Please use this identifier to cite or link to this item:
https://observatorio.fm.usp.br/handle/OPI/13434
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor | Sistema FMUSP-HC: Faculdade de Medicina da Universidade de São Paulo (FMUSP) e Hospital das Clínicas da FMUSP | - |
dc.contributor.author | KIM, V. | - |
dc.contributor.author | ABREU, R. M. | - |
dc.contributor.author | NAKAGAWA, D. M. | - |
dc.contributor.author | BALDASSARE, R. M. | - |
dc.contributor.author | CARRILHO, F. J. | - |
dc.contributor.author | ONO, S. K. | - |
dc.date.accessioned | 2016-03-14T14:25:08Z | - |
dc.date.available | 2016-03-14T14:25:08Z | - |
dc.date.issued | 2016 | - |
dc.identifier.citation | JOURNAL OF VIRAL HEPATITIS, v.23, n.3, p.154-169, 2016 | - |
dc.identifier.issn | 1352-0504 | - |
dc.identifier.uri | https://observatorio.fm.usp.br/handle/OPI/13434 | - |
dc.description.abstract | Conventional interferon alfa and nucleos(t)ide analogues, such as lamivudine, are frequently used for chronic hepatitis B (CHB) treatment, but are associated with adverse effects and viral resistance. Here we performed a systematic review and meta-analysis evaluating all studies of pegylated interferon alfa (PEG-IFN) treatment in hepatitis B e antigen (HBeAg)-positive and HBeAg-negative patients with CHB. We searched electronic databases - PubMed, EMBASE, Cochrane Library and LILACS - for randomized controlled trials evaluating PEG-IFN therapy between 1999 and September 2014. Virological response was the primary outcome. We identified 14 studies involving 2829 patients. Our analysis revealed that PEG-IFN+lamivudine combination therapy produced better virological and biochemical responses than PEG-IFN monotherapy in HBeAg-positive and HBeAg-negative patients at the end of treatment. PEG-IFN+adefovir dipivoxil achieved better seroconversion rate than PEG-IFN in HBeAg-positive patients at the end of treatment. The present findings demonstrated a beneficial response rate following PEG-IFN combination therapy with nucelos(t)ides among HBeAg-positive and HBeAg-negative patients with CHB. Further trials are needed to investigate simultaneous and sequential therapy strategies. | - |
dc.description.sponsorship | Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [576631/2008-6] | - |
dc.description.sponsorship | Alves de Queiroz Family Fund for Research | - |
dc.language.iso | eng | - |
dc.publisher | WILEY-BLACKWELL | - |
dc.relation.ispartof | Journal of Viral Hepatitis | - |
dc.rights | restrictedAccess | - |
dc.subject | chronic hepatitis B | - |
dc.subject | meta-analysis | - |
dc.subject | pegylated interferon alfa | - |
dc.subject | randomized controlled trials | - |
dc.subject.other | lamivudine combination therapy | - |
dc.subject.other | randomized controlled-trial | - |
dc.subject.other | hbeag-negative patients | - |
dc.subject.other | peginterferon alpha-2a | - |
dc.subject.other | adefovir dipivoxil | - |
dc.subject.other | acute exacerbation | - |
dc.subject.other | disease burden | - |
dc.subject.other | monotherapy | - |
dc.subject.other | efficacy | - |
dc.subject.other | hbsag | - |
dc.title | Pegylated interferon alfa for chronic hepatitis B: systematic review and meta-analysis | - |
dc.type | article | - |
dc.rights.holder | Copyright WILEY-BLACKWELL | - |
dc.identifier.doi | 10.1111/jvh.12418 | - |
