Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/12291
Title: | Cancer as a Proinflammatory Environment: Metastasis and Cachexia |
Authors: | PINTO, Nelson Inacio; CARNIER, June; OYAMA, Lila M.; OTOCH, Jose Pinhata; ALCANTARA, Paulo Sergio; TOKESHI, Flavio; NASCIMENTO, Claudia M. |
Citation: | MEDIATORS OF INFLAMMATION, article ID 791060, 13p, 2015 |
Abstract: | The development of the syndrome of cancer cachexia and that of metastasis are related with a poor prognostic for cancer patients. They are considered multifactorial processes associated with a proinflammatory environment, to which tumour microenvironment and other tissues from the tumour bearing individuals contribute. The aim of the present review is to address the role of ghrelin, myostatin, leptin, HIF, IL-6, TNF-alpha, and ANGPTL-4 in the regulation of energy balance, tumour development, and tumoural cell invasion. Hypoxia induced factor plays a prominent role in tumour macro-and microenvironment, by modulating the release of proinflammatory cytokines. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MCG Artigos e Materiais de Revistas Científicas - HU Artigos e Materiais de Revistas Científicas - LIM/26 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
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art_PINTO_Cancer_as_a_Proinflammatory_Environment_Metastasis_and_Cachexia_2015.PDF | publishedVersion (English) | 1.79 MB | Adobe PDF | View/Open |
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