instruments of assessment, including the Yale-Brown Obsessive-Compulsive Scale, the Dimensional Yale-Brown Obsessive-Compulsive Scale, the Yale Global Tic Severity Scale (YGTSS), the USP Sensory Phenomena Scale, and the Structured Clinical Interview for DSM-IV Axis I Disorders. Results. The sample mean current age was 34.9 years old (SE 0.54), and the mean age at obsessive-compulsive symptoms (OCS) onset was 12.8 years old (SE 0.27). Sensory phenomena were reported by 585 individuals (72% of the sample). The general lifetime prevalence of TD was 29.0% (n=236), with 8.9% (n=72) presenting Tourette syndrome, 17.3% (n=5141) chronic motor tic disorder, and 2.8% (n=523) chronic vocal tic disorder. The mean tic severity score, according to the YGTSS, was 27.2 (SE 1.4) in the OCD1TD group. Compared to OCD patients without comorbid TD, those with TD (OCD1TD group, n=236) were more likely to be males (49.2% vs. 38.5%, p<005) and to present sensory phenomena and comorbidity with anxiety disorders in general: separation anxiety disorder, social phobia, specific phobia, generalized anxiety disorder, post-traumatic stress disorder, attention-deficit hyperactivity disorder, impulse control disorders in general, and skin picking. Also, the ""aggressive,"" ""sexual/religious,"" and ""hoarding"" symptom dimensions were more severe in the OCD+TD group. Conclusion. Tic-related OCD may constitute a particular subgroup of the disorder with specific phenotypical characteristics, but its neurobiological underpinnings remain to be fully disentangled.
Palavras-chave
Comorbidity, obsessive-compulsive disorder, tic disorder, Tourette syndrome
URI
https://observatorio.fm.usp.br/handle/OPI/1073
Referências
  1. BECK AT, 1988, J CONSULT CLIN PSYCH, V56, P893, DOI 10.1037/0022-006X.56.6.893
  2. BECK AT, 1961, ARCH GEN PSYCHIAT, V4, P561
  3. Bloch Michael H, 2008, Curr Psychiatry Rep, V10, P323, DOI 10.1007/s11920-008-0052-z
  4. Bloch MH, 2008, AM J PSYCHIAT, V165, P1532, DOI 10.1176/appi.ajp.2008.08020320
  5. Cath DC, 2001, J NERV MENT DIS, V189, P219, DOI 10.1097/00005053-200104000-00003
  6. Coffey BJ, 1998, J NERV MENT DIS, V186, P201, DOI 10.1097/00005053-199804000-00001
  7. de Mathis MA, 2008, EUR PSYCHIAT, V23, P187, DOI 10.1016/j.eurpsy.2008.01.002
  8. de Mathis MA, 2006, CNS SPECTRUMS, V11, P762
  9. de Mathis MA, 2009, CNS SPECTRUMS, V14, P362
  10. de Silva P, 1999, BEHAV RES THER, V37, P941, DOI 10.1016/S0005-7967(98)00185-5
  11. Diniz JB, 2004, J CLIN PSYCHIAT, V65, P22
  12. Diniz JB, 2006, J PSYCHIATR RES, V40, P487, DOI 10.1016/j.jpsychires.2006.09.002
  13. Ferrao YA, 2009, PSYCHIAT RES, V170, P32, DOI 10.1016/j.psychres.2008.06.008
  14. First M.B., 1995, STRUCTURED CLIN INTE
  15. Fontenelle LF, 2006, PROG NEURO-PSYCHOPH, V30, P327, DOI 10.1016/j.pnpbp.2005.11.001
  16. Fontenelle LF, 2012, J ANXIETY DISORD, V26, P377, DOI 10.1016/j.janxdis.2011.12.001
  17. Geller DA, 2006, PSYCHIAT CLIN N AM, V29, P353, DOI 10.1016/j.psc.2006.02.012
  18. GOODMAN WK, 1989, ARCH GEN PSYCHIAT, V46, P1006
  19. Grabe HJ, 2008, PSYCHOPATHOLOGY, V41, P129, DOI 10.1159/000112029
  20. Hasler G, 2005, PSYCHIAT RES, V135, P121, DOI 10.1016/j.psychres.2005.03.003
  21. Hollander E, 2007, CNS SPECTRUMS, V12, P5
  22. Jaisoorya TS, 2008, CNS SPECTRUMS, V13, P705
  23. Leckman James F, 2009, Dialogues Clin Neurosci, V11, P21
  24. Koran LM, 1996, AM J PSYCHIAT, V153, P783
  25. LECKMAN JF, 1989, J AM ACAD CHILD PSY, V28, P566, DOI 10.1097/00004583-198907000-00015
  26. Leckman JF, 2008, AM J PSYCHIAT, V165, P1229, DOI 10.1176/appi.ajp.2008.08060891
  27. MCDOUGLE CJ, 1994, ARCH GEN PSYCHIAT, V51, P302
  28. MCDOUGLE CJ, 1993, J CLIN PSYCHOPHARM, V13, P354
  29. Miguel E C, 2001, Adv Neurol, V85, P43
  30. Miguel EC, 2008, REV BRAS PSIQUIATR, V30, P185
  31. Miguel EC, 2009, REV BRAS PSIQUIATR, V31, P85
  32. Miguel EC, 1997, BRIT J PSYCHIAT, V170, P140, DOI 10.1192/bjp.170.2.140
  33. Miguel EC, 2005, MOL PSYCHIATR, V10, P258, DOI 10.1038/sj.mp.4001617
  34. MIGUEL EC, 1995, J CLIN PSYCHIAT, V56, P246
  35. Niederauer KG, 2007, REV BRAS PSIQUIATR, V29, P271, DOI 10.1590/S1516-44462006005000050
  36. Petter T, 1998, J CLIN PSYCHIAT, V59, P456, DOI 10.4088/JCP.v59n0903
  37. Potenza MN, 2009, PSYCHIAT RES, V170, P21
  38. Rosario MC, 2009, CNS SPECTRUMS, V14, P315
  39. Rosario-Campos M C, 2001, Am J Psychiatry, V158, P1899
  40. Rosario-Campos MC, 2006, MOL PSYCHIATR, V11, P495, DOI 10.1038/sj.mp.4001798
  41. Rosario-Campos MC, 2005, AM J MED GENET B, V136B, P92
  42. Torres AR, 2005, REV BRAS PSIQUIATR, V27, P237
  43. Walitza S, 2008, J NEURAL TRANSM, V115, P187, DOI 10.1007/s00702-007-0841-2
  44. WEISSMAN MM, 1994, J CLIN PSYCHIAT, V55, P5

Coleções
Artigos e Materiais de Revistas Científicas - FM/MPS
Artigos e Materiais de Revistas Científicas - HC/IPq
Artigos e Materiais de Revistas Científicas - LIM/21