dc.identifier.pmid | 25967226 | - |
dc.subject.wos | Gastroenterology & Hepatology | - |
dc.subject.wos | Infectious Diseases | - |
dc.subject.wos | Virology | - |
dc.type.category | review | - |
dc.type.version | publishedVersion | - |
hcfmusp.description.beginpage | 154 | - |
hcfmusp.description.endpage | 169 | - |
hcfmusp.description.issue | 3 | - |
hcfmusp.description.volume | 23 | - |
hcfmusp.origem | WOS | - |
hcfmusp.origem.id | 2-s2.0-84957432364 | - |
hcfmusp.origem.id | WOS:000369161000001 | - |
hcfmusp.publisher.city | HOBOKEN | - |
hcfmusp.publisher.country | USA | - |
hcfmusp.relation.reference | Rijckborst V, 2011, ALIMENT PHARM THER, V33, P501, DOI 10.1111/j.1365-2036.2010.04555.x | - |
hcfmusp.relation.reference | Higgins JPT, 2011, BMJ-BRIT MED J, V343, DOI 10.1136/bmj.d5928 | - |
hcfmusp.relation.reference | Higgins JPT, 2002, STAT MED, V21, P1539, DOI 10.1002/sim.1186 | - |
hcfmusp.relation.reference | Huang Z, 2013, J VIRAL HEPATITIS, V20, P52, DOI 10.1111/jvh.12064 | - |
hcfmusp.relation.reference | LIAW YF, 1994, J HEPATOL, V20, P175, DOI 10.1016/S0168-8278(05)80055-8 | - |
hcfmusp.relation.reference | Werle-Lapostolle B, 2004, GASTROENTEROLOGY, V126, P1750, DOI 10.1053/j.gastro.2004.03.018 | - |
hcfmusp.relation.reference | Manesis EK, 2007, ANTIVIR THER, V12, P73 | - |
hcfmusp.relation.reference | LOK ASF, 1992, GASTROENTEROLOGY, V102, P2091 | - |
hcfmusp.relation.reference | Zhao H, 2007, CLIN INFECT DIS, V44, P541, DOI 10.1086/511042 | - |
hcfmusp.relation.reference | Liu YH, 2014, J HUAZHONG U SCI-MED, V34, P542, DOI 10.1007/s11596-014-1312-2 | - |
hcfmusp.relation.reference | Chen CC, 2012, J VIRAL HEPATITIS, V19, P161, DOI 10.1111/j.1365-2893.2011.01469.x | - |
hcfmusp.relation.reference | Ning Q, 2014, J HEPATOL, V61, P777, DOI 10.1016/j.jhep.2014.05.044 | - |
hcfmusp.relation.reference | Kaymakoglu S, 2007, ANTIMICROB AGENTS CH, V51, P3020, DOI 10.1128/AAC.00088-07 | - |
hcfmusp.relation.reference | Moucari R, 2011, J VIRAL HEPATITIS, V18, P580, DOI 10.1111/j.1365-2893.2010.01332.x | - |
hcfmusp.relation.reference | Liaw YF, 1999, HEPATOLOGY, V30, P567, DOI 10.1002/hep.510300221 | - |
hcfmusp.relation.reference | Fung SK, 2004, J VIRAL HEPATITIS, V11, P432, DOI 10.1111/j.1365-2893.2004.00556.x | - |
hcfmusp.relation.reference | Hadziyannis SJ, 2005, NEW ENGL J MED, V352, P2673, DOI 10.1056/NEJMoa042957 | - |
hcfmusp.relation.reference | Cooksley WGE, 2003, J VIRAL HEPATITIS, V10, P298, DOI 10.1046/j.1365-2893.2003.00450.x | - |
hcfmusp.relation.reference | Lai CL, 1998, NEW ENGL J MED, V339, P61, DOI 10.1056/NEJM199807093390201 | - |
hcfmusp.relation.reference | Shi Y, 2010, HEPATOB PANCREAT DIS, V9, P462 | - |
hcfmusp.relation.reference | Janssen HLA, 2005, LANCET, V365, P123, DOI 10.1016/S0140-6736(05)17701-0 | - |
hcfmusp.relation.reference | Hadziyannis SJ, 2012, GASTROENTEROLOGY, V143, P629, DOI 10.1053/j.gastro.2012.05.039 | - |
hcfmusp.relation.reference | Wang YD, 2012, HEPATO-GASTROENTEROL, V59, P680, DOI 10.5754/hge12183 | - |
hcfmusp.relation.reference | Moucari R, 2009, HEPATOLOGY, V49, P1151, DOI 10.1002/hep.22744 | - |
hcfmusp.relation.reference | Feld J, 2003, HEPATOLOGY, V38, P545, DOI 10.1053/jhep.2003.50389 | - |
hcfmusp.relation.reference | Xie Q, 2014, CLIN INFECT DIS, V59, P1714, DOI 10.1093/cid/ciu702 | - |
