Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/1233
Title: | Seizures in Primary Antiphospholipid Syndrome: The Relevance of Smoking to Stroke |
Authors: | CARVALHO, Jozelio Freire de; PASOTO, Sandra Gofinet; APPENZELLER, Simone |
Citation: | CLINICAL & DEVELOPMENTAL IMMUNOLOGY, article ID 981519, 7p, 2012 |
Abstract: | Objectives. To evaluate the frequency of seizures in primary antiphospholipid syndrome (PAPS) and their possible clinical and laboratory associations. Methods. Eighty-eight PAPS patients (Sydney's criteria) were analyzed by a standard interview, physical examination and review of medical charts. Risk factors for seizures, clinical manifestations, associated comorbidities, and antiphospholipid antibodies were evaluated. Results. Nine (10.2%) patients with seizures were identified, 77.8% had convulsions onset after PAPS diagnosis. Mean age, gender, and race were comparable in groups with or without seizures. Interestingly, a higher frequency of current smoking (44.4 versus 10.1%, P = 0.019) was observed in the first group. Stroke, Sneddon's syndrome, and livedo reticularis were more frequent in PAPS patients with seizures than those without seizures, although not statistically significant (P > 0.05). Comparison between patients with seizures onset after PAPS diagnosis (n = 7) and those without convulsions (n = 79) demonstrated a higher frequency of current smoking (42.9 versus 10%, P = 0.042) and stroke in the first group (71.4 versus 30.4%, P = 0.041). Regression analysis confirmed that smoking (P = 0.030) and stroke (P = 0.042) were independently associated to seizures. Conclusion. About 10.2% of PAPS patients had convulsions, predominantly after PAPS diagnosis, and seizures were associated to current smoking and stroke. |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - LIM/17 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_CARVALHO_Seizures_in_Primary_Antiphospholipid_Syndrome_The_Relevance_of_2012.PDF | publishedVersion (English) | 91.54 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.