Plasma cortisol in first episode drug-naive mania: Differential levels in euphoric versus irritable mood
Carregando...
Citações na Scopus
31
Tipo de produção
article
Data de publicação
2012
Título da Revista
ISSN da Revista
Título do Volume
Editora
ELSEVIER SCIENCE BV
Autores
MARQUES, Andrea H.
JURUENA, Mario F.
ANDREAZZA, Ana Cristina
Citação
JOURNAL OF AFFECTIVE DISORDERS, v.138, n.1-2, p.149-152, 2012
Resumo
Background: Dysregulation of HPA axis has been widely described in subjects with bipolar disorder (BD), including changes in cortisol levels during mood episodes and euthymia. However, most of the studies were done with medicated BD patients with variable length of illness, which was shown to interfere on peripheral cortisol levels. Therefore, the present study aims to evaluate plasma cortisol levels in drug-naive BD subjects during the first manic episode, as well as investigate the relationship between plasma cortisol levels and manic symptomatology. Methods: Twenty-six drug-naive patients were enrolled meeting criteria for a first manic episode in bipolar I disorder. Severity of mania was assessed using the Young Mania Rating Scale (YMRS). The control group included 27 healthy subjects matched by age and gender. Cortisol was quantified using a direct radioimmunoassay. Results: Plasma cortisol levels were decreased during first manic episode compared to healthy controls. Higher cortisol levels were positively associated with the presence of irritability (dysphoria), while elated mania showed lower cortisol levels compared to controls. Limitation: Data including larger samples are lacking. Conclusion: Higher cortisol in dysphoric mania compared to predominantly elated/euphoric mania may indicate a clinical and neurobiological polymorphic phenomenon, potentially involving a higher biological sensitivity to stress in the presence of irritable mood. The present findings highlight the importance to add a dimensional approach to the traditional categorical diagnosis for future neurobiological studies in BD.
Palavras-chave
Cortisol, Mania, Depression, Dimensional
Referências
- Bradley AJ, 2010, J PSYCHOPHARMACOL, V24, P91, DOI 10.1177/1359786810385491
- Bschor T, 2003, PHARMACOPSYCHIATRY, V36, pS230
- CARLSON GA, 1973, ARCH GEN PSYCHIAT, V28, P221
- Cassidy F, 1998, J AFFECT DISORDERS, V50, P187, DOI 10.1016/S0165-0327(98)00016-0
- Daban C, 2005, PSYCHIAT CLIN N AM, V28, P469, DOI 10.1016/j.psc.2005.01.005
- Deshauer D, 2003, CAN J PSYCHIAT, V48, P462
- Ellenbogen MA, 2004, PSYCHONEUROENDOCRINO, V29, P99, DOI 10.1016/S0306-4530(02)00135-X
- EROGLU L, 1979, BRIT J CLIN PHARMACO, V8, P89
- EVANS DL, 1983, AM J PSYCHIAT, V140, P615
- GATTAZ WF, 1985, PSYCHONEUROENDOCRINO, V10, P351, DOI 10.1016/0306-4530(85)90012-5
- GODWIN CD, 1984, J AFFECT DISORDERS, V7, P281, DOI 10.1016/0165-0327(84)90049-1
- Goodwin FK, 2007, MANIC DEPRESSIVE ILL
- Hammen C, 2005, ANNU REV CLIN PSYCHO, V1, P293, DOI 10.1146/annurev.clinpsy.1.102803.143938
- HIMMELHOCH JM, 1976, ARCH GEN PSYCHIAT, V33, P1062
- JOYCE PR, 1987, J AFFECT DISORDERS, V12, P1, DOI 10.1016/0165-0327(87)90054-1
- Kessler RC, 1997, ANNU REV PSYCHOL, V48, P191, DOI 10.1146/annurev.psych.48.1.191
- KRISHNAN RR, 1983, AM J PSYCHIAT, V140, P203
- LINKOWSKI P, 1994, ARCH GEN PSYCHIAT, V51, P616
- MCELROY SL, 1992, AM J PSYCHIAT, V149, P1633
- McEwen BS, 2008, EUR J PHARMACOL, V583, P174, DOI [10.1016/j.ejphar.2007.11.071, 10.1016/j.ejphar.2007.11.07t]
- Mello AF, 2007, REV BRAS PSIQUIATR, V29, pS13
- MELTZER HY, 1984, ARCH GEN PSYCHIAT, V41, P379
- PEPIN MC, 1989, MOL BRAIN RES, V6, P77, DOI 10.1016/0169-328X(89)90031-4
- Rush AJ, 1997, BIOL PSYCHIAT, V41, P915, DOI 10.1016/S0006-3223(97)00148-0
- Rybakowski JK, 1999, J PSYCHIAT RES, V33, P363, DOI 10.1016/S0022-3956(99)00014-X
- SCHLESSER MA, 1980, ARCH GEN PSYCHIAT, V37, P737
- Schmider J, 1995, BIOL PSYCHIAT, V38, P797, DOI 10.1016/0006-3223(95)00064-X
- SWANN AC, 1994, BIOL PSYCHIAT, V35, P803, DOI 10.1016/0006-3223(94)91143-6
- SWANN AC, 1992, ACTA PSYCHIAT SCAND, V85, P270, DOI 10.1111/j.1600-0447.1992.tb01468.x
- Vieta E, 1999, PSYCHOL MED, V29, P971, DOI 10.1017/S0033291799008727
- Walker E, 2008, ANNU REV CLIN PSYCHO, V4, P189, DOI 10.1146/annurev.clinpsy.4.022007.141248
- Watson S, 2007, PSYCHONEUROENDOCRINO, V32, P464, DOI 10.1016/j.psyneuen.2007.02.010
- Watson S, 2004, BRIT J PSYCHIAT, V184, P496, DOI 10.1192/bjp.184.6.496
- Yehuda R, 2011, ENDOCRINOLOGY, V152, P4496, DOI 10.1210/en.2011-1218
- Zabel A.W., 2001, J PSYCHIATR RES, V35, P83
- [Anonymous], 2000, DIAGNOSTIC STAT MANU