hcfmusp.relation.reference | Levrero M, 2009, J HEPATOL, V51, P581, DOI 10.1016/j.jhep.2009.05.022 | - |
hcfmusp.relation.reference | Boglione L, 2013, J VIRAL HEPATITIS, V20, pe11, DOI 10.1111/jvh.12018 | - |
hcfmusp.relation.reference | Lampertico P, 2003, HEPATOLOGY, V37, P756, DOI 10.1053/jhep.2003.50148 | - |
hcfmusp.relation.reference | Lavanchy D, 2004, J VIRAL HEPATITIS, V11, P97, DOI 10.1046/j.1365-2893.2003.00487.x | - |
hcfmusp.relation.reference | Lampertico P, 2013, GUT, V62, P290, DOI 10.1136/gutjnl-2011-301430 | - |
hcfmusp.relation.reference | Cao ZH, 2013, J DIGEST DIS, V14, P446, DOI 10.1111/1751-2980.12065 | - |
hcfmusp.relation.reference | Goldstein ST, 2005, INT J EPIDEMIOL, V34, P1329, DOI 10.1093/ije/dyi206 | - |
hcfmusp.relation.reference | Lai CL, 2003, CLIN INFECT DIS, V36, P687, DOI 10.1086/368083 | - |
hcfmusp.relation.reference | Piccolo P, 2009, ANTIVIR THER, V14, P1165, DOI 10.3851/IMP1466 | - |
hcfmusp.relation.reference | Papadopoulos VP, 2009, MED SCI MONITOR, V15, pCR56 | - |
hcfmusp.relation.reference | Hadziyannis SJ, 2000, HEPATOLOGY, V32, P847, DOI 10.1053/jhep.2000.17915 | - |
hcfmusp.relation.reference | Lau GKK, 2005, NEW ENGL J MED, V352, P2682, DOI 10.1056/NEJMoa043470 | - |
hcfmusp.relation.reference | [Anonymous], 2009, J HEPATOL, V50, P227 | - |
hcfmusp.relation.reference | Huang ZL, 2013, EUR J GASTROEN HEPAT, V25, P1165, DOI 10.1097/MEG.0b013e3283612e95 | - |
hcfmusp.relation.reference | Liaw YF, 2013, HEPATOLOGY, V58, P1856, DOI 10.1002/hep.26358 | - |
hcfmusp.relation.reference | Marcellin P, 2004, NEW ENGL J MED, V351, P1206, DOI 10.1056/NEJMoa040431 | - |
hcfmusp.relation.reference | Deng Zhenzhen, 2013, Zhong Nan Da Xue Xue Bao Yi Xue Ban, V38, P1193, DOI 10.3969/j.issn.1672-7347.2013.12.001 | - |
hcfmusp.relation.reference | European Asscociation For The Study Of The Liver, 2012, J HEPATOL, V57, P167, DOI 10.1016/J.JHEP.2012.02.010] | - |
hcfmusp.relation.reference | Higgins JP, 2011, COCHRANE COLLABORATI, DOI 10.1136/BMJ.D5928 | - |
hcfmusp.relation.reference | Kioko Ono-Nita S, 2001, CURR INFECT DIS REP, V3, P137, DOI 10.1007/s11908-996-0036-2 | - |
hcfmusp.relation.reference | Lacey L, 2004, J GASTROEN HEPATOL, V19, pS10, DOI 10.1111/j.1440-1746.2003.03392.x | - |
hcfmusp.relation.reference | Marcellin P, 2014, HEPATOLOGY S, V60, p294A | - |
hcfmusp.relation.reference | Piccolo P, 2013, ANTIVIR THER, V18, P57, DOI 10.3851/IMP2281 | - |
hcfmusp.relation.reference | Suh DJ, 2014, ANTIVIR THER, V18, P765 | - |
hcfmusp.relation.reference | World Health Organization, 2014, HEP B | - |
dc.description.index | MEDLINE | - |
dc.identifier.eissn | 1365-2893 | - |
hcfmusp.citation.scopus | 31 | - |
hcfmusp.scopus.lastupdate | 2024-04-12 | - |
Appears in Collections: | Artigos e Materiais de Revistas Científicas - FM/MGT Artigos e Materiais de Revistas Científicas - HC/ICHC Artigos e Materiais de Revistas Científicas - HC/InRad Artigos e Materiais de Revistas Científicas - LIM/07 Artigos e Materiais de Revistas Científicas - ODS/03 |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
art_KIM_Pegylated_interferon_alfa_for_chronic_hepatitis_B_systematic_2016.PDF Restricted Access | publishedVersion (English) | 1.31 MB | Adobe PDF | View/Open Request a copy |